Cancer Screening and Genetics, An Issue of Surgical Clinics

Christopher L. Wolfgang

Description

Cancer Screening and Genetics is reviewed extensively in this important Surgical Clinics of North America issue. Articles include: Cancer Genetics and Implications for Clinical Management; Epigenetics and Cancer; Screening and Early Detection of Cancer: Successes and Failures; Screening for Lung Cancer; Screening for Breast Cancer; Viral Hepatitis and Hepatocellular Cancer: How Should Patients Be Screened?; Screening for Pancreatic Cancer: Where Do We Stand?; Hereditary Colorectal Cancer: Genetics and Screening; Personalized Approach to Gastrointestinal Cancers; Screening for Colorectal Cancer; Screening for Prostate Cancer: Why the Controversy?; Gastric Cancer: East versus West—Is screening and early detection the difference?; and more!

Sujets

• Médecine
• Médecine Générale
• Surgery
• Medical

Informations

• Publié par: Elsevier
• Date de parution: 03 septembre 2015
• Nombre de lectures: 0
• EAN13: 9780323401074
• Langue: English
• Poids de l'ouvrage: 2 Mo

Extrait

Clinics Review Articles Surgical Clinics of North America
Cancer Screening and Genetics

Christopher L. Wolfgang, MD, PhD
Hepatobiliary and Pancreatic Surgery, Paul K. Neumann Professor of Pancreatic Cancer Research, Professor of Surgery, Pathology and Oncology, Johns Hopkins University, Baltimore, MD, USA
ISSN  0039-6109 Volume 95 • Number 5 • October 2015
Elsevier
Table of Contents
Cover image
Title page
Copyright
Contributors
Consulting Editor
Editor
Authors
Forthcoming Issues
Forthcoming Issues
Recent Issues
Foreword: Cancer Screening and Genomics
Preface
Background
Cancer Genetics and Implications for Clinical Management
Key points
Introduction
Understanding the cancer genome landscape and translating advances for therapeutic gain
Driver versus passenger mutations
Mutational signatures in cancer
Rationale of genotype-guided medicine
Managing tumor heterogeneity and resistance to targeted therapy
Advancing molecular phenotype–guided therapy in pancreatic cancer
Individualized therapy initiatives
Inherited susceptibility of cancer in the era of next-generation sequencing
Exceptional responders
Summary
The Triple-Code Model for Pancreatic Cancer
Key points
Cross talk between genetics and epigenetics as a promising paradigm in pancreatology
Mechanistic basis of epigenetics: the nucleosome
Marking the genome by methylation
Epigenetic regulation by noncoding RNAs
Shaping gene expression through nuclear architecture
Epigenetics opens a new era for pancreatic cancer markers and novel therapeutic modalities
Summary
Principles of Cancer Screening
Key points
Introduction
Performance characteristics of screening tests
Measures of screening benefit
Common biases in assessing the benefits of screening
Harms of screening
Cost-effectiveness and targeted screening
Current recommended cancer screening tests in North America
Screening and Early Detection
Specific Diseases
Lung Cancer Screening
Key points
Introduction
Risks and harms of lung cancer screening
Practice of lung cancer screening
Summary
Colorectal Cancer Screening
Key points
Introduction: extent of the disease
Screening techniques and options
Clinical outcomes
Complications and concerns
Summary
Breast Cancer Screening
Key points
Introduction
Screening techniques and options
Personalized breast cancer screening
Complications and concerns
Summary
Screening for Viral Hepatitis and Hepatocellular Cancer
Key points
Screening for hepatitis B virus infection
Screening for hepatitis C virus infection
Diagnosing other viral hepatitides
Screening for hepatocellular carcinoma
When to obtain a liver biopsy to diagnose hepatocellular carcinoma
Prostate Cancer Screening and the Associated Controversy
Key points
Introduction
Screening techniques and options
Clinical outcomes
Complications and concerns
Summary
Screening for Pancreatic Cancer
Key points
Introduction
How early does pancreatic cancer have to be detected for cure?
Target lesions
Who is at risk of developing pancreatic cancer? Who should be screened?
How should suspected lesions be managed?
Screening and Early Detection of Gastric Cancer
Key points
Gastric cancer epidemiology: mortality, incidence between east and west
Risk factors
Gastric cancer screening effect: early detection and the Asian experience
Difference of treatment strategy
Genetic disparity
Summary
Hereditary Colorectal Cancer
Key points
Introduction
Lynch syndrome
Familial adenomatous polyposis
MUTYH-associated polyposis
Summary
Personalized Approaches to Gastrointestinal Cancers
Key points
Introduction
Current concerns and limitations of diagnosis and therapy
Personalized treatment of pancreatic cancers
Personalized treatment of gastrointestinal stromal tumors
Personalized treatment in colorectal cancer
Personalized treatment in gastric cancer
Prognosis
Summary
Index
Copyright
ELSEVIER
