Technological separation and analysis of flavanones from different plants and their microbiological activity [Elektronische Ressource] / Iwona Małgorzata Proczek. Gutachter: Harun Parlar ; Andrzej K. Bledzki. Betreuer: Harun Parlar

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• Publié par: technische_universitat_munchen
• Publié le: 01 janvier 2011
• Nombre de lectures: 58
• Langue: English
• Poids de l'ouvrage: 5 Mo

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Technische Universität München

Lehrstuhl für
Chemisch-Technische Analyse und Chemische Lebensmitteltechnologie


Technological separation and analysis of flavanones
from different plants and their microbiological activity


Iwona Małgorzata Proczek



Vollständiger Abdruck der von der Fakultät Wissenschaftszentrum Weihenstephan für
Ernährung, Landnutzung und Umwelt der Technischen Universität München zur Erlangung
des akademischen Grades eines
Doktor-Ingenieurs
genehmigten Dissertation.


Vorsitzender: Univ.-Prof. Dr. K.-H. Engel
Prüfer der Dissertation:
1. Univ.-Prof. Dr. Dr. h.c. H. Parlar
2. Univ.-Prof. Dr. Dr. h.c. A. K. Bledzki
(Universität Kassel)



Die Dissertation wurde am 26.01.2011 bei der Technischen Universität München
eingereicht und durch die Fakultät Wissenschaftszentrum Weihenstephan für Ernährung,
Landnutzung und Umwelt am 20.06.2011 angenommen. First and foremost, I would like to express my gratitude to Prof. Dr. Dr. Harun Parlar,
not only for the interesting subject material and making my dissertation possible, but also for
his professional guidance, helpful advice, financial assistance and continuous support during
all aspects of this thesis.
I wish to express my sincere appreciation to Prof. Dr. Karl-Heinz Engel from the
Department of General Food Technology kindly accepting the position as chairman in my
examination, and to Prof. Dr. Andrzej Bledzki, from the University in Kassel, for being my
second thesis reviewer.
I am also grateful to Dr. Frank Otto for answering many of my questions on various
applications, for the fruitful discussions, for his encouragement, patience, a big aid and
supervision all throughout the thesis also from a distance. You should know that without your
help it would be very difficult for me to write this thesis.
I want to emphasize a special thanks to Albrecht Friess for the incredible atmosphere
during these 3 years, and especially for proofreading my thesis. Thank you for providing me
with a lot of helpful, advice and for the continuous willingness to help.
I would like to express my thanks to Dr. Vogel, and especially his successor
Dr. Mathias Hutzler from the Institute for Brewing and Food Quality, for kindly lending me
a laboratory, for the active collaboration, and the patient understanding.
My special thanks also go to Margit Gramma from the Institute for Brewing and Food
Quality for helping me with the analyses, her smile which always brought a nice atmosphere,
and her continuous readiness to help.
I also owe many thanks to Dr. Ludwig M. Niessen from the Department of Technical
Microbiology for allowing me to use the SunRise Tecan and also Patrick Preissler for his
kindly help by analyses.
I am also indebted to Dr. Martin Haslbeck, from the Department of Biotechnology in
Garching, for making the circular dichroism analyses possible, and for all the help and advice.
I would like to thank Dr Thomas Letzel for allowing me to use the mass spectrometer,
and Silvia Grosse for her support during the analyses and the pleasant atmosphere at the
office. I want to emphasize a special thanks to Dr. Mehmed Colhan for his help and kind
words in difficult moments.
Many thanks also to Daniela Schossig and Julia Meineke, from the RAPS Forschung
Zentrum, for wonderful cooperation. Thanks to Dr. Johanna Graβmann, Romy Scheerle
and Dr. Florian Weiland for sharing the office and nice environment.
I also owe many thanks to Jutta Pierschalik, Claudia Steinmetz and Irene Goros for
providing me with the various documents, gracious aid and wonderful atmosphere.
I would also like to express many thanks to Dr. Eng. Lorenz Gabel for his help,
especially in the initial phase of my work. Your friendship and friendly environment, created
by the multitude of interesting conversations, were unforgettable.
I want to emphasize with all my heart my gratitude to Tanja Weber for every moment
during these 3 years! I cannot express in words how much you did for me, not only by helping
me to solve a huge number of different problems during the creation of this work, but also by
your smile, friendship and kind heart that was always open to listen and help in any
circumstances!
I would like to thank Yvonne Hanrahan for reading and correcting parts of this thesis.
I also owe a great deal of gratitude to Krystyna and Zdzisław Stańczyk, and their
daughter Moni for your support and for all the time I spent at your home.
This thesis would not have been possible without you, my dear Friends! I am thankful to all
my friends in Munich, who have made me feel at home here, and to my friends abroad, for the
trips, visits and e-mails, reminding me that friendship remains despite any distance. To write
about your help and support would be overwhelmingly lengthy, so I decided to only mention
your names. I hope we will make more moments to remember! I would like to thank Agatka
Miłosz, Angelica Liguori, Angels Via Estern, Ania Kalita, Ania Górka-Babik, Berenika
Zaraska, Beril Caylak, Chiara Alfano, Cony Wendler Vidal, Cris Burqueño, Elunia
Romej, Gilda Fulco, Elena Serrano Bertos, Kasia Mikła, Martita Lopez, Liz Costa,
Madzia Różańska, Madzia Kuty, Marylka Neubauer, Miriam Olejnik, Monia
Dworecka, Misia Kołodziej, Nuria Riera, Paola Azzarino, Paula Gil, Renijka Załęcka,
Sandrita Berdala, Vale Angeletti, Antonio Sala, Balazs Matuz, Carlos Gomez
Bartolomé, Chen Teng, Dejan Pangercic, Domenico Lorusso, Edu Aguilar Moreno and
his wonderful Family, Franio Lazaro Blasco, Giuliano Garrammone, Fr. Jan Kruczyński, Javi Bueno García, Javi Mulero, Jordi Rivera, José Gardiazabal, José Garzon,
Fr. Józef Zborzil, Juanito Cabezas García, Juli Cocera Cañas, Maciuś Tusz,
Marco Ristic, Marek Babik, Paweł Telega, Pau Goldstein, Rafa Rodriguez,
Raul Tejedor, Ricardo Minguez, Romain Hermenier, Silvio Pasquali, Thomas Wendler
Vidal, Tomaso de Cola and Yves Strittmatter.
I want to emphasize special thanks to Benjamin Gaczkowski for his support,
understanding and encouragement especially in the worst moments of writing of this thesis! I
want to thank you for your help and time, simply being there for me!
Most of all I want to thank all my family, especially my phenomenal brothers Mariusz
and Piotr for being my teachers from the beginning, for their support, help at any time with
all things I needed also from a distance! I would like to thank their wives Marta and Madzia,
as well for being with us and making the family and the time spent together richer and
beautiful!!
At the end I want to thank my parents, the most important people! If I would like to
write here all things for that I owe to thank them, I wouldn't have enough space, but if I wrote
just a few situations, it wouldn't express everything what they did! I write then just one
sentence:
Thank you from all my heart for your Love,
Love which was a source of everything
and brought me everything!!!






