Diabetes in Cardiovascular Disease: A Companion to Braunwald's Heart Disease E-Book

Nikolaus Marx, Darren K Mcguire

Description

Diabetes in Cardiovascular Disease is a current, expert resource focusing on the complex challenges of providing cardiovascular care to patients with diabetes. Designed as a companion to Braunwald’s Heart Disease, this interdisciplinary medical reference book bridges the gap between the cardiology and endocrinology communities of scientists and care providers, and highlights the emerging scientific and clinical topics that are relevant for cardiologists, diabetologists/endocrinologists, and the extended diabetes care team.

• Access essential coverage of basic and clinical sciences, complemented by an expanded focus on epidemiology, behavioral sciences, health policy, and disparities in health care.
• Take advantage of a format that follows that of the well-known and internationally recognized Braunwald’s Heart Disease.
• Review the best available clinical data and pragmatic recommendations for the prevention and management of cardiovascular complications of diabetes; national/societal intervention strategies to curb the growing prevalence of diabetes; and the current pathophysiological understanding of cardiovascular comorbidities in patients with diabetes.
• Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability.

Sujets

• Médecine
• Spécialités médicales
• Médecine Générale
• Medical
• Cardiology

Informations

• Publié par: Saunders
• Date de parution: 10 octobre 2014
• Nombre de lectures: 2
• EAN13: 9780323315661
• Langue: English
• Poids de l'ouvrage: 3 Mo

