Cell/Tissue Injury and Cytoprotection/Organoprotection in the Gastrointestinal Tract

Description

In recent years, there have been significant advances both in understanding the mechanisms involved in gastrointestinal mucosal injury and protection, as well as in the development of successful strategies for prevention and treatment of gastrointestinal injury. Nevertheless, many people worldwide still suffer from gastrointestinal damage.This book contains contributions by an international panel of researchers in the form of up-to-date reviews on the mechanisms of gastrointestinal injury and protection. These are complemented by papers discussing how these new findings about cell/tissue injury and cytoprotection/organoprotection can be applied to the prevention and treatment of tissue damage in the gastrointestinal tract. Moreover, the publication includes a special chapter on Andre Robert, who has discovered the phenomenon of gastric cytoprotection.This publication will be of great interest for both basic and clinical researchers in gastroenterology and pharmacology, reviewing the advances made so far and pointing towards future developments.

Informations

• Publié par: S. Karger AG
• Date de parution: 22 juin 2012
• Nombre de lectures: 0
• EAN13: 9783318021844
• Langue: English
• Poids de l'ouvrage: 3 Mo

Extrait

Cell/Tissue Injury and Cytoprotection/Organoprotection in the Gastrointestinal Tract: Mechanisms, Prevention and Treatment
Frontiers of Gastrointestinal Research
Vol. 30
Series Editor
Choitsu Sakamoto     Tokyo
 
Cell/Tissue Injury and Cytoprotection/ Organoprotection in the Gastrointestinal Tract
Mechanisms, Prevention and Treatment
Volume Editors
Ludmila P. Filaretova    St. Petersburg
Koji Takeuchi    Kyoto
49 figures and 10 tables, 2012
Frontiers of Gastrointestinal Research
_________________________
_________________________
Prof. Ludmila Filaretova Laboratory of Experimental Endocrinology Pavlov Institute of Physiology Russian Academy of Sciences St. Petersburg 199034 Russia
Prof. Koji Takeuchi Division of Pathological Sciences Department of Pharmacology and Experimental Therapeutics Kyoto Pharmaceutical University Misasagi Yamashina Kyoto 607-8414 Japan
Library of Congress Cataloging-in-Publication Data
International Symposium on Cell/Tissue Injury and Cytoprotection/Organoprotection: Focus on GI Tract (6th: 2011: Saint Petersburg, Russia)
Cell/tissue injury and cytoprotection/organoprotection in the gastrointestinal tract: mechanisms, prevention, and treatment / volume editors, Ludmila Filaretova, Koji Takeuchi.
p.; cm. – – (Frontiers of gastrointestinal research, ISSN 0302-0665; v. 30)
Papers published here were presented at the 6th International Symposium on Cell/Tissue Injury and Cytoprotection/Organoprotection: Focus on GI Tract, held in St. Petersburg, Russia on October 12-14, 2011.
Includes bibliographical references and indexes.
ISBN 978-3-318-02183-7 (hard cover: alk. paper) -- ISBN 978-3-318-02184-4 (e-ISBN)
I. Filaretova, L. P. (Liudmila Pavlovna) II. Takeuchi, K. (Koji) III. Title. IV. Series: Frontiers of gastrointestinal research ; v. 30. 0302-0665
[DNLM: 1. Gastrointestinal Diseases--physiopathology--Congresses. 2. Cytoprotection--physiology--Congresses. 3. Disease Models, Animal--Congresses. 4. Gastrointestinal Tract--cytology--Congresses. 5. Mucous Membrane--drug effects--Congresses. 6. Protective Agents--Congresses. W1 FR946E v.30 2012/WI 140]
362.19633– –dc23
2012017310
Bibliographic Indices. This publication is listed in bibliographic services, including Current Contents ® and Index Medicus.
Disclaimer. The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publisher and the editor(s). The appearance of advertisements in the book is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
Drug Dosage. The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any change in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
© Copyright 2012 by S. Karger AG, P.O. Box, CH-4009 Basel (Switzerland)
www.karger.com
Printed in Germany on acid-free and non-aging paper (ISO 9706) by Kraft Druck GmbH, Ettlingen
ISSN 0302-0665
e-ISSN 1622-3754
ISBN 978-3-318-02183-7
e-ISBN 978-3-318-02184-4
 
