Tutorial on Modern Methods for Genetic Association Studies and Fine Mapping of Disease Genes

Petra Rössler

Informations

• Publié par: Vofeg
• Nombre de lectures: 14
• Langue: English

Extrait

50. Jahrestagung der Deutschen Gesellschaft für Medizinische

Informatik, Biometrie und Epidemiologie (gmds)

11. - 15. September 2005

12. Jahrestagung der Deutschen Arbeitsgemeinschaft für

Epidemiologie (dae)

14. - 15. September 2005

Freiburg im Breisgau

Satellite Tutorial

Modern Methods for Genetic Association Studies

and Fine Mapping of Disease Genes

Professor

Duncan C. Thomas

, University of Southern California

Heidelberg, September 16, 2005

Contents of Course

Classical gene discovery is based on linkage analysis (within families), followed by association studies

(across families).

These basic design and analysis principles have been well established for over a decade,

albeit with continual evolution in such areas as multipoint linkage and association analysis, family-based

association studies, and genomic control for population stratification.

In this tutorial, I will review these basics

in the first session, and then focus on some more recent developments.

The discovery of haplotype block structure in the human genome has lent momentum to the use of haplotype

associations and designs based on selection of a subset of haplotype-tagging SNPs for association studies,

particularly for uncovering indirect signals with variants that may not yet have been discovered.

The second

session will focus on methods for testing and characterizing candidate gene associations, and using densely

spaces markers for fine mapping, including haplotype association and haplotype sharing methods and gene-

environment or gene-gene interactions.

The field of molecular epidemiology is also rapidly moving from the stage of considering single genes one-at-

a-time (or in pair wise combinations with each other or with a single environmental factor) towards

consideration of entire pathways involving many genes and environmental factors in combination.

Study

designs and analysis methods for attacking such pathway-driven research are still in their infancy, however.

Finally, recent genotyping technology advances have now made it possible to consider genome-wide

association scans involving, say, 600,000 SNPs on large case-control samples.

Again, cost-efficient study

designs and analysis methods that would extract the maximum possible information out of such studies are

an active area of research.

These two topics will be addressed in the third session.

Course lecturer

Duncan C Thomas is Professor and Director of the Biostatistics Division, Verna Richter Chair in Cancer

Research, Department of Preventive Medicine, the University of Southern California Keck School of Medicine

His research interests include the development of statistical methods in epidemiology, with special emphasis

on cancer epidemiology and occupational and environmental health. He is also developing statistical

methods for genetic epidemiology, especially for studies of the relationship of gene-environment interactions

to diabetes, breast cancer, and other cancers. He recently wrote a book on 'Statistical Methods in Genetic

Epidemiology’ published 2004 by the Oxford University Press.

Registration:

Friday, September 16, 2005 at 8:00 a.m.

Time Course:

8:30 a.m. – 3:00 p.m.

Under the patronage of the

German Epidemiological Association (DAE)

German Research Foundation (DFG)

Financially supported by:

DFG (Graduiertenkolleg 793)

Organized by:

Prof. Dr. Jenny Chang-Claude

Deutsches Krebsforschungszentrum

Abteilung Klinische Epidemiologie

Im Neuenheimer Feld 280

D- 69120 Heidelberg

e-mail:

[e-mail]

Administrative staff and contact address:

Elke Braun-van der Hoeven

Universität Heidelberg

Sekretariat, Graduiertenkolleg 793

Im Neuenheimer Feld 324

D- 69120 Heidelberg

e-mail: [e-mail]

Application Deadline:

July 31, 2005

Number of participants:

max. 35

Course language

:

English

Course Fees

:

60€

regular fee

50€

DAE members

30€

Students (certificate needed)

The course fee includes course material and refreshments during the course.

Ceritificate of Attendance

:

Each participant will receive a certificate of attendance.

Venue

:

Deutsches Krebsforschungszentrum Heidelberg (DKFZ),

Großer Seminarraum der ATV

Im Neuenheimer Feld 242, 69120 Heidelberg

Sitemap:

http://www.dkfz.de/de/dkfz/anfahrt.html

Registration Form

Tutorial: “

Modern Methods for Genetic Association Studies and Fine Mapping of Disease Genes

”

by Professor Duncan C. Thomas, University of Southern California

Heidelberg, September 16, 2005

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Elke Braun-van der Hoeven

Universität Heidelberg

Sekretariat, Graduiertenkolleg 793

Im Neuenheimer Feld 324

D- 69120 Heidelberg

e-mail: [e-mail]

fax:

+49-[phone]

Banking account:

Account Nr.: 5302780100

Bank:

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BLZ:

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