Current Concepts in Uveal Melanoma

Description

Uveal melanoma is an aggressive form of cancer that can involve the iris, the ciliary body, and/or the choroid, which is the main location of this tumor. Patients often wish to be informed about treatment choices and the results of different approaches. Important current clinical questions are whether a biopsy should be taken of choroidal melanomas, what should be done with this biopsy, and whether high-risk patients should be screened regularly.This volume describes the clinical characteristics of uveal melanoma along with the different current techniques available for treatment, such as radioactive plaque treatment, proton beam therapy, and local tumor resection. Furthermore, techniques for taking biopsies and characterizing biopsy material are demonstrated. Future therapies such as anti-VEGF treatment and options for the treatment of metastases are also discussed. Residents with an interest in ocular oncology, ophthalmologists or physicians dealing with uveal melanoma, as well as patients wishing to know more about this malignancy will find a topical update on uveal melanoma in this publication.

Informations

• Publié par: S. Karger AG
• Date de parution: 24 octobre 2011
• Nombre de lectures: 0
• EAN13: 9783805597913
• Langue: English
• Poids de l'ouvrage: 1 Mo

Extrait

Current Concepts in Uveal Melanoma
Developments in Ophthalmology
Vol.49
Series Editor
F. Bandello     Milan
 
Current Concepts in Uveal Melanoma
Volume Editors
Martine J. Jager     Leiden
Laurence Desjardins     Paris
Tero Kivelä     Helsinki
Bertil E. Damato     Liverpool
37 figures, 23 in color, and 12 tables, 2012
_________________________
__________________________
Martine J. Jager Department of Ophthalmology Leiden University Medical Centre (LUMC) PO Box 9600 NL-2300 RC Leiden (The Netherlands)
Laurence Desjardins Department of Ophthalmology Institut Curie 26, rued'Ulm FR-75005 Paris (France)
_________________________
__________________________
Tero Kivelä Department of Ophthalmology Helsinki University Central Hospital Haartmaninkatu 4 C, PL 220 FI-00029 HUS, Helsinki (Finland)
Bertil E. Damato Ocular Oncology Service Royal Liverpool University Hospital Prescot Street Liverpool L7 8XP (UK)
This book was supported by
Library of Congress Cataloging-in-Publication Data
Current concepts in uveal melanoma / volume editors, Martine J. Jager… [etal.].
p.; cm. –– (Developments in ophthalmology, ISSN 0250-3751 ; v. 49)
Includes bibliographical references and index.
ISBN 978-3-8055-9790-6 (hard cover: alk. paper) –– ISBN 978-3-8055-9791-3 (e-ISBN)
I. Jager, Martine. II. Series: Developments in ophthalmology; v. 49. 0250-3751
[DNLM:1. Melanoma-therapy. 2. Uveal Neoplasms-therapy. 3. Melanoma-diagnosis. 4. Uveal Neoplasms-diagnosis. W1 DE998NG v.49 2012/WW 240]
616.99'477-dc23
2011033492
Bibliographic Indices. This publication is listed in bibliographic services, including Current Contents® and Index Medicus.
Disclaimer. The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publisher and the editor(s). The appearance of advertisements in the book is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
Drug Dosage. The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any change in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
© Copyright 2012 by S. Karger AG, P.O. Box, CH-4009 Basel (Switzerland)
www.karger.com
Printed in Switzerland on acid-free paper by Reinhardt Druck, Basel
ISSN 0250-3751
ISBN 978-3-8055-9790-6
e-ISBN 978-3-8055-9791-3
 
Contents
List of Contributors
Preface
Jager, M.J. (Leiden); Desjardins, L. (Paris); Kivelä, T. (Helsinki); Damato, B.E. (Liverpool)
Diagnosis of Uveal Melanoma
Kivelä, T. (Helsinki)
Treatment Selection for Uveal Melanoma
Damato, B.E. (Liverpool)
Ruthenium-106 Brachytherapy
Pe'er, J. (Jerusalem)
Treatment of Uveal Melanoma by Accelerated Proton Beam
Desjardins, L.; Lumbroso-Le Rouic, L.; Levy-Gabriel, C.; Cassoux, N.; Dendale, R.; Mazal, A.; Delacroix, S.; Sastre, X.; Plancher, C.; Asselain, B. (Paris)
Stereotactic Photon Beam Irradiation of Uveal Melanoma
Zehetmayer, M. (Vienna)
Local Resection of Uveal Melanoma
Damato, B.E. (Liverpool)
Biopsies in Uveal Melanoma
Midena, E. (Padova/Rome); Parrozzani, R. (Rome)
Analysis of Intraocular Biopsies
Coupland, S.E. (Liverpool)
Anti-AngiogenicTherapy in Uveal Melanoma
el Filali, M.; van der Velden, P.A.; Luyten, G.P.M.; Jager, M.J. (Leiden)
Immunotherapy of Uveal Melanoma
Bosch, J.J. (Erlangen)
Genetic Determinants of Uveal Melanoma
Couturier, J. (Paris); Saule, S. (Orsay)
Therapeutic Options in Metastatic Uveal Melanoma
Mariani, P.;Servois, V.; Piperno-Neumann, S. (Paris)
Subject Index
 
