Cosmetic Photodynamic Therapy

Description

Photodynamic Therapy (PDT) has become an important treatment modality in medical practice. New and exciting applications continue to emerge and the future of PDT looks brighter and brighter. Dermatologists and other health professionals around the world rely on its therapeutic effect for the treatment of actinic keratoses, non-melanoma skin cancers, acne vulgaris, and various other dermatologic conditions. In this comprehensive yet concise book, world-renowned experts showcase all of the common, everyday uses of PDT in dermatologic offices. They also examine how this beneficial therapy can be utilized to its full capacity. The considerable knowledge presented here renders this publication an indispensable resource for all dermatologists and health professionals who offer their patients this effective, noninvasive procedure.

Informations

• Publié par: S. Karger AG
• Date de parution: 02 janvier 2016
• Nombre de lectures: 1
• EAN13: 9783318025576
• Langue: English
• Poids de l'ouvrage: 3 Mo

Extrait

Cosmetic Photodynamic Therapy
Aesthetic Dermatology
Vol. 3
Series Editor
David J. Goldberg New York, N.Y.
Cosmetic Photodynamic Therapy
Volume Editor
Michael H. Gold Nashville, Tenn.
34 figures, 26 in color, and 10 tables, 2016
_______________________ Michael H. Gold, MD Medical Director Gold Skin Care Center Tennessee Clinical Research Center Nashville, Tenn., USA
Library of Congress Cataloging-in-Publication Data
Names: Gold, Michael H., editor.
Title: Cosmetic photodynamic therapy / volume editor, Michael H. Gold.
Other titles: Aesthetic dermatology (Series) ; v. 3. 2235-8609
Description: Basel ; New York : Karger, 2016. | Series: Aesthetic dermatology, ISSN 2235-8609 ; vol. 3 | Includes bibliographical references and indexes.
Identifiers: LCCN 2015045339 | ISBN 9783318025569 (hard cover : alk. paper) | ISBN 9783318025576 (e-ISBN)
Subjects: | MESH: Photochemotherapy--methods. | Cosmetic Techniques. | Precancerous Conditions--drug therapy. | Skin Diseases--drug therapy.
Classification: LCC RD119 | NLM WB 480 | DDC 617.9/52--dc23 LC record available at
http://lccn.loc.gov/2015045339

