Braunwald s Heart Disease E-Book
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Braunwald’s Heart Disease remains your indispensable source for definitive, state-of-the-art answers on every aspect of contemporary cardiology. Edited by Drs. Robert O. Bonow, Douglas L. Mann, Douglas P. Zipes, and Peter Libby, this dynamic, multimedia reference helps you apply the most recent knowledge in molecular biology and genetics, imaging, pharmacology, interventional cardiology, electrophysiology, and much more. Weekly updates online, personally selected by Dr. Braunwald, continuously keep you current on the most important new developments affecting your practice. Enhanced premium online content includes new dynamic cardiac imaging videos, heart sound recordings, and podcasts. With sweeping updates throughout, and contributions from a "who’s who" of global cardiology, Braunwald’s is the cornerstone of effective practice.

  • Continuously access the most important new developments affecting your practice with weekly updates personally selected by Dr. Braunwald, including focused reviews, "hot off the press" commentaries, and late-breaking clinical trials.
  • Practice with confidence and overcome your toughest challenges with advice from the top minds in cardiology today, who synthesize the entire state of current knowledge and summarize all of the most recent ACC/AHA practice guidelines.
  • Locate the answers you need fast thanks to a user-friendly, full-color design with more than 1,200 color illustrations.
  • Search the complete contents online at
  • Stay on top of the latest advances in molecular imaging, intravascular ultrasound, cardiovascular regeneration and tissue engineering, device therapy for advanced heart failure, atrial fibrillation management, structural heart disease, Chagasic heart disease, ethics in cardiovascular medicine, the design and conduct of clinical trials, and many other timely topics.
  • Hone your clinical skills with new dynamic cardiac imaging videos, heart sound recordings, and podcasts at


Artery disease
Cardiac dysrhythmia
Functional disorder
ST elevation
Systemic lupus erythematosus
Atrial fibrillation
Myocardial infarction
Cardiac monitoring
Cardiopulmonary rehabilitation
Cardiovascular magnetic resonance imaging
Off-pump coronary artery bypass
Endocrine disease
Myotonic dystrophy
Global burden of disease
Sudden cardiac death
Percutaneous coronary intervention
Molecular imaging
Unstable angina
Restrictive cardiomyopathy
Valvular heart disease
Acute coronary syndrome
End stage renal disease
Superior vena cava syndrome
Left ventricular hypertrophy
Preventive medicine
Mitral regurgitation
Ventricular septal defect
Congenital heart defect
Essential hypertension
Trauma (medicine)
Cardiac stress test
Chronic kidney disease
Ventricular tachycardia
Terminal illness
Pulmonary hypertension
Mitral stenosis
Antiarrhythmic agent
Random sample
Dilated cardiomyopathy
Hypertrophic cardiomyopathy
Blood flow
Coronary catheterization
Low molecular weight heparin
Deep vein thrombosis
Infective endocarditis
Chest pain
Cardiovascular disease
Nutrition disorder
Rheumatic fever
Ecological succession
Aerobic exercise
Tissue engineering
Single photon emission computed tomography
Smoking cessation
Aortic dissection
Health care
Heart failure
Heart murmur
Pulmonary embolism
General practitioner
Coronary artery bypass surgery
Aortic valve stenosis
Physical exercise
Diabetes mellitus type 2
Coronary circulation
Orthostatic hypotension
Artificial pacemaker
Heart disease
Angina pectoris
Ischaemic heart disease
Cardiac arrest
Circulatory system
Metabolic syndrome
X-ray computed tomography
Diabetes mellitus
Magnetic resonance imaging
Major depressive disorder
Chagas disease


Publié par
Date de parution 25 février 2011
Nombre de lectures 3
EAN13 9781437727708
Langue English
Poids de l'ouvrage 10 Mo

Informations légales : prix de location à la page 0,0775€. Cette information est donnée uniquement à titre indicatif conformément à la législation en vigueur.


