Corticosteroids, An Issue of Rheumatic Disease Clinics of North America

Marcy B. Bolster

Description

Corticosteroids represent the most important and frequently used class of anti-inflammatory and immunosuppressant agents in the management of many rheumatological conditions. Included in this issue will be articles on the following topics: Glucocorticoid use in intra-articular and soft tissue injections, corticosteroids and osteoporosis, corticosteroids in lupus, ANCA associated vasculitis, and many more!

Sujets

• Médecine
• Médecine Générale
• Medical
• Rheumatology

Informations

• Publié par: Elsevier
• Date de parution: 19 janvier 2016
• Nombre de lectures: 0
• EAN13: 9780323417136
• Langue: English
• Poids de l'ouvrage: 3 Mo

Extrait

Corticosteroids
Rheumatic Disease Clinics of North America
Editor
Marcy B. Bolster, MD
Rheumatology Fellowship Training Program, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts
Consulting Editor
Michael H. Weisman

Clinics Review Articles

www.rheumatic.theclinics.com

February 2016 Volume 42 Number 1
Table of Contents
Cover image
Title page
Copyright
Contributors
Consulting Editor
Editor
Authors
Forthcoming Issues
Forthcoming Issues
Recent Issues
Foreword. Corticosteroids
Preface. Corticosteroids: Friends and Foes
The History of Cortisone Discovery and Development
Key points
Introduction
Philip Showalter Hench
Edward Charles Kendall
World War II
Mrs G
The story breaks
The Nobel Prize
Aftermath
The EMPIRE strikes back
Epilogue
The legacy of corticosteroids
References
Corticosteroids: Mechanisms of Action in Health and Disease
Key points
Introduction
Glucocorticoid synthesis, secretion, and bioavailability
Glucocorticoid receptor
Mechanisms of glucocorticoid action
Glucocorticoid receptor heterogeneity
Summary and future considerations
References
Glucocorticoids and Rheumatoid Arthritis
Key points
Introduction
Clinical applications in rheumatoid arthritis
Dosing in rheumatoid arthritis
Administration in rheumatoid arthritis
Side effects
Drug-drug interactions
Future considerations
Summary
References
Corticosteroids in Lupus
Key points
Introduction
Clinical applications
Dosing
Administration
Side effects
Drug-drug interactions
Practical treatment considerations
Future considerations/summary
References
Corticosteroids in Lupus Nephritis and Central Nervous System Lupus
Key points
Introduction
Epidemiology of lupus nephritis
Evaluation of lupus nephritis
Treatment goals for lupus nephritis
Proliferative lupus nephritis induction therapy
Proliferative lupus nephritis maintenance therapy
Challenging current corticosteroid practices
Tapering of corticosteroids
Epidemiology of central nervous system lupus
Evaluation of central nervous system lupus
Common central nervous system features in patients with lupus
Features of less frequent central nervous system lupus events
Treatment strategies for central nervous system lupus
Immunosuppression for central nervous system lupus refractory to corticosteroids
Adverse effects of corticosteroids
Summary
References
Glucocorticoids for Management of Polymyalgia Rheumatica and Giant Cell Arteritis
Key points
Introduction
Clinical features
Management
Glucocorticoids for treatment of polymyalgia rheumatica and giant cell arteritis
Mechanisms of glucocorticoid actions
Why does clinical efficacy of glucocorticoid therapy vary among different patients?
Adverse effects of glucocorticoids
Clinical aspects of therapy with glucocorticoids in polymyalgia rheumatica and giant cell arteritis
Nonsteroidal antiinflammatory drugs and analgesics in polymyalgia rheumatica and giant cell arteritis
Glucocorticoid-sparing agents in polymyalgia rheumatica and giant cell arteritis
Aspirin use in giant cell arteritis
Management of glucocorticoid-related complications in polymyalgia rheumatica and giant cell arteritis
Summary
References
Corticosteroids in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis
Key points
Introduction
Remission induction therapy
Maintenance therapy
Treatment of relapses
Local glucocorticoids
Future considerations
Summary
References
Corticosteroids in Myositis and Scleroderma
Key points
Idiopathic inflammatory myopathies
Polymyositis
Dermatomyositis
Inclusion body myositis
Necrotizing myopathies
Scleroderma: localized scleroderma (morphea) and systemic sclerosis
Localized scleroderma (morphea)
Systemic sclerosis
Summary
References
Corticosteroids in Sarcoidosis
Key points
Introduction
Indications to treat sarcoidosis
General approach to the treatment of sarcoidosis with corticosteroids
Corticosteroid therapy for specific forms of sarcoidosis
Summary
References
Corticosteroids for Pain of Spinal Origin: Epidural and Intraarticular Administration
Key points
Introduction
Background
Therapeutic rationale
Clinical indications
Anatomic targets for corticosteroid injection
Epidural steroid injection
Local injection for chronic low back pain syndromes attributed to the lumbar facet joints
Sacroiliac joint injection
Side effects of the steroids
Oral steroids
References
Infection Risk and Safety of Corticosteroid Use
Key points
Introduction
Infection in rheumatic diseases and corticosteroids
Randomized controlled trials
Observational studies
Opportunistic infections
Pneumocystis jiroveci Pneumonia
Vaccination and other prevention strategies
Summary
References
Glucocorticoid-induced Osteoporosis
Key points
Introduction
Glucocorticoid effects on bone
Epidemiology
Diagnosis/identifying patients at risk
Prevention and treatment
Summary
Acknowledgments
References
Index
Copyright
ELSEVIER
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RHEUMATIC DISEASE CLINICS OF NORTH AMERICA Volume 42, Number 1
February 2016 ISSN 0889-857X, ISBN 13: 978-0-323-41712-9
Editor: Jennifer Flynn-Briggs
Developmental Editor: Casey Jackson
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