All wisdom comes from the LORD and with him it remains forever.
The sand of the seashore, the drops of rain, the days of eternity: who can number
these? Heaven's height, earth's breadth, the depths of the abyss: who can explore
these? Before all things else wisdom was created; and prudent understanding, from
eternity. To whom has wisdom's root been revealed? Who knows her subtleties?
There is but one, wise and truly awe-inspiring, seated upon his throne:
It is the LORD; he created her, has seen her and taken note of her. He has poured her
forth upon all his works, upon every living thing according to his bounty;
he has lavished her upon his friends….
Sir 1, 1-10









Dedicated to
my wonderful Family

Contents

1. Introduction ................................................................................................... 1
1.1. The topic of the thesis ................................ 3
2. Theoretical Background ............................................... 5
2.1. Flavonoids ................................................................................... 5
2.1.1 Structure and nomenclature of flavonoids .......................... 6
2.1.2. Occurrence of flavonoids .................................................... 7
2.1.3. Medicinal properties of flavonoids ..................................................................... 8
2.1.4. Human therapeutic significance of flavonoids ................... 9
2.1.5. Absorption and metabolism of flavonoids ........................................................ 10
2.1.6. Antioxidant properties of flavonoids ................................ 11
2.1.7. Tumors protective activity of flavonoids .......................... 12
2.1.8. Flavonoids as immune modulators ................................... 13
2.1.9. Antiviral activity of flavonoids ......................................... 14
2.1.10. Antimicrobial activity of flavonoids . 15
2.1.11. Toxicity of flavonoids....................................................................................... 16