Braunwald’s Heart Disease
A Textbook of Cardiovascular Medicine
Ninth Edition

Robert O. Bonow, MD
Max and Lilly Goldberg Distinguished Professor of Cardiology, Vice Chairman, Department of Medicine, Director, Center for Cardiac Innovation, Northwestern University Feinberg School of Medicine, Chicago, Illinois

Douglas L. Mann, MD
Lewin Chair and Professor of Medicine, Cell Biology, and Physiology, Chief, Division of Cardiology, Washington University School of Medicine in St. Louis, Cardiologist-in-Chief, Barnes-Jewish Hospital, Saint Louis, Missouri

Douglas P. Zipes, MD
Distinguished Professor, Professor Emeritus of Medicine, Pharmacology, and Toxicology, Director Emeritus, Division of Cardiology and the Krannert Institute of Cardiology, Indiana University School of Medicine, Indianapolis, Indiana

Peter Libby, MD
Mallinckrodt Professor of Medicine, Harvard Medical School, Chief, Cardiovascular Division, Brigham and Women’s Hospital, Boston, Massachusetts
Front Matter

Braunwald’s Heart Disease
A Textbook of Cardiovascular Medicine
Edited by
Robert O. Bonow, MD
Max and Lilly Goldberg Distinguished Professor of Cardiology
Vice Chairman, Department of Medicine
Director, Center for Cardiac Innovation
Northwestern University Feinberg School of Medicine
Chicago, Illinois
Douglas L. Mann, MD
Lewin Chair and Professor of Medicine, Cell Biology, and Physiology
Chief, Division of Cardiology
Washington University School of Medicine in St. Louis
Barnes-Jewish Hospital
Saint Louis, Missouri
Douglas P. Zipes, MD
Distinguished Professor
Professor Emeritus of Medicine, Pharmacology, and Toxicology
Director Emeritus, Division of Cardiology and the Krannert Institute of Cardiology
Indiana University School of Medicine
Indianapolis, Indiana
Peter Libby, MD
Mallinckrodt Professor of Medicine
Harvard Medical School
Chief, Cardiovascular Division
Brigham and Women’s Hospital
Boston, Massachusetts

Founding Editor and Online Editor
Eugene Braunwald, MD, MD(Hon), ScD(Hon), FRCP
Distinguished Hersey Professor of Medicine
Harvard Medical School
Chairman, TIMI Study Group
Brigham and Women’s Hospital
Boston, Massachusetts

1600 John F. Kennedy Blvd.
Ste. 1800
Philadelphia, PA 19103-2899
Two-Volume Set: 978-1-4377-2708-1
Copyright © 2012, 2008, 2005, 2001, 1997, 1992, 1988, 1984, 1980 by Saunders, an imprint of Elsevier Inc. International Edition: 978-0-8089-2436-4
No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any information storage and retrieval system, without permission in writing from the publisher. Details on how to seek permission, further information about the Publisher’s permissions policies and our arrangements with organizations such as the Copyright Clearance Center and the Copyright Licensing Agency, can be found at our website: .
This book and the individual contributions contained in it are protected under copyright by the Publisher (other than as may be noted herein).

