Fifth international symposium on bovine leukosis

Fifth international symposium on bovine leukosis

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Commission of the European Communities
AGRICULTURE
Fifth international symposium
on bovine leukosis
Report
EUR 8471 EN Commission of the European Communities
AGRICULTURE
Fifth international symposium
on bovine leukosis
A symposium in the CEC Programme of Coordination
of Research on Animal Pathology,
held at Tübingen, Federal Republic of Germany,
19-21 October 1982
Edited by
O. C. Straub
Bundesforschungsanstalt für Viruskrankheiten der Tiere
Postfach 1149
D-7400 Tübingen
Sponsored by the
Commission of the European Communities
Directorate-General for Agriculture
Coordination of Agricultural Research ítf$Jiàkiafâtfr
1984 EUR 8471 EN Published by the
COMMISSION OF THE EUROPEAN COMMUNITIES
Directorate­General
Information Market and Innovation
Bâtiment Jean Monnet
LUXEMBOURG
LEGAL NOTICE
Neither the Commission of the European Communities nor any person acting on
behalf of the n is responsible for the use which might be made of the
following information
Cataloguing data can be found at the end of this publication
Luxembourg, Office for Official Publications of the European Communities, 1984
ISBN 92­825­4559­8
Catalogue number:^ Wk
© ECSC­EEC­EAEC,Brussels ■ Luxembourg, 1984
Printed in the FR of Germany PREFACE
The CEC common research programme on enzootic bovine
leukosis (EBL) was terminated last year. During the eight-
year period a number of workshops and symposia were sponsored
by the CEC. This volume contains the proceedings of the last
the "Fifth International Symposium on Enzootic Bovine
Leukosis" held at Tübingen (1982), where the first workshop
(1974) marked the beginning of the research programme.
Included are also the papers of the last workshop held at the
Moredun Institute, Edinburgh, 13-15 September 1983, a
leftover from the fourth symposium (Bologna, 1980) and the
"Evaluation of the CEC Common Research Programme on Enzootic
Bovine Leukosis (EBL)" by Professor Y.BECKER, Scientific adviser,
Hebrew University of Jerusalem conceived after the workshop held in
Dublin (1981).
At this point I wish to express the appreciation of the
participants to Professor Becker for his engagement and
advice offered during those years.
Eight years of EBL research have greatly widened our
knowledge on this slow disease in the fields of basic and
applied science. Without the support of the CEC this progress
would not have been achieved during such a relatively short
period of time. Not only EC countries will benefit from this
research programme but all those which have a cattle
population infected with bovine leukosis virus.
Although funds became rather limited during the later
years it was still possible to invite scientists from non-EC
countries to participate at the symposia and have their
papers included in the proceedings. Some blemishes will be noticeable during the study of
the proceedings. Those are partly due to different spelling
by the authors. I am specially indebted to Mrs. Helen C.
Jackson for help in improving the English of papers written
by scientists whose mother tongue is not English (American),
to Mrs. Marie-Luise Donner, Mrs. Christel Roming and Mrs.
Claudia Dicker for their efforts in typing the manuscripts
and to Mr. Peter Schröter for the improvement of a number of
figures. I am especially grateful for the skilful technical
assistance provided through many years by Mrs. Gabriele
Kuebart and Mrs. Barbara Zoeth.
Last but no least I would like to thank Mr. J. Connell,
CEC Brussels, for his tremendous interest in the subject and
his personal engagement in this matter.
Although the EBL programme has been concluded I am sure
that contacts beyond borders will continue whereeyer EBL
research is still conducted. A number of problems have been
solved, many questions, however, remain still open.
Tübingen, May 1984
Otto Christian Straub
IV CONTENTS
Page
Preface III
SESSION I: The Bovine Leukosis Virus 1
BOVINE LEUKOSIS VIRUS - A MOLECULAR VIROLOGIST'S
REVIEW
Y. Becker 3
BOVINE LEUKEMIA PROVIRUS IS NOT INTEGRATED IN A NARROW
DOMAIN OF THE HOST DNA
R. Kettmann, D. Couez, F. Crespeau, J. Deschamps, M.
Mammerickx, C. Olson, M. Onuma, A.-L. Parodi, M.J.
Van der Maaten and A. Burny 18
RELATIVE IMPORTANCE OF DIFFERENT BOVINE LEUKEMIA VIRUS
ENVELOPE GLYCOPROTEIN (GP51) ANTIGENIC SITES IN THE
HOST-VIRUS INTERACTIONS - A STUDY WITH MONOCLONAL
ANTIBODIES
C. Brück, D. Porteteile, A. Burny and J. Zavada 29
INTEGRATION SITES OF BLV PROVIRUS IN THE TUMOR
CELL GENOME: IMPLICATIONS FOR THE
MECHANISM OF LEUKEMOGENESIS
D. Grégoire, R. Kettmann, D. Couez, G. Huez,
D. Porteteile and A. Burny 39
USE OF MONOCLONAL ANTIBODIES IN THE
STUDY OF BLV GLYCOPROTEIN GP51.
