Applied Pharmacology E-Book

Stan Bardal, Jason Waechter, Doug Martin

Description

Applied Pharmacology provides the essential details that are required for a solid understanding of pharmacology: how the drugs work, why side effects occur, and how the drugs are used clinically. Drs. Stan Bardal, Jason Waechter, and Doug Martin integrate the experience of the pharmacologist and the physician for a clinical focus that ensures a complete understanding of pharmacology...in print and online.

• Find information quickly and compare and contrast drugs easily thanks to a clear and consistent format without extraneous material.
• Apply basic pharmacology to clinical situations through integrated text. Enhance your learning with "For Your Information" sections detailing history and anecdotes for many agents within a given drug class.
• Find a wealth of additional resources online at www.studentconsult.com.
• Learn the essential details of pharmacology and enhance your understanding through an entirely new, fantastic art program.

Informations

• Publié par: Saunders
• Date de parution: 10 novembre 2010
• Nombre de lectures: 0
• EAN13: 9781437735789
• Langue: English
• Poids de l'ouvrage: 3 Mo

Extrait

Applied Pharmacology

Stan K. Bardal, BSc (Pharm), MBA, PhD
Senior Instructor, Division of Medical Sciences, University of Victoria, Victoria, British Columbia
Instructor, Anesthesiology Pharmacology and Therapeutics and Island Medical Program, University of British Columbia, Vancouver, British Columbia, Canada

Jason E. Waechter, BSc, MD, FRCP(C)
Clinical Assistant Professor, Departments of Critical Care and Anesthesiology, University of Calgary, Calgary, Alberta, Canada

Douglas S. Martin, PhD
Professor, Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, South Dakota, United States
Saunders
Front Matter

Applied Pharmacology
Stan K. Bardal, BSc (Pharm), MBA, PhD
Senior Instructor
Division of Medical Sciences
University of Victoria
Victoria, British Columbia
and
Instructor, Anesthesiology
Pharmacology and Therapeutics and Island Medical Program
University of British Columbia
Vancouver, British Columbia
Canada
Jason E. Waechter, BSc, MD, FRCP(C)
Clinical Assistant Professor
Departments of Critical Care and Anesthesiology
University of Calgary
Calgary, Alberta
Canada
Douglas S. Martin, PhD
Professor, Basic Biomedical Sciences
Sanford School of Medicine
University of South Dakota
Vermillion, South Dakota
United States
Copyright

3251 Riverport Lane
St. Louis, Missouri 63043
APPLIED PHARMACOLOGY ISBN: 978-1-4377-0310-8
Copyright © 2011 by Saunders, an imprint of Elsevier Inc.
All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any information storage and retrieval system, without permission in writing from the publisher. Details on how to seek permission, further information about the Publisher’s permissions policies and our arrangements with organizations such as the Copyright Clearance Center and the Copyright Licensing Agency, can be found at our website: www.elsevier.com/permissions .
This book and the individual contributions contained in it are protected under copyright by the Publisher (other than as may be noted herein).


Notices
Knowledge and best practice in this field are constantly changing. As new research and experience broaden our understanding, changes in research methods, professional practices, or medical treatment may become necessary.
Practitioners and researchers must always rely on their own experience and knowledge in evaluating and using any information, methods, compounds, or experiments described herein. In using such information or methods they should be mindful of their own safety and the safety of others, including parties for whom they have a professional responsibility.
With respect to any drug or pharmaceutical products identified, readers are advised to check the most current information provided (i) on procedures featured or (ii) by the manufacturer of each product to be administered, to verify the recommended dose or formula, the method and duration of administration, and contraindications. It is the responsibility of practitioners, relying on their own experience and knowledge of their patients, to make diagnoses, to determine dosages and the best treatment for each individual patient, and to take all appropriate safety precautions.
To the fullest extent of the law, neither the Publisher nor the authors, contributors, or editors, assume any liability for any injury and/or damage to persons or property as a matter of products liability, negligence or otherwise, or from any use or operation of any methods, products, instructions, or ideas contained in the material herein.
Library of Congress Cataloging-in-Publication Data
Bardal, Stan K.
Applied pharmacology / Stan K. Bardal, Jason E. Waechter, Douglas S. Martin.
p. ; cm.
Includes index.
ISBN 978-1-4377-0310-8 (pbk. : alk. paper) 1. Clinical pharmacology—Textbooks. I. Waechter, Jason E. II. Martin, Douglas S. III. Title.
[DNLM: 1. Pharmacology, Clinical. QV 38]
RM301.28.B365 2011
615′.1—dc22
2010026131
Acquisitions Editors: Kate Dimock, Madelene Hyde
Developmental Editor: Barbara Cicalese
Publishing Services Manager: Patricia Tannian
Team Manager: Radhika Pallamparthy
Senior Project Manager: Sarah Wunderly
Project Manager: Joanna Dhanabalan
Design Direction: Steven Stave
Printed in China
Last digit is the print number: 9 8 7 6 5 4 3 2 1
Dedication
This work is dedicated to my family, most notably my father, Konrad, for his continued support throughout the years; my wife, Jen, for her love and understanding; and my son Kalman, my inspiration for all future endeavors.

