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Each volume in the Early Detection and Treatment of Cancer Series is packed with practical, authoritative information designed to cover the full range of diagnostic procedures, including pathologic, radiologic, bronchoscopic, and surgical aspects. You’ll be able to determine the safest, shortest, least invasive way to reach an accurate diagnosis; stage the disease; and choose the best initial treatment for early stages. Based on current evidence in the literature, authors provide clinical, hands-on tools to help you make informed decisions on precisely what tests and imaging studies are needed to diagnose and stage each type of cancer. Practical, authoritative, and highly-illustrated, this volume in the brand new Early Detection and Treatment of Cancer series covers current protocols and the latest advances in diagnostic imaging and molecular and serologic markers for breast cancer. Apply expert advice on the best “next-step plan for different presentations and tips for less invasive protocols. Get clinical, hands-on tools to help you make informed decisions on precisely what tests and imaging studies are needed for accurate diagnosis and staging. Clear figures, tables, and boxes illustrate step-by-step care of the full range of problems encountered. The small size and convenient format make this an ideal purchase for diagnostic reference.
  • Outlines the steps after diagnosis to guide you through formulating a treatment or patient care plan.
  • Emphasizes important points—such as the promising new breast cancer vaccine, sentinel node biopsy, and hormone receptor tests—with “key points boxes at the beginning of each chapter and pedagogic features throughout.
  • Summarizes the process of accurately diagnosing and staging cancer in a logical, almost algorithmic, approach for easy reference.
  • Discusses the treatment of early-stage disease so you have clear options for care.
  • Complements the procedures outlined in the text with full-color photographs and line drawings to reinforce your understanding of the material.



Publié par
Date de parution 15 juillet 2010
Nombre de lectures 0
EAN13 9781437736106
Langue English
Poids de l'ouvrage 5 Mo

Informations légales : prix de location à la page 0,0421€. Cette information est donnée uniquement à titre indicatif conformément à la législation en vigueur.


Early Diagnosis and Treatment of Cancer: Breast Cancer

Lisa Jacobs, MD
Associate Professor, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland

Christina A. Finlayson, MD
Professor, Department of Surgery, University of Colorado School of Medicine, Aurora, Colorado
1600 John F. Kennedy Blvd.
Ste 1800
Philadelphia, PA 19103-2899
ISBN-13: 978-1-4160-4932-6
Copyright © 2011 by Saunders, an imprint of Elsevier Inc. All rights reserved.
No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any information storage and retrieval system, without permission in writing from the publisher. Details on how to seek permission, further information about the Publisher’s permissions policies and our arrangements with organizations such as the Copyright Clearance Center and the Copyright Licensing Agency, can be found at our website: www.elsevier.com/permissions .
This book and the individual contributions contained in it are protected under copyright by the Publisher (other than as may be noted herein).

Knowledge and best practice in this field are constantly changing. As new research and experience broaden our understanding, changes in research methods, professional practices, or medical treatment may become necessary.
Practitioners and researchers must always rely on their own experience and knowledge in evaluating and using any information, methods, compounds, or experiments described herein. In using such information or methods they should be mindful of their own safety and the safety of others, including parties for whom they have a professional responsibility.
With respect to any drug or pharmaceutical products identified, readers are advised to check the most current information provided (i) on procedures featured or (ii) by the manufacturer of each product to be administered, to verify the recommended dose or formula, the method and duration of administration, and contraindications. It is the responsibility of practitioners, relying on their own experience and knowledge of their patients, to make diagnoses, to determine dosages and the best treatment for each individual patient, and to take all appropriate safety precautions.
To the fullest extent of the law, neither the Publisher nor the authors, contributors, or editors, assume any liability for any injury and/or damage to persons or property as a matter of products liability, negligence or otherwise, or from any use or operation of any methods, products, instructions, or ideas contained in the material herein.
Library of Congress Cataloging-in-Publication Data
Early diagnosis and treatment of cancer : breast cancer / edited by Lisa Jacobs and Christina A. Finlayson
p. ; cm.—(Early diagnosis and treatment of cancer series)
Includes bibliographical references.
ISBN 978-1-4160-4932-6
1. Breast—Cancer. I. Jacobs, Lisa. II. Finlayson, Christina A. III. Series: Early diagnosis and treatment of cancer series.
[DNLM: 1. Breast Neoplasms—diagnosis. 2. Breast Neoplasms—therapy. 3. Early Diagnosis. WP 870 B6205 2010]
RC280.B8B6655626 2011
Acquisitions Editor: Dolores Meloni
Design Direction: Steven Stave
Early Diagnosis and Treatment of Cancer
Series Editor: Stephen C. Yang, MD
Breast Cancer
Edited by Lisa Jacobs and Christina A. Finlayson
Colorectal Cancer
Edited by Susan Lyn Gearhart and Nita Ahuja
Head and Neck Cancer
Edited by Wayne M. Koch
Ovarian Cancer
Edited by Robert E. Bristow and Deborah K. Armstrong
Prostate Cancer
Edited by Li-Ming Su
Printed in the United States of America
Last digit is the print number: 9 8 7 6 5 4 3 2 1
To all women who have participated in clinical trials. These are the true heroes of breast cancer research; their courage and generosity have paved the way for each improvement in breast cancer therapy.
To my daughters Catherine and Elizabeth in the hopes that the continuing research prevents them from ever facing this disease.
Endless thanks to my parents, Richard and Ann Finlayson, without whom I would have never started on this path, and my husband, Emerson Lomaquahu, whose love and support keep me going.
Series Preface
Seen on a graph, the survival rate for many cancers resembles a precipice. Discovered at an early stage, most cancers are quickly treatable, and the prognosis is excellent. In late stages, however, the typical treatment protocol becomes longer, more intense, and more harrowing for the patient, and the survival rate declines steeply. No wonder, then, that one of the most important means in fighting cancer is to prevent or screen for earlier stage tumors.
Within each oncologic specialty, there is a strong push to identify new, more useful tools for early diagnosis and treatment, with an emphasis on methods amenable to an office-based or clinical setting. These efforts have brought impressive results. Advances in imaging technology, as well as the development of sophisticated molecular and biochemical tools, have led to effective, minimally invasive approaches to cancer in its early stages.
This series, Early Diagnosis and Treatment of Cancer , gathers state-of-the-art research and recommendations into compact, easy-to-use volumes