Knowledge and best practice in this field are constantly changing. As new research and experience broaden our understanding, changes in research methods, professional practices, or medical treatment may become necessary.
Practitioners and researchers must always rely on their own experience and knowledge in evaluating and using any information, methods, compounds, or experiments described herein. In using such information or methods they should be mindful of their own safety and the safety of others, including parties for whom they have a professional responsibility.
With respect to any drug or pharmaceutical products identified, readers are advised to check the most current information provided (i) on procedures featured or (ii) by the manufacturer of each product to be administered, to verify the recommended dose or formula, the method and duration of administration, and contraindications. It is the responsibility of practitioners, relying on their own experience and knowledge of their patients, to make diagnoses, to determine dosages and the best treatment for each individual patient, and to take all appropriate safety precautions.
To the fullest extent of the law, neither the Publisher nor the authors, contributors, or editors, assume any liability for any injury and/or damage to persons or property as a matter of products liability, negligence or otherwise, or from any use or operation of any methods, products, instructions, or ideas contained in the material herein.
Library of Congress Cataloging-in-Publication Data
Robert O. Bonow … [et al.].—9th ed.
p. ; cm.
Heart disease
Includes bibliographical references and index.
ISBN 978-1-4377-0398-6 (single volume : hardcover : alk. paper)—ISBN 978-1-4377-2708-1 (two-volume set : hardcover : alk. paper)—ISBN 978-0-8089-2436-4 (international ed. : hardcover : alk. paper)
1. Heart—Diseases. 2. Cardiology. I. Braunwald, Eugene, 1929- II. Bonow, Robert O. III. Title: Heart disease.
[DNLM: 1. Heart Diseases. 2. Cardiovascular Diseases. WG 210]
RC681.H36 2012
Executive Publisher: Natasha Andjelkovic
Developmental Editor: Anne Snyder
Publishing Services Manager: Patricia Tannian
Team Manager: Radhika Pallamparthy
Senior Project Manager: Sarah Wunderly
Project Manager: Joanna Dhanabalan
Design Direction: Steven Stave
Printed in China
Last digit is the print number: 9 8 7 6 5 4 3 2 1
We are proud to dedicate the ninth edition of Braunwald’s Heart Disease to its founder, Eugene Braunwald, MD. The first edition of this work, published 30 years ago, established a standard of excellence that is rarely, if ever, achieved in publishing. Dr. Braunwald personally wrote half of the book and expertly edited the rest. He did the same for the next four editions, taking a 6-month sabbatical every 4 to 5 years to accomplish that. For the sixth edition, published in 2001, he invited two of us (PL, DPZ) to share the experience with him, increasing the editors by one (ROB) for the seventh edition. A new editor (DLM) joined for the eighth edition, and Dr. Braunwald no longer directly participated in the day-to-day editing of the print text, while still contributing some of the key chapters. However, he kept his finger on the pulse of the text and for that edition began twice-weekly electronic updates. Incorporating the most recent research, reviews, and opinions into the electronic text has continued through this ninth edition, making Braunwald’s Heart Disease truly a living work and setting it apart from other texts. Dr. Braunwald, through his research, teaching, and mentorship, has shaped much of contemporary cardiovascular medicine, and it is with gratitude and admiration that we dedicate this edition of his work to him.

Robert O. Bonow

Douglas L. Mann

Douglas P. Zipes

Peter Libby
The editors gratefully acknowledge communication and correspondence from colleagues all over the world who have offered insightful suggestions to improve this text. We particularly wish to acknowledge the following individuals who have provided careful and studious commentary on numerous chapters: Shabnam Madadi, MD, Cardiac Imaging Center, Shahid Rajaei Heart Center, Tehran, Iran; Azin Alizadeh Asl, MD, Tabriz University of Medical Sciences and Madani Heart Hospital, Tabriz, Iran; Leili Pourafkari, MD, Razi Hospital, Tabriz, Iran; Banasiak Waldemar, MD, Centre for Heart Disease, Military Hospital, Wroclaw, Poland; Carlos Benjamín Alvarez, MD, PhD, Sacré Coeur Institute, Buenos Aires, Argentina; Elias B. Hanna, MD, Division of Cardiology, Louisiana State University, New Orleans, Louisiana.
We are also indebted to Dr. Jun-o Deguchi, Dr. Michael Markl, Dr. Vera Rigolin, and Dr. Carol Warnes for the images used on the cover.
Dr. Libby thanks Sara Karwacki for expert editorial assistance.
Dedication 2
Pat, Rob, and Sam
Laura, Stephanie, Jonathan, and Erica
Joan, Debra, Jeffrey, and David
Beryl, Oliver, and Brigitte

William T. Abraham, MD, Professor of Internal Medicine, Physiology, and Cell Biology; Chair of Excellence in Cardiovascular Medicine; Director, Division of Cardiovascular Medicine; Deputy Director, The Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio
Devices for Monitoring and Managing Heart Failure

Michael A. Acker, MD, Professor of Surgery, University of Pennsylvania School of Medicine; Chief, Division of Cardiovascular Surgery, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania
Surgical Management of Heart Failure

Michael J. Ackerman, MD, PhD, Professor of Medicine, Pediatrics, and Pharmacology; Consultant, Cardiovascular Diseases and Pediatric Cardiology; Director, Long QT Syndrome Clinic and the Windland Smith Rice Sudden Death Genomics Laboratory, Mayo Clinic, Rochester, Minnesota
Genetics of Cardiac Arrhythmias

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