Novel approaches to generate alkylpyrazine derivatives Vom Fachbereich Chemie der Universität Hannover zur Erlangung des Grades Doktor der Naturwissenschaften -Dr. rer. nat.- genehmigte Dissertation von Dipl.-Biologen Toshinari Kurniadi geboren am 28. Mai 1977 in München 2003 Novel approaches to generate alkylpyrazine derivatives Page 2 Referent: Prof. Dr.rer.nat. Dr.Ing.-habil. R. G. Berger Koreferenten: Dr. M.-A. Juillerat Prof. Dr. H. Meyer Tag der Promotion: 18. Dezember 2002 Novel approaches to generate alkylpyrazine derivatives Page 3 The present work was carried out in the Nestlé Research Centre (Lausanne) from January 2000 to August 2002 under the supervision of Dr. Marcel-Alexandre Juillerat (Nestlé) and Prof. Ralf Günter Berger (Universität Hannover). Acknowledgements I would like to appreciate Dr. Marcel-Alexandre Juillerat for his excellent and professional supervision of the Ph.D. thesis. His great managing skills combined with his brilliant base of scientific understanding have been crucial for the progress and successful outcome of this work. Furthermore, he has sent me to various courses, in which I could significantly improve my language, communication, and presentation skills. Prof. Ralf Günter Berger for having accepted me as one of his external Ph.D. students.