Bibliographic Indices. This publication is listed in bibliographic services, including Current Contents ® .
Disclaimer. The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publisher and the editor(s). The appearance of advertisements in the book is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
Drug Dosage. The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any change in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
© Copyright 2016 by S. Karger AG, P.O. Box, CH-4009 Basel (Switzerland)
www.karger.com
Printed in Germany on acid-free and non-aging paper (ISO 9706) by Kraft Druck GmbH, Ettlingen
ISSN 2235-8609
e-ISSN 2235-8595
ISBN 978-3-318-02556-9
e-ISBN 978-3-318-02557-6
Contents
Preface
Gold, M.H. (Nashville, Tenn.)
A Historical Look at Photodynamic Therapy
Gold, M.H. (Nashville, Tenn.)
Photodynamic Therapy in Treating Actinic Keratosis and Photorejuvenation
Peterson, J.D. (Katy,Tex.); Goldman, M.P. (San Diego, Calif.)
Topical Methyl Aminolevulinate-Photodynamic Therapy for the Treatment of Actinic Keratoses and Photorejuvenation
Foley, P. (Fitzroy,Vic./Carlton,Vic.)
Photodynamic Therapy- Novel Cosmetic Approaches
Munavalli, G.S. (Charlotte, N.C./Winston-Salem, N.C.); Clementoni, M.T. (Milan); Roscher, M.B. (Durban)
Photodynamic Therapy for Acne Vulgaris and Sebaceous Gland Hyperplasia
Taub, A.F. (Lincolnshire, Ill/Chicago, Ill.); Schieber, A.C. (Lincolnshire, Ill.)
Chemoprevention Using Photodynamic Therapy with Aminolevulinic Acid
Martin, G. (Kihei, Hawaii)
How I Use Photodynamic Therapy with 5-Aminolevulinic Acid in My Clinical Practice
Gilbert, D.J. (Newport Beach, Calif.)
Author Index
Subject Index
Preface
Photodynamic therapy (PDT) has become a very acceptable and useful therapy for dermatologists and others all around the world. New and exciting ways to utilize PDT continue to emerge and the future for PDT looks brighter and brighter. What began as two pathways for PDT use in dermatology, with the United States working predominantly with aminolevulinic acid (ALA) as the photosensitizer and with blue light and lasers, while the European model has been a study in the use of methyl ester of ALA with red light. The paths have now converged as far as light sources are concerned, and people have begun using the light sources interchangeably to fit the patient's needs and the circumstances of the treatment. This latest textbook on PDT brings together some of the greatest minds in the field and in the study of PDT, from all corners of the globe. PDT is truly global, and I hope that with this volume, one learns that there are wonderful therapeutic options that exist now when we use PDT, and the cosmetic outcomes, which are achieved with its use, continue to elevate PDT in every practitioner's therapeutic and cosmetic armamentarium.
As I have noted in other textbooks that I have had the privilege to edit, I am truly one of the fortunate dermatologists who has surpassed every dream and inspiration that I ever had when I began my career over 25 years ago. I want to thank Northwestern University for allowing me to be a dermatology resident under the leadership of Dr. Henry Roenigk. He pushed and guided us to be the best we can be and he, along with Drs. William Caro, June Robinson, Jerome Garden, and our beloved Ruth Frankel, inspired us and commanded us to work hard, be compassionate, and strive to give the best patient care. My fellow residents, who made me who I am, also are some of my best friends today. Thanks go to Drs. Amy Taub, Morgan Magid, David Piscasia, Dan Kaufman, Andrew Lazar, Richard Rubenstein, Neil Goldberg, and Kevin Pinski. These incredible practitioners, friends, and colleagues have been with me then and now, and I cannot thank them enough for their friendship, their encouragement, and their drive to make me a better dermatologist.
In one's career, one is fortunate to meet and work with a few really special people. I am extremely fortunate to have worked with some of the most talented and incredible dermatologists that, again, have shaped my career and have made me a better person and a better dermatologist. Thanks go to Drs. David Goldberg, Mitch Goldman, Mark Nestor, and George Martin. When it comes to PDT and what little I have contributed to the field, I must remember the late Dr. Geoffrey Shulman, the one who first sparked my interest in the field, as well as Dr. Stuart Marcus and Paul Sowyrda. Each one of these people has been a key part in my growth with PDT and dermatology.
One cannot end without thanking those who really deserve the credit for allowing me to be who I am and to do what I do. My wife Cindee, and my children Ilissa and Benjamin, along with my golden doodles Shana and Boychik, have let me be me, have let me go to places I have never dreamt I would visit, and allow me to be the best I can be. I love them all very much. And to my parents, Jerry and Anne, I am grateful for all of your teachings and guidance over my lifetime, and to have incredible parents like you.
Michael H. Gold, Nashville, Tenn.
Gold MH (ed): Cosmetic Photodynamic Therapy. Aesthet Dermatol. Basel, Karger, 2016, vol 3, pp 1-7 DOI: 10.1159/000439327
______________________
A Historical Look at Photodynamic Therapy
Michael H. Gold
Gold Skin Care Center, Tennessee Clinical Research Center, and Division of Dermatology, Department of Medicine, Vanderbilt University School of Nursing, and School of Medicine, Meharry Medical College, Nashville, Tenn., USA
______________________
Abstract
Many dermatologists who utilize photodynamic therapy (PDT) in their everyday clinical practices assume that PDT is a fairly new therapeutic modality. In fact, and surprising to many, PDT has been available in medicine since the beginning of the 20th century. In this review, we will trace some of the major roots of PDT and how it ended up in the capable hands of dermatologists, many of whom utilize the treatment on a daily basis for the well-being of their patients with a variety of skin concerns.
© 2016 S. Karger AG, Basel
The beginnings of photodynamic therapy (PDT) history can be traced to the year 1900, when Raab [ 1 ] first described an experiment that was conducted with cells from Paramecium caudatum . He noted that the paramecium cells were not affected in any way when they were exposed to either acridine orange or a light source alone. But he noted that if the paramecium cells were exposed to the acridine orange and the light source at the same time, the same cells died within 2 h of this exposure. This was the first report of how PDT would come to be - the use of a photosensitizer, in this case acridine orange, and a light source to cause an effect on a cell, in this case, cell death.
Several years later, in 1904, von Tappeiner and Jodblauer [ 2 ] termed the expression photodynamic effect as they described their experiments in which an oxygen-consuming reaction in protozoa was noted after aniline dyes were applied to the protozoa with fluorescence. The following year, in 1905, Jesionek and von Tappeiner [ 3 ] reported on their experiences with a topical 5% eosin as a photosensitizer in their experiments on PDT. Topical 5% eosin was used successfully as a photosensitizer with an artificial light source to successfully treat a variety of dermatologic skin conditi