Braunwald's Heart Disease E-Book

Douglas L. Mann, Robert O. Bonow, Douglas P. Zipes, Peter Libby

Description

Ideal for cardiologists who need to keep abreast of rapidly changing scientific foundations, clinical research results, and evidence-based medicine, Braunwald’s Heart Disease is your indispensable source for definitive, state-of-the-art answers on every aspect of contemporary cardiology, helping you apply the most recent knowledge in personalized medicine, imaging techniques, pharmacology, interventional cardiology, electrophysiology, and much more!

• Practice with confidence and overcome your toughest challenges with advice from the top minds in cardiology today, who synthesize the entire state of current knowledge and summarize all of the most recent ACC/AHA practice guidelines.
• Locate the answers you need fast thanks to a user-friendly, full-color design with more than 1,200 color illustrations.

• Learn from leading international experts, including 53 new authors. Explore brand-new chapters, such as Principles of Cardiovascular Genetics and Biomarkers, Proteomics, Metabolomics, and Personalized Medicine.
• Access new and updated guidelines covering Diseases of the Aorta, Peripheral Artery Diseases, Diabetes and the Cardiovascular System, Heart Failure, and Valvular Heart Disease.
• Stay abreast of the latest diagnostic and imaging techniques and modalities, such as three-dimensional echocardiography, speckle tracking, tissue Doppler, computed tomography, and cardiac magnetic resonance imaging.
• Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability.

Informations

• Publié par: Saunders
• Date de parution: 30 juillet 2014
• Nombre de lectures: 1
• EAN13: 9780323290647
• Langue: English
• Poids de l'ouvrage: 29 Mo

Extrait

Braunwald's Heart Disease

A Textbook Of Cardiovascular Medicine

TENTH EDITION

Edited by

Douglas L. Mann, MD

Lewin Chair and Professor of Medicine, Cell Biology, and Physiology Chief, Division of Cardiology Washington University School of Medicine in St. Louis Cardiologist-in-Chief Barnes-Jewish Hospital St. Louis, Missouri

Douglas P. Zipes, MD

Distinguished Professor Professor Emeritus of Medicine, Pharmacology, and Toxicology Director Emeritus, Division of Cardiology and the Krannert Institute of Cardiology Indiana University School of Medicine Indianapolis, Indiana

Peter Libby, MD

Mallinckrodt Professor of Medicine Harvard Medical School Chief, Cardiovascular Medicine Division Brigham and Women's Hospital Boston, Massachusetts

Robert O. Bonow, MD, MS

Max and Lilly Goldberg Distinguished Professor of Cardiology Vice Chairman, Department of Medicine Director, Center for Cardiac Innovation Northwestern University Feinberg School of Medicine Chicago, Illinois Founding Editor and Online Editor

Eugene Braunwald, MD, MD(Hon), ScD(Hon), FRCP

Distinguished Hersey Professor of Medicine Harvard Medical School Founding Chairman, TIMI Study Group Brigham and Women's Hospital Boston, Massachusetts

Table of Contents

Cover image

Title page

Copyright

Dedication

Acknowledgments

Contributors

Preface to the Tenth Edition

Preface—Adapted from the First Edition

Video Contents

Look for these other titles in the Braunwald's Heart Disease Family Part I Fundamentals of Cardiovascular Disease

1 Global Burden of Cardiovascular Disease

Shifting Burden of Cardiovascular Disease

Epidemiologic Transition in Predominant Causes of Death

Current Variations in the Global Burden of Cardiovascular Disease

Risk Factors

Economic Burden

Cost-Effective Solutions

Summary and Conclusions

References

2 Heart Disease in Varied Populations

Changing Demographics of the U.S. Population

Distribution of Known Risk Factors for Heart Disease

Coronary Heart Disease

Hypertension

Heart Failure

Summary

References

3 Ethics in Cardiovascular Medicine

Informed Consent and Shared Decision Making

End-of-Life Care

Ethics of Clinical Research

Resource Allocation

Conflict of Interest

Conclusions

References

4 Clinical Decision Making in Cardiology

Diagnostic Decision Making: General Considerations

Diagnostic Testing

Therapeutic Decision Making

Accuracy of Study Results

Cognitive Errors

Shared Decision Making

Systems of Care

Conclusions

Classic Readings

References

5 Measurement and Improvement of Quality of Care: Relevance to Cardiovascular

Clinical Practice

Defining Quality of Care

Measuring Health Care Quality and Uses of Quality Measurements

Conclusions

References

6 Critical Evaluation of Clinical Trials

Constructing the Research Question

Clinical Trial Design

Key Issues

Measures and Detection of Treatment Effect

Future Perspectives

References

Part II Genetics and Personalized Medicine

7 Personalized and Precision Cardiovascular Medicine

Assessment of Disease Risk: Family Health History and Health Risk Assessments

A Genomic Toolbox for Personalized and Precision Medicine

Gene Expression

Personalized and Precision Cardiovascular Medicine: Clinical Potential

Barriers and Solutions to the Integration of Genomics Into Cardiovascular Medicine