List of Contributors
Bernard Asselain
Department of Biostatistics
26, rue d'Ulm
FR-75005 Paris (France)
E- Mail [e-mail]
Jacobus J. Bosch
Department of Internal Medicine 5,
Hematology and Medical Oncology
University Hospital Erlangen
DE-91054 Erlangen (Germany)
E- Mail [e-mail]
Nathalie Cassoux
Department of Ophthalmology
Institut Curie
26, rue d'Ulm
FR-75005 Paris (France)
E- Mail [e-mail]
Sarah E. Coupland
Department of Cellular and Molecular
Pathology
University of Liverpool, 5th Floor Duncan
Building
Daulby Street, Liverpool L69 3GA (UK)
E- Mail [e-mail]
Jérôme Couturier
Department of Genetics
Institut Curie - Hôpital
26, rue d'Ulm
FR-75248 Paris (France)
E- Mail [e-mail]
Bertil E. Damato
Ocular Oncology Service
Royal Liverpool University Hospital
Prescot Street
Liverpool L7 8XP (UK)
E- Mail [e-mail]
Sabine Delacroix
Department of Biophysics
Institut Curie
26, rue d'Ulm
FR-75005 Paris (France)
E- Mail [e-mail]
Remi Dendale
Department of Radiotherapy
Institut Curie
26, rue d'Ulm
FR-75005 Paris (France)
E- Mail [e-mail]
Laurence Desjardins
Department of Ophthalmology
Institut Curie
26, rue d'Ulm
FR-75005 Paris (France)
E- Mail [e-mail]
Mariam el Filali
Department of Ophthalmology
Leiden University Medical Centre (LUMC)
PO Box 9600
NL-2300 RC Leiden (The Netherlands)
E- Mail [e-mail]
Martine J. Jager
Department of Ophthalmology
Leiden University Medical Centre (LUMC)
PO Box 9600
NL-2300 RC Leiden (The Netherlands)
E- Mail [e-mail]
Tero Kivelä
Department of Ophthalmology
Helsinki University Central Hospital
Haartmaninkatu 4 C, PL 220
FI-00029 HUS, Helsinki (Finland)
E- Mail [e-mail]
Christine Levy-Gabriel
Department of Ophthalmology
Institut Curie
26, rue d'Ulm
FR-75005 Paris (France)
E- Mail [e-mail]
Livia Lumbroso-Le Rouic
Department of Ophthalmology
Institut Curie
26, rue d'Ulm
FR-75005 Paris (France)
E- Mail [e-mail]
Gregorius P.M. Luyten
Department of Ophthalmology
Leiden University Medical Centre (LUMC)
PO Box 9600
NL-2300 RC Leiden (The Netherlands)
E- Mail [e-mail]
Pascale Mariani
Department of Surgery
Institut Curie
26, rue d'Ulm
FR-75248 Paris (France)
E- Mail [e-mail]
Alexandro Mazal
Department of Biophysics
Institut Curie
26, rue d'Ulm
FR-75005 Paris (France)
E- Mail [e-mail]
Edoardo Midena
Department of Ophthalmology
University of Padova
Via Giustiniani 2
IT-35128 Padova (Italy)
E- Mail [e-mail]
Raffaele Parrozzani
Fondazione GB Bietti per I'Oftalmologia
IRCCS
Via Livenza 3
IT-00198 Rome (Italy)
E- Mail [e-mail]
Jacob Pe'er
Department of Ophthalmology
Hadassah-Hebrew University Medical Center
PO Box 12000
Jerusalem 91120 (Israel)
E- Mail [e-mail]
Sophie Piperno-Neumann
Department of Medical Oncology
Institut Curie
26, rue d'Ulm
FR-75248 Paris (France)
E- Mail [e-mail]
Corine Plancher
Department of Biostatistics
26, rue d'Ulm
FR-75005 Paris (France)
E- Mail [e-mail]
Simon Saule
Institut Curie
Centre Universitaire
Bâtiment 110
FR-91405 Orsay (France)
E- Mail [e-mail]
Xavier Sastre
Department of Pathology
Institut Curie
26, rue d'Ulm
FR-75005 Paris (France)
E- Mail [e-mail]
Vincent Servois
Department of Radiology
Institut Curie
26, rue d'Ulm
FR-75248 Paris (France)
E- Mail [e-mail]
Pieter A. van der Velden
Department of Ophthalmology
Leiden University Medical Centre (LUMC)
PO Box 9600
NL-2300 RC Leiden (The Netherlands)
E- Mail [e-mail]
Martin Zehetmayer
Department of Ophthalmology and Optometry
Medical University of Vienna
Waehringe