Spatial remapping mechanisms and their impairments in patients with right parietal lesions [Elektronische Ressource] / vorgelegt von Leandra Bucher

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Informations

• Publié par: ludwig-maximilians-universitat_munchen
• Publié le: 01 janvier 2008
• Nombre de lectures: 17
• Langue: English
• Poids de l'ouvrage: 3 Mo

Extrait

SPATIAL REMAPPING MECHANISMS
AND THEIR IMPAIRMENTS IN
PATIENTS WITH RIGHT PARIETAL LESIONS


Inaugural-Dissertation zur Erlangung des
Doktorgrades der Philosophie an der
Ludwig-Maximilians-Universität
München


vorgelegt von
Leandra Bucher
aus
München


Oktober 2008
Prüfer:

Prof. Dr. Hermann Müller, Department für Psychologie, LMU
Prof. Dr. Kathrin Finke, Department für Psychologie, LMU
PD Dr. Cornelis Stadtland, Department für Medizin, LMU


Tag der mündlichen Prüfung: 10. Dezember 2008

Acknowledgements


I would like to thank Hermann J. Müller for providing valuable support, and for
numerous inspiring research meetings in and also outside of Munich. I am exceptionally
grateful to Kathrin Finke who accompanied and supervised me throughout all the stages of
my work, always considerably helpful and patient, always offering ideas and solutions.
Additionally, I am grateful to Peter Bublak who contributed a lot of expertise, and greatly
helped with data preparation. I am greatly indebted to Georg Kerkhoff for introducing me at
first to the very interesting field of neuropsychological research, and for his support and help
throughout the years. I am thankful to Thomas Geyer for programming and introducing me to
the experiments, for help in case of questions, and for discussions. I thank my colleagues at
the department for sharing an interesting time, enriched by discussions, lots of coffee, and
fun. I wish to express my gratitude to Ingo Keller for all his support and for the great
opportunity to collect data in the neurological clinic Bad Aibling. Exquisite thanks go to
Gudrun Lefin for her priceless help with organisation and recruitment of patients. I thank my
colleagues in Bad Aibling for contributing to the warm and friendly atmosphere in the clinic
and for their help and kindness in the recent years. I am deeply grateful to Friedrich v. Rosen
for judging lesion data in innumerable meetings and sharing his knowledge about brain
structures with me. I would like to thank all my subjects. Notably, I am grateful to “my”
patients who – despite facing hard situations – participated persistently and patiently in
numerous experimental sessions. Special thanks go to Ellen (“Dr. Nase”) and Melissa, and to
all my friends for unshakable faith and support in so many ways. Very special thanks go to
my parents, Marianne and Toni, to my brothers, Martin and Matthias, and to my boyfriend,
Matthew, for incredible patience, endless support, and for so much more.
Munich, October 2008


Table of contents


Acknowledgements…………………………………………………………………..... 1
Table of contents……………………………………………………………………..... 2

I. CHAPTER: SYNOPSIS………………………………………………………….... 6
1. General introduction……………………………………………………….. 7
1. 1 Concepts to explain the achievement of visual stability.......................... 8
1. 1. 1 “Neural inflow hypothesis”........................................................ 8
1. 1. 2 “Neural outflow hypothesis”...................................................... 9
1. 2 Classical approaches...................................................................................... 10
1. 2. 1 The idea of elimination................................................................ 10
1. 2. 2 The idea of translation................................................................. 10
1. 2. 3 The idea of evaluation.................................................................. 11
1. 2. 4 The idea of calibra11
2. A theoretical framework of spatial remapping............................................ 12
2. 1 Saliency map............................................................................................ 12
2. 2 Two stages of visual processing.............................................................. 13
2. 3 Spatial remapping....13
2. 4 The neuroanatomy of spatial remapping................................................. 14
2. 5 Spatial remapping deficits after parietal lesions...................................... 14
2. 6 Contribution of spatial remapping deficits to visual search impairments
in neglect................................................................................................. 16
2. 7 Spatial remapping abilities and limitations in healthy persons................. 17
2. 8 The role of overt and covert attention...................................................... 17
Table of contents 3

3. Priming of pop-out as a method to investigate spatial remapping............. 18
4. Introduction to the current studies............................................................... 19

II. CHAPTER: STUDY 1
LOCATION PRIMING OUTLIVES OVERT AND COVERT SHIFTS OF ATTENTION IN
HEALTHY SUBJECTS............................................................................................. 22
1. Abstract........................................................................................................... 23
2. Introduction..................................................................................................... 24
3. Control Experiment (1).................................................................................. 28
3. 1 Method..................................................................................................... 28
3. 2 Results and Discussion............................................................................ 30
4. Retinotopic Experiment (2)........................................................................... 34
4. 1 Method..................................................................................................... 33
4. 2 Results and Discussion............................................................................ 34
5. Spatiotopic Experiment (3)............................................................................ 37
5. 1 Method..................................................................................................... 37
5. 2 Results and Discussion............................................................................ 38
6. Long-ISI-Control Experiment (4)................................................................. 41
6. 1 Method..................................................................................................... 41
6. 2 Results and Discussion............................................................................ 41
7. Irrelevant Distractor Experiment (5)............................................................ 44
7. 1 Method..................................................................................................... 44
7. 2 Results and Discussion............................................................................ 45
8. Relevant Distractor Experiment (6).............................................................. 48
8. 1 Method..................................................................................................... 48
Table of contents 4

8. 2 Results and Discussion............................................................................ 48
9. Conclusion....................................................................................................... 52

III. CHAPTER: STUDY 2
ARE THERE SACCADIC SPATIAL REMAPPING DEFICITS IN PATIENTS WITH RIGHT
PARIETAL LESIONS?…………….………………................................................ 55
1. Abstract........................................................................................................... 56
2. Introduction.................................................................................................... 57
3. Control Experiment (7).................................................................................. 65
3. 1 Method..................................................................................................... 65
3. 2 Results...................................................................................................... 69
3. 3 Discussion................................................................................................ 75
4. Saccade experiment (8).................................................................................. 78
4. 1 Method..................................................................................................... 78
4. 2 Results...................................................................................................... 81
4. 3 Discussion................................................................................................ 85
5. Spatial remapping experiment (9)................................................................ 87
5. 1 Method..................................................................................................... 87
5. 2 Results..................................................................................................... 89
5. 3 Discussion................................................................................................ 94
6. Conclusion....................................................................................................... 95

IV. CHAPTER: STUDY 3
DO