Extrait

Diabetes in Cardiovascular Disease
A Companion to Braunwald’s Heart Disease
First Edition
Darren K. McGuire, MD, MHSc, FAHA, FACC
Professor of Internal Medicine, Dallas Heart Ball Chair for Research on Heart Disease in Women
Director, Parkland Hospital and Health System Cardiology Clinics, University of Texas Southwestern Medical Center, Dallas, Texas
Nikolaus Marx, MD, FAHA
Professor of Medicine/Cardiology, Head of Department of Internal Medicine I, University Hospital Aachen, Aachen, Germany
Table of Contents
Cover image
Title page
Copyright
Dedication
Contributors
Foreword
Preface
Acknowledgments
Part I: Diabetes Mellitus
1. Definition and Epidemiology of Type 2 Diabetes Mellitus
Type 2 Diabetes—Definitions and Outcomes
Global Burden of Diabetes
Causal Underpinnings of Diabetes
The Future of Diabetes Research
Summary
2. Insulin Resistance: Pathophysiology, Molecular Mechanisms, Genetic Insights
Genetic Factors
Insulin Resistance
Glucose Transport
The Role of the Adipocyte and Obesity in Type 2 Diabetes
Tissue- and Organ-Specific Contribution to Insulin Resistance
Beta Cell Dysfunction in Type 2 Diabetes
Summary
3. Type 1 Diabetes: Pathophysiology, Molecular Mechanisms, Genetic Insights
Pathogenesis
Autoimmunity
Etiology
SUMMARY
4. The Metabolic Syndrome: Prevalence and Controversies in Clinical Context
Association between Metabolic Syndrome and Cardiovascular Disease in the Population
Associations between Metabolic Syndrome and Intermediate Markers of Cardiovascular Disease
Cardiovascular Diseases and Metabolic Syndrome in Patients with Abnormal Glucose Tolerance
Common Soil for Metabolic Syndrome and Cardiovascular Disease?
Metabolic Syndrome as Guide for Patient-Centered Treatment
5. Lifestyle Interventions for the Prevention of Type 2 Diabetes Mellitus
The Global Epidemic of Type 2 Diabetes: An Overview
Evidence for Sustainable Type 2 Diabetes Prevention
The Elements of Type 2 Diabetes Prevention
Recommendations for Type 2 Diabetes Prevention Practice
Moving Diabetes Prevention into Practice
Summary
Acknowledgments
6. Pharmacologic and Surgical Interventions That Prevent or Worsen Type 2 Diabetes
Cardiovascular Pharmacologic Treatment that Influences Glucose Metabolism and the Development of Diabetes
Noncardiovascular Pharmacologic Treatment that Influences Glucose Metabolism and the Development of Diabetes
Invasive Treatment to Prevent or Reverse Diabetes
Summary
Part II: Diabetes and Atherosclerosis
7. Epidemiology of Coronary and Peripheral Atherosclerosis in Diabetes
Prevalence of Impaired Glucose Metabolism in Patients with Manifest Atherosclerosis
Diabetes Mellitus and Subclinical Atherosclerosis
Clinical Manifestations of Atherosclerosis in Prediabetes, Metabolic Syndrome, and Type 2 Diabetes
Short-Term and Long-Term Prognosis after Acute Myocardial Infarction in Patients with Pathologic Glucose Metabolism and after Coronary Interventions or with Heart Failure
Peripheral Arterial Disease and Diabetes
Diabetes and Coronary Heart Disease in Women
Diabetes and Atherosclerotic Complications: Geographic and Ethnic Differences
8. Pathology of Diabetic Atherosclerosis: Composition, Characteristics, and Distribution
Plaque Morphology and Inflammation in Diabetic Atherosclerosis
Mechanisms of Accelerated Atherosclerosis in Diabetes
Summary
9. Vascular Biology of Atherosclerosis in Patients with Diabetes: Hyperglycemia, Insulin Resistance, and Hyperinsulinemia
Diabetes and Accelerated Atherosclerosis
Insulin Resistance, Hyperinsulinemia, and Accelerated Atherosclerosis
Summary
10. Vascular Biology of Atherosclerosis in Patients with Diabetes: Dyslipidemia, Hypercoagulability, Endothelial Dysfunction, and Inflammation
Overview
Diabetic Dyslipidemia
Diabetes: A Prothrombotic State
Endothelial Function and Dysfunction in Diabetes
Inflammation: a Unifying Hypothesis of Diabetes and Atherosclerosis?
SUMMARY
11. Type 1 Diabetes and Associated Cardiovascular Risk and Disease
History
Magnitude of the Clinical Problem of Cardiovascular Disease in Type 1 Diabetes
Cardiovascular Disease Risk Factors in Type 1 Diabetes
Summary
Part III: Management of Coronary Heart Disease Risk and Disease in Patients with Diabetes
12. Effect of Lifestyle Interventions on Coronary Heart Disease Risk in Patients with Diabetes
Weight Management and Energy Balance
Exercise and Physical Activity in the Prevention and Treatment of Type 2 Diabetes Mellitus
Physical Activity, Exercise Programming, and Prescription
Psychosocial Interventions to Support Lifestyle Change
SUMMARY
13. Effect of Glucose Management on Coronary Heart Disease Risk in Patients with Diabetes
Changing Epidemiology of Diabetes and Coronary Heart Disease
Epidemiologic Relationship of Glucose with Coronary Heart Disease
Trials of Glucose-Lowering Interventions