Stan Bardal
To my fiancée, Andrea Neilson

Jason Waechter
To my wife, Joanne, and children, Darren and Karissa, thank you for your love, and patience, without which my career in pharmacology would not have been possible. Thank you to Dr. Robert McNeill, a mentor and friend, who guided me into pharmacology.

Doug Martin
Preface
This textbook is designed to provide a concise yet comprehensive review of pharmacology, with an emphasis on information that is useful for clinicians in training or in practice. With its emphasis on basic science and clinical pharmacology, as well as evidence-based practice, this book is intended to be used from the beginning of students’ training through their clinical years and beyond.
The book is divided into two sections. The Introduction covers basic pharmacologic principles such as pharmacodynamics, pharmacokinetics, autonomic pharmacology, and toxicology, as well as a number of more clinically oriented topics such as drug interactions, impact of age on pharmacology, drug discovery and evaluation, pharmacogenetics, herbal medicines, and addiction.
The Drug Classes section is divided into individual drug classes, which are grouped into larger sections, typically reflective of the body system (e.g., cardiovascular, pulmonary) or indication (e.g., psychiatry, infectious diseases) for which the drug is most commonly used. Each drug chapter follows a similar template as outlined below:

Title (Drug name or class)

Description

Brief description of the drug or class of drug

Prototype and Common Drugs

Most important drug names
Nomenclature is boldfaced, if applicable (e.g., -olol for beta blockers)

MOA (Mechanism of Action)

Physiology and biochemical action of the drug or drug class
How and why the effects of the drug occur
Mechanisms of Resistance

Pharmacokinetics

Major pharmacokinetic issues with the drug class or a given drug. This is not intended to be comprehensive but will cover the most important issues a practioner might face when prescribing a given drug, including the route of metabolism, clinically important drug interactions, and issues pertaining to administration.
If the half-life is at an extreme or an exception, it will be listed
If the drug has a narrow therapeutic index or is potentially toxic, elimination will be described
If the drug has special routes of administration, these will be described

Indications

Clinical conditions for which the drug is used

Contraindications

Situations for which the drug should not ( relative contraindication) or must not ( absolute contraindication) be used

Side Effects

Side effects of the drug or drug class
Explanations of why side effects occur, when mechanisms are known

Important Notes

Additional information that is considered to be essential for effective prescribing

Advanced

Details that pertain to pharmacokinetics, pharmacodynamics, drug interactions, pharmacogenetics, or other drug-specific details
Clinical details, including rare diseases, complicated mechanisms, theoretical concerns, or other details

Evidence

The focus is on recent, high-quality, systematic reviews. If such reviews are not available, evidence will not be included.
The actions of the drug or drug class must be isolatable in the systematic review; therefore indications such as cancer, in which combination therapy is used, will have a smaller amount of available evidence.
Treatment of infectious diseases, which is typically dictated by temporal and regional susceptibility patterns, will also have less available evidence.

FYI

Notes of interest to help the reader remember or understand other information

Faculty Resources
An image collection and test bank are available for your use when teaching via Evolve. Contact your local sales representative for more information, or go directly to the Evolve website to request access: http://evolve.elsevier.com.

Acknowledgments
The authors would like to acknowledge the dedication and support of Elsevier to this project, most notably the work of Kate Dimock, Madelene Hyde, and Barbara Cicalese.
Table of Contents
Front Matter
Copyright
Dedication
Preface
Section I: Introduction
Chapter 1: Basic Principles and Pharmacodynamics
Chapter 2: Pharmacokinetics
Chapter 3: Autonomic Pharmacology
Chapter 4: Drug Interactions
Chapter 5: Im