Adult Stem Cells in Aging, Diseases and Cancer

Description

The functionality of adult tissue stem cells from various organ systems declines during aging. This publication summarizes novel molecular mechanisms responsible for the development of aging-associated deficiencies as discussed by leading experts during the 5th Else Kröner-Fresenius Symposium. It is the first book that explicitly focuses on molecular mechanisms of stem cell aging and its consequences for disease and cancer development including both cell-intrinsic mechanisms as well as aging-induced alterations in the stem cell niche and the systemic environment. Cutting-edge information on stem cells, aging, cancer, and disease make this publication of special interest to basic researchers in the respective fields. Further, it is also intended for medical doctors in the fields of geriatrics, internal medicine, and cancer as it provides a novel understanding of the evolution of tissue dysfunction, diseases and cancer as a consequence of aging.

Informations

• Publié par: S. Karger AG
• Date de parution: 22 décembre 2014
• Nombre de lectures: 0
• EAN13: 9783318027327
• Langue: English
• Poids de l'ouvrage: 1 Mo

Extrait

Adult Stem Cells in Aging, Diseases and Cancer
Else Kröner-Fresenius Symposia
Vol. 5
Series Editor
S. Pahernik Heidelberg
Adult Stem Cells in Aging, Diseases and Cancer
Volume Editor
Karl Lenhard Rudolph Jena
19 figures in color, 2015
_______________________ Karl Lenhard Rudolph Leibniz Institute for Age Research Fritz Lipmann Institute e.V. (FLI) Beutenbergstrasse 11 DE-07745 Jena (Germany)
This book is sponsored by the Else Kröner-Fresenius-Stiftung.
Else Kröner-Fresenius Symposium on Adult Stem Cells in Aging, Diseases, and Cancer (2013: Eisenach, Germany), author.
Adult stem cells in aging, diseases, and cancer/volume editor, Karl Lenhard Rudolph.
p. ; cm. –– (Else Kröner-Fresenius symposia, ISSN 1663-0114; vol. 5)
Includes bibliographical references and indexes.
ISBN 978-3-318-02731-0 (hard cover: alk. paper) –– ISBN 978-3-318-02732-7 (eISBN)
I. Rudolph, K. Lenhard, editor. II. Title. III. Series: Else Kröner-Fresenius symposia ; v. 5. 1663-0114
[DNLM: 1. Adult Stem Cells-physiology––Congresses. 2. Cell Aging––physiology––Congresses. 3. DNA Damage––physiology––Congresses. 4. Neoplasms-genetics––Congresses. 5. Telomere-genetics––Congresses. QU 325]
QH588.S83
616.02'774––dc23
2014040523
Bibliographic Indices. This publication is listed in bibliographic services, including Current Contents ® .
Disclaimer. The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publisher and the editor(s).The appearance of advertisements in the book is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
Drug Dosage. The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any change in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Cover art by Maren Blaschke
© Copyright 2015 by S. Karger AG, P.O. Box, CH-4009 Basel (Switzerland)
www.karger.com
Printed in Germany on acid-free and non-aging paper (ISO 9706) by Kraft Druck, Ettlingen
ISSN 1663-0114
ISBN 978-3-318-02731-0
eISBN 978-3-318-02732-7
Contents
Preface
Pahernik, S. (Heidelberg)
Introduction
Rudolph, K.L. (Jena)
Speakers at the Symposium
Stem Cells in Adult Intestine
Feng, J.; Sperka, T. (Jena)
Molecular Mechanisms of Muscle Stem Cell Aging
Schwörer, S.; Tümpel, S. (Jena)
Mechanism of Functional Alterations in Hematopoietic Stem Cell Aging
Morita, Y. (Jena)
The Microenvironment, Aging and Disease
Geiger, H. (Ulm)
Sestrins in Aging and Metabolism
Tang, D.; Tao, S. (Jena)
Telomeres and Stem Cell Aging
Felix, D.A. (Jena)
DNA Damage and Checkpoint Responses in Adult Stem Cells
Romanov, V. (Jena); Shukla, A.; Ju, Z. (Hangzhou)
Thomas Hell Plays ‘Vertigo’ by György Ligeti
Free Download Available
Author Index
Subject Index
Preface
Adult Stem Cells in Aging, Diseases and Cancer
This book series features the proceedings of the Else Kröner-Fresenius Symposia, which cover clinically relevant topics at the forefront of biomedical research. The meetings should give experts the opportunity to discuss the most recent findings in evolving fields of biomedicine and outline future research strategies.
Today's research is characterized by the accelerated generation of biomedical data, the increasingly interdisciplinary and translational nature of biomedical science as well as the efforts to integrate the data into complex biological systems. These developments emphasize the need for new forums of discussion.