Trials of GLUCOSE-LOWERING Interventions in Prediabetes and Early Diabetes
The “How” of Glucose Lowering: the Evidence for Specific Medications and Medication Classes
Risks Associated with Antihyperglycemic Medications
Implications for Clinical Practice
14. Effect of Blood Pressure Management on Coronary Heart Disease Risk in Patients with Type 2 Diabetes
Epidemiologic Associations Between Blood Pressure and Coronary Heart Disease in People with Type 2 Diabetes Mellitus
Efficacy of Lifestyle Interventions on Blood Pressure Levels and Coronary Heart Disease Risk in Patients with Type 2 Diabetes Mellitus
Efficacy and Safety of Blood Pressure–Lowering Drugs on Coronary Heart Disease in Patients with Type 2 Diabetes Mellitus
Efficacy and Safety of Renal Sympathetic Denervation
SUMMARY
15. Effect of Lipid Management on Coronary Heart Disease Risk in Patients with Diabetes
Overview
Lipid Management Strategies to Reduce Cardiovascular Risk
Clinical Practice Guidelines for Lipid-lowering Therapies
Summary
16. Effect of Antiplatelet Therapy on Coronary Heart Disease Risk in Patients with Diabetes Mellitus
Aspirin
P2Y12 Receptor Antagonists
Other Antiplatelet Medications
Protease-Activated Receptor 1 Antagonists
Future Directions
17. Role of Percutaneous Coronary Intervention in Patients with Diabetes
Specific Characteristics of Diabetes-Associated Atherothrombosis
Methodologic Considerations Related to Percutaneous Coronary Intervention Trials in Diabetes
Conservative Strategy
Percutaneous Coronary Intervention
Adjunctive Pharmacologic Treatment
Future Strategies to Improve Percutaneous Coronary Intervention Results
Summary
18. Role of Coronary Artery Bypass Surgery in Diabetes and Perioperative Glucose Management
Coronary Artery Bypass Graft Surgery in Patients with Diabetes
Revascularization Strategies for Patients with Diabetes
Hyperglycemia in Patients with Diabetes Undergoing Coronary Artery Bypass Graft Surgery
Part IV: Epidemiology and Management of Acute Coronary Syndromes in Patients with Diabetes
19. Epidemiology of Acute Coronary Syndromes in Patients with Diabetes
Global Burden of Cardiovascular Disease and Diabetes
Diabetes in Randomized Controlled Trials and Registry Studies of Acute Coronary Syndromes
Undiagnosed Diabetes in Patients With Cardiovascular Disease and Acute Coronary Syndrome Events
Summary
20. Hyperglycemia and Acute Coronary Syndromes: Association with Outcomes and Management
Definition of Hyperglycemia During Acute Coronary Syndrome
Prevalence of Elevated Glucose Levels in Acute Coronary Syndrome
The Relationship Between Glucose Levels and Mortality in Acute Coronary Syndrome
Dynamic Changes in Glucose Levels During Acute Coronary Syndrome and Mortality
Clinical Trials of Glucose Control in Patients with Acute Coronary Syndrome
The Relationship Between Glucose Variability and Patient Outcomes During Acute Coronary Syndrome
The Prognostic Importance of Hypoglycemia in Patients with Acute Coronary Syndrome
Current Patterns of Glucose Control in Acute Coronary Syndrome
Summary and Recommendations
21. Antiplatelet and Antithrombotic Therapy in Diabetic Patients with Acute Coronary Syndrome
Platelet Aggregation
Platelet Inhibition
Coagulation Inhibition
Summary
22. Role of Primary Invasive Strategy and Revascularization in Diabetic Patients with Acute Coronary Syndromes
Diabetes Mellitus as a Major Risk Factor in Acute Coronary Syndromes
Benefits of a Primary Invasive Strategy
Timing of Intervention
Revascularization Strategy
Procedural Aspects of Percutaneous Coronary Intervention and Coronary Artery Bypass Grafting
Summary
Part V: Heart Failure in Diabetes
23. Epidemiology of Heart Failure in Diabetes
Association of Diabetes and Incident Heart Failure
Prevalence of Heart Failure and Cardiac Dysfunction in People with Diabetes
Prevalence of Diabetes in Patients with Heart Failure
Incident Diabetes in Patients with Heart Failure
Diabetes and Adverse Outcomes in Heart Failure Patients
Summary
24. Diabetic Cardiomyopathy: Mediators and Mechanisms
Acknowledgments
Scope of the Problem
Epidemiological Evidence
Pathophysiology and Molecular Mechanisms
Unfolded Protein Response
Autophagy
Current Treatment Strategies and Potential Therapeutic Targets
Conclusions and Perspective
25. Prevention of Heart Failure in Patients with Diabetes
Strategies For Prevention of Heart Failure
Identifying Precursors of Symptomatic Heart Failure
Screening Strategies for Prevention of Heart Failure
Strategies for Risk Modification
Challenges in Prevention of Heart Failure and Future Directions
26. Treatment of Heart Failure in Diabetes: Systolic Dysfunction, Diastolic Dysfunction, and Post-Acute Coronary Syndrome
Treatment of Heart Failure in Patients with Diabetes Mellitus
Exercise Prescription
Treatment of Diabetes in Patients with Heart Failure
Summary
Part VI: Other Di