CONSEQUENCES FOR A VACCINE
D. Portetene, C. Brück, J. Ghysdael,
M. Mammerickx and A. Burny 4 5 EFFECT OF TUNICAMYCIN ON CELL FUSION INDUCED BY
BOVINE LEUKEMIA VIRUS PRODUCING CELLS
M. Onuma, R. Moriguchi, T. Mikami, H. Izawa 52
BOVINE LEUKAEMIA VIRUS EXPRESSION IN
CULTURED CELLS
R.Z. Mamoun, T. Astier, R. Kettmann,
Β. Guillemain 65
CHARACTERISTICS OF A HUMAN T­CELL LEUKEMIA
VIRUSISOLATED FROM PATIENTS WITH
T­CELLMALIGNANCIES
P.S.Sarinand R.C. Gallo89
PRELIMINARY STRUCTURAL ANALYSIS OF
BLV­PLASMID RECOMBINANTS
S. Rosenthal, D.H. Liebscher, R. Kettmann,
Chr. Pöhlmann, G. Nyakatura, U. Nötzel,
Β. Drescher, J. Winkler, V. Hahn and A. Burny 103
SPECIFICITY AND MECHANISMS OF EARLY AND LATE
POLYKARYOCYTOSIS INDUCED BY DIFFERENT ISOLATES
OF THE BOVINE LEUKEMIA VIRUS
B. Guillemain, R. Mamoun, T. Astier, J.F. Duplan II7
THE EFFECT OF BIOLOGICALLY ACTIVE COMPOUNDS ON
THE GROWTH OF BOVINE LEUKEMIA VIRUS
IN FETAL LAMB KIDNEY CELLS
D. Scholz, H. Rössler, Η. Bossmann,
H.A. Rosenthal and S. Rosenthal 1*0
SESSION II: IMMUNOLOGY AND BIOCHEMISTRY I47
IMMUNOLOGICAL MECHANISMS OF THE VIRUS­INDUCED
LEUKEMIAS
D. Levy 1*9 ENZOOTIC BOVINE LEUKOSIS: BIOCHEMICAL ASPECTS
A. Burny, C. Brück, D. Couez, J. Deschamps,
J. Ghysdael, R. Kettmann, G. Marbaix, D. Portetene.. τ 61
DETECTION OF CELL SURFACE ANTIGEN ON TRANSFORMED
CELLS USING MONOCLONAL ANTIBODIES
M. Onuma, K. Hamada, Y. Ogawa, Y. Aida,
165 T. Mikami and H. Izawa
IMMUNOLOGICAL AND CYTOGENETICAL STUDIES ON
LYMPHOCYTES FROM NORMAL AND LYMPHOCYTOTIC CATTLE
G. Poli, L. Bonizzi, L. Oldani, C. Caldora,
G. Redaelli, G. Vacirca, G. Gentile 176
HOST IMMUNE RESPONSES IN NUDEMICETRANSPLANTED
WITH BOVINE LEUKEMIA CELL LINE(FLK)
H. Kodarna, M. Onuma, K. Matsumoto,S.Yamamoto,
M. Naiki, T. Mikami, H. Izawa 186
IMMUNOCHEMICAL CHARACTERIZATION OF MAJOR
HISTOCOMPATIBILITYANTIGENSINBOVINE CATTLE
D. Levy, M. Hoang-Xuan,H.Leveziel,
M.T. Zilber, A.L. Parodi199
IMMUNOSUPPRESSIVE PROPERTIES OF SERA FROM ANIMALS
INFECTED WITH BOVINE LEUKOSIS VIRUS
J. Grundboeck-Jusko, M. Grundboeck, J. Stec 207
BOVINE LEUKOSIS: LACK OF EVIDENCE FOR GENERALIZED
IMMUNOSUPPRESSION IN CATTLE WITH CLINICAL LEUKOSIS
(LYMPHOSARCOMA)
R.D. Schultz, J.R. Duncan 213
MECHANISMS OF PREVENTIONOFBOVINE LEUKOSIS
BY IMMUNE RESPONSES
M. Onuma, S. Yamamoto,K.Hamada, Y. Ogawa,
H. Kodarna, T. MikamiandH.Izawa221SESSION III: TRANSMISSION AND PATHOGENESIS 231
INTRODUCTORY REMARKS ON NATURAL AND EXPERIMENTAL
TRANSMISSIONS OF ENZOOTIC BOVINE LEUKOSIS
M. Mammerickx, C. Brück, A. Burny, R. Kettmann,
D. Porteteile, J. Leunen 233
STUDY OF BOVINE LEUKEMIA VIRUS TRANSMISSION
FOLLOWING TRANSFER OF EMBRYOS FROM
INFECTED TO UNINFECTED CATTLE
A.-L. Parodi, G. Manet, A. Vuillaume,
F. Crespeau, B. Toma and D. Levy 246
A RELATIONSHIP BETWEEN BOVINE LEUKOSIS AND
BLV INFECTION. MODES OF TRANSMISSION,
PREVENTION AND CONTROL MEASURES
G.A. Simonyan, V.P. Shishkov, E.F. Brazhin 253
THE IMPORTANCE OF THE SEROPOSITIVE DAM'S
STATE FOR THE TRANSMISSION AND SPREAD
OF ENZOOTIC BOVINE LEUKOSIS
O.C. Straub 258
LYMPHOCYTE DETECTION IN BULL SEMEN BY FLOW
CYTOMETRY AS A COMPLEMENTARY TEST IN
THE CONTROL OF BLV TRANSMISSION
G. Bottiroli, G. Poli, G. Mazzini, G. Vacirca,
G. Aureli, V. Marazza, E. Moraschina,
G. Gentile 265
VIROLOGICAL EXAMINATION OF MILK, SEMEN AND BLOOD
FROM CATTLE INFECTED WITH BOVINE LEUKOSIS VIRUS
A.F. Valikhov, L.G. Burba, V.P. Shishkov 269
THE ROLE OF COLOSTRUM AND MILK IN TRANSMISSION OF
ENZOOTIC BOVINE LEUKOSIS
O.C. Straub 272