Contents
Preface
Filaretova, L.P. (St. Petersburg); Takeuchi, K. (Kyoto)
The‘Gastric Cytoprotection’Concept of Andre Robert and the Origins of a New Series of International Symposia
Szabo, S. (Long Beach, Calif./Irvine, Calif.);Tache, Y. (Los Angeles, Calif.); Tarnawski, A. (Long Beach, Calif./Irvine, Calif.)
Importance of Translational Research in GI Pharmacology: Lessons Learned from the Successes in History
Chen, D.; Zhao, C.-M. (Trondheim)
Acetic Acid Ulcer Model - State of the Art in 2012
Okabe, S.; Amagase, K.;Takeuchi, K. (Kyoto)
Roles of EP4 Receptors in Protective and Healing-Promoting Effects of Prostaglandin E 2 on NSAID-Induced Small Intestinal Damage
Takeuchi, K. (Kyoto)
Role of Food and Enterobacteria in the Formation and Prevention of Small Intestinal Damage Induced by NSAIDs
Satoh, H.;Takeuchi, K. (Kyoto)
Synergic Effect of NSAID and Gastric Acid on Superoxide-Anion Production in Stomach
Matsui, H.; Kaneko, T. (Tsukuba)
Development of NSAIDs with Lower Gastric Side Effect
Mizushima, T. (Tokyo)
NSAID-Mucosal Injury: Roles of Drug Chemistry in Pathogenesis
Rainsford, K.D. (Sheffield)
Animal Model for Evaluating Gastric Bleeding and Ulcerogenic Response Induced by Aspirin plus Clopidogrel
Izuhara, C.; Takayama, S.; Itayama, M.; Hoshin, N.; Yoshida, Y.; Takeuchi, K. (Kyoto)
Effects of Ibuprofen, and Some Analogues, on the Muscle Tone of Isolated Segments of the Common Digital Artery of the Fallow Deer (Dama dama)
Callingham, B.A.; Maini, A.; Masood, F.; Munnawwar, M.; Rhodes, C.; Milton, A.S. (Cambridge); Rainsford, K.D. (Sheffield)
Psychological Stress Induces Visceral Analgesic or Hyperalgesic Response in Rodents: A Role of Preconditions
Mulak, A. (Los Angeles, Calif./Wroclaw); Larauche, M.;Taché, Y. (Los Angeles, Calif.)
Neurobiology of Corticotropin-Releasing Factor in the Enteric Nervous System during Stress
Liu, S. (La Crosse, Wisc.); Wood, J.D. (Columbus, Ohio)
Corticotropin-Releasing Factor May Protect the Gastric Mucosa in Stress through Involvement of Glucocorticoids
Filaretova, L.P.; Bagaeva, T.R.; Morozova, O.Y.; Mayzina, M.A. (St. Petersburg)
Pathogenic Potential of Psychogenic Stress in Gastric Mucosal Injury
Ovsiannikov, V.I.; Berezina, T.P. (St. Petersburg)
Advances in Understanding Inflammation in Esophageal Disease
Hunt, R.H.; Yuan, Y. (Hamilton, Ont.)
Physiopathology of Esophageal Inflammation, Ulcerogenesis and Repair by Studying the Profile of Glycoconjugate
Zayachkivska, O. (Lviv)
Analysis of the Effect of Different Neuropeptides in Gastric Mucosal Defense Initiated Centrally
Gyires, K. (Budapest)
Sulforaphane Enhances Protection and Repair of Gastric Mucosa against Oxidative Stress via Nrf2-Dependent Mechanisms
Yanaka, A. (Hitachi)
Involvement of Renin-Angiotensin System and Vasoactive Angiotensin-(1-7) Metabolite of Angiotensin II in Gastric Mucosal Injury and Gastroprotection
Brzozowski, T.; Kwiecien, S.;Szlachcic, A.; Strzalka, M.; Drozdowicz, D.; Pajdo, R.;Szmyd, J.; Konturek, S.J.; Pawlik, W.W. (Cracow)
Effect of Pentadecapeptide BPC 157 on Gastrointestinal Tract
Sikiric, P.;Seiwerth, S.; Rucman, R.;Turkovic, B.; Rokotov, D.S.; Brcic, L.; Sever, M.; Klicek, R.; Radic, B.; Drmic, D.; Ilic, S.; Kolenc, D.; Suran, J.;Vrcic, H.; Sebecic, B. (Zagreb)
Pathobiology of Gastric Carcinoids and Adenocarcinomas in Rodent Models and Patients: Studies of Gastrocystoplasty, Gender-Related Factors and Autophagy
Vigen, R.A.; Chen, D.; Zhao, C.-M. (Trondheim)
Roles of the Hydrogen Sulfide/T-Type Calcium Channel System in Somatic and Visceral Pain Processing
Kawabata, A.; Matsunami, M. (Higashi-Osaka)
Age-Dependent Role of Vasopressin in Susceptibility of Gastric Mucosa to Indomethacin-Induced Injury
Zelena, D. (Budapest); Morozova, O.Y.; Filaretova, L.P. (St. Petersburg)
From Mucosal Energy Metabolism to Capsaicin - Strategies for Understanding Mucosal Protection
Szabó, I.L.; Czimmer, J.; Mózsik, G. (Pécs)
Author Index
Subject Index
 
Preface
Despite indubitable advances in understanding the mechanisms involved in gastrointestinal mucosal injury and protection as well as the development of successful strategies for prevention and treatment of the gastrointestinal injury, many people still suffer from the gastrointestinal damage over the world.
This volume of the Frontiers of Gastrointestinal Research series includes up-to-date reviews on the mechanisms of the gastrointestinal injury and protection. The papers published here were presented at the 6th International Symposium on Cell/ Tissue Injury and Cytoprotection/Organoprotection - Focus on GI Tract -, which was held in St. Petersburg, Russia on October 12-14, 2011.
The symposium was another in a successful series of symposia held since 1986. This symposia series is the product of international cooperation and interdisciplinary communication between basic science and clinical investigators who demonstrate that controversies and scientific disputes are best resolved by open communication and display of new data. Actually, the series grew out of disputes over the role of intracellular calcium and phospholipase activation (Farber vs. Orrenius) in cell injury, and of prostaglandins vs. antioxidant sulfhydryls in cytoprotection (Robert vs. Szabo). The first article of this book is devoted to