1600 John F. Kennedy Boulevard • Suite 1800 • Philadelphia, Pennsylvania, 19103-2899
http://www.surgical.theclinics.com
SURGICAL CLINICS OF NORTH AMERICA Volume 95, Number 5
October 2015 ISSN 0039–6109, ISBN-13: 978-0-323-40106-7
Editor: John Vassallo, [e-mail]
Developmental Editor: Colleen Viola
© 2015 Elsevier Inc. All rights reserved.
This periodical and the individual contributions contained in it are protected under copyright by Elsevier, and the following terms and conditions apply to their use:
Photocopying
Single photocopies of single articles may be made for personal use as allowed by national copyright laws. Permission of the Publisher and payment of a fee is required for all other photocopying, including multiple or systematic copying, copying for advertising or promotional purposes, resale, and all forms of document delivery. Special rates are available for educational institutions that wish to make photocopies for non-profit educational classroom use. For information on how to seek permission visit www.elsevier.com/permissions or call: ([phone] (UK)/([phone] (USA).
Derivative Works
Subscribers may reproduce tables of contents or prepare lists of articles including abstracts for internal circulation within their institutions. Permission of the Publisher is required for resale or distribution outside the institution. Permission of the Publisher is required for all other derivative works, including compilations and translations (please consult www.elsevier.com/permissions ).
Electronic Storage or Usage
Permission of the Publisher is required to store or use electronically any material contained in this periodical, including any article or part of an article (please consult www.elsevier.com/permissions ). Except as outlined above, no part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, without prior written permission of the Publisher.
Notice
No responsibility is assumed by the Publisher for any injury and/or damage to persons or property as a matter of products liability, negligence or otherwise, or from any use or operation of any methods, products, instructions or ideas contained in the material herein. Because of rapid advances in the medical sciences, in particular, independent verification of diagnoses and drug dosages should be made.
Although all advertising material is expected to conform to ethical (medical) standards, inclusion in this publication does not constitute a guarantee or endorsement of the quality or value of such product or of the claims made of it by its manufacturer.
Surgical Clinics of North America (ISSN 0039–6109) is published bimonthly by Elsevier Inc., 360 Park Avenue South, New York, NY 10010-1710. Months of publication are February, April, June, August, October, and December. Business and Editorial Offices: 1600 John F. Kennedy Blvd., Suite 1800, Philadelphia, PA 19103-2899. Periodicals postage paid at New York, NY and additional mailing offices. Subscription prices are $370.00 per year for US individuals, $627.00 per year for US institutions, $180.00 per year for US students and residents, $455.00 per year for Canadian individuals, $793.00 per year for Canadian institutions, $510.00 for international individuals, $793.00 per year for international institutions and $250.00 per year for Canadian and foreign students/residents. To receive student/resident rate, orders must be accompanied by name of affiliated institution, date of term, and the signature of program/residency coordinator on institution letterhead. Orders will be billed at individual rate until proof of status is received. Foreign air speed delivery is included in all Clinics subscription prices. All prices are subject to change without notice. POSTMASTER: Send address changes to Surgical Clinics , Elsevier Health Sciences Division, Subscription Customer Service, 3251 Riverport Lane, Maryland Heights, MO 63043. Customer Service (orders, claims, online, change of address): Telephone: [phone] (U.S. and Canada); 314-447-8871 (outside U.S. and Canada). Fax: [phone]. E-mail: [e-mail] (for print support); [e-mail] (for online support) .
Reprints . For copies of 100 or more, of articles in this publication, please contact the Commercial Reprints Department, Elsevier Inc., 360 Park Avenue South, New York, New York 10010-1710. Tel. [phone], Fax: [phone], E-mail: [e-mail] .
The Surgical Clinics of North America is also published in Spanish by McGraw-Hill Interamericana Editores S.A., P.O. Box 5-237 06500 Mexico D.F. Mexico; and in Portuguese by Interlivros Edicoes Ltda., Rua Comandante Coelho 1085, CEP 21250, Rio de Janeiro, Brazil; and in Greek by Paschalidis Medical Publications, Athens Greece.
The Surgical Clinics of North America is covered in MEDLINE/PubMed (Index Medicus), EMBASE/Excerpta Medica, Current Contents / Clinical Medicine, Current Contents / Life Sciences, Science Citation Index , and ISI/BIOMED .