The understanding of stem cell aging in the context of pathological tissue and malignant tumors is highly relevant for future developments in biomedicine. Physiology, modulation and pathology might be promising to open new perspectives to restore organ function lost by disease or physical trauma or to overcome pathophysiological conditions.
In this context, Prof. Dr. Karl Lenhard Rudolph organized the 5th Else Kröner-Fresenius Symposium held at the famous Wartburg Castle near Eisenach in May 2013, a distinguished meeting which focused on adult stem cells in aging, diseases and cancer. The Else Kröner-Fresenius Symposium with world-renowned experts discussed current advances in stem cell aging and illustrated new perspectives from the diverse fields of stem cell research, and how they could be integrated into clinical practice, in particular with respect to inflammatory disease and cancer. The Else Kröner-Fresenius-Stiftung thanks Prof. Dr. Rudolph for his inspiring scientific work and the outstanding personal input in organizing the 5th Else Kröner-Fresenius Symposium with his team.
The Else Kröner-Fresenius-Stiftung
In 1983, Else Kröner (1925-1988) founded the Else Kröner-Fresenius-Stiftung, a nonprofit foundation dedicated to promoting medical science, supporting medical education and providing humanitarian aid.
Else Kröner, née Fernau, was born on May 15, 1925, in Frankfurt am Main, Germany. Her father died when she was only 3 years old. After his death, she lived with her mother in the home of Dr. Eduard Fresenius, a pharmacist and owner of the Hirsch Pharmacy in Frankfurt, who founded the pharmaceutical company Fresenius in 1912. Dr. Eduard Fresenius, whose marriage was childless, took care of Else Fernau. In 1944, she started an internship at the Hirsch Pharmacy and decided to study pharmacy, which was supported by Dr. Eduard Fresenius. In 1946, Dr. Eduard Fresenius died unexpectedly. At this time, Else Fernau had not completed her pharmaceutical education. However, Dr. Eduard Fresenius bequeathed the Hirsch Pharmacy and the Fresenius company to her.
At the age of 21 years, Else Fernau decided, against the advice of many, to take responsibility for the Hirsch Pharmacy and the Fresenius company, which were then experiencing severe financial difficulties during the post-war years. Of the original 400 employees, all but 30 had to be laid off. In her efforts to ensure the survival and force the re-expansion of the company, she was later supported by her husband, Hans Kröner. The company was progressively rebuilt, and the need to maintain it determined all activities.
These important and far-sighted entrepreneurial business decisions in the 1950s and 1960s ensured the successful future development of the company. Decades of growth followed, in particular within the field of dialysis, nutrition and intensive care, leading to an internationally competitive enterprise and market leader in special areas of health care.
Else Kröner led the company until 1981. After the transformation of Fresenius into a stock company, she remained Chairwoman of the Supervisory Board until her death on June 5, 1988. From 1981 to 1992 her husband Hans Kröner led the company as CEO. Thereafter, he significantly shaped the policy of the Else Kröner-Fresenius-Stiftung, of which he was chairman of the board from 1995 to 2005.
Today, the Fresenius group, of which the Else Kröner-Fresenius-Stiftung is the leading share holder, is an international healthcare conglomerate with products and services for dialysis, hospital, and medical care of patients. The Fresenius group currently employs over 200,000 people in more than 100 countries and generates annual sales of over EUR 20 billion.
Else Kröner entrusted nearly her entire property to the foundation. She laid down that its financial resources should be employed to promote medical science, advance health care and provide humanitarian aid. It is in accordance with her vision and requirements that the Else Kröner-Fresenius-Stiftung continues to put the founder's fortune at the service of nonprofit projects and objectives. The symposia are published as part of the foundation's commitment to the advancement of medical research and treatment.
Sascha Pahernik , Heidelberg
Member of the Scientific Committee of the Else Kröner-Fresenius-Stiftung
Series Editor
Rudolph KL (ed): Adult Stem Cells in Aging, Diseases and Cancer. Else Kröner-Fresenius Symp. Basel, Karger, 2015, vol 5, pp 1-2 (DOI: 10.1159/000366564)
______________________
Introduction
Karl Lenhard Rudolph
Leibniz Institute for Age Research, Fritz Lipmann Institute, Jena, Germany
Stem cells are present in almost all tissues of the adult human body. Aging-induced impairments in the functionality of stem cells in ad