Future Perspective: Toward Personalized and Precision Cardiovascular Medicine

References

8 Principles of Cardiovascular Genetics

Inherited Basis for the Variation in Risk for Cardiovascular Disease

A Brief Primer on Molecular Biology

Modes of Inheritance

Approaches to Discovering the Inherited Basis for Cardiovascular Disease

Illustrative Examples

Clinical Application of Genetic Findings

Future Directions

Acknowledgment

References

9 Drug Therapeutics and Personalized Medicine

Importance of Correct Drug Use

The Key Decision in Drug Therapy: Risk Versus Benefit

Mechanisms Underlying Variability in Drug Action

Molecular and Genetic Basis for Variable Drug Response

Optimizing Drug Doses

Future Challenges

References

10 Biomarkers, Proteomics, Metabolomics, and Personalized Medicine

What is a Biomarker?

Introduction to Proteomics and Metabolomics

Overview of the Discovery Process

Clinical Measures of Biomarker Performance

Conclusion

References

Part III Evaluation of the Patient

11 The History and Physical Examination: An Evidence-Based Approach

The History

The General Physical Examination

The Cardiovascular Examination

Integrated, Evidence-Based Approach to Specific Cardiac Disorders

Future Directions

Acknowledgments

References

12 Electrocardiography

The Normal Electrocardiogram

The Abnormal Electrocardiogram

Clinical Issues in Electrocardiographic Interpretation

Future Perspectives

References

References

13 Exercise Testing

Physiology of Exercise Testing

Technical Aspects of Exercise Testing

Exercise Testing in Patients with Coronary Artery Disease

Exercise Testing in Patients with Nonatherosclerotic Heart Disease

Additional Uses of Exercise Testing

Acknowledgment

References

Classic Reading List

References

14 Echocardiography

Principles of Ultrasound and Instrumentation

Principles of Doppler Imaging

The Standard Adult Transthoracic Echocardiographic Examination

Transesophageal Echocardiography

Three-Dimensional Echocardiography

Echocardiography in the Context of Cardiac Imaging

Myocardial Infarction

Cardiomyopathies

Stress Echocardiography

Valvular Heart Disease (see Chapter 63)

Pericardial Disease (see Chapter 71)

Diseases of the Aorta (see Chapter 57)

Infective Endocarditis (see Chapter 64)

Systemic Diseases and Echocardiography

Pulmonary Hypertension (see Chapter 74)

Cardiac Masses

Congenital Heart Disease in Adults (see Chapter 62)

Cardiac Procedures and Future Directions

References

References

15 The Chest Radiograph in Cardiovascular Disease

Technical Considerations

The Chest Radiograph in Heart Disease

Conclusion

References

16 Nuclear Cardiology

Technical Aspects of Image Acquisition, Display, and Interpretation

Myocardial Blood Flow, Myocardial Metabolism, and Ventricular Function

Disease Detection, Risk Stratification, and Clinical Decision Making

Molecular Imaging of the Cardiovascular System

References

References

17 Cardiovascular Magnetic Resonance Imaging

Basic Principles of Magnetic Resonance Imaging

Patient Safety in Cardiac Magnetic Resonance

Cardiac Magnetic Resonance Assessment of Specific Disorders and Conditions

Novel Cardiac Magnetic Resonance Imaging Techniques

Future Perspectives

References

References

18 Cardiac Computed Tomography

Patient Preparation and Scanning Sequence

Cardiac Computed Tomography Anatomy

Clinical Indications

Incidental Scan Findings

Training and Certification

References

References

19 Cardiac Catheterization

Indications for Diagnostic Cardiac Catheterization

Technical Aspects of Cardiac Catheterization

Hemodynamic Data

Adjunctive Diagnostic Techniques

Complications Associated with Cardiac Catheterization

Future Perspectives

References

References

20 Coronary Arteriography and Intracoronary Imaging

Overview and Background

Indications and Contraindications for Coronary Arteriography

Technique of Coronary Arteriography

Intracoronary Imaging

Future Perspectives

References

References

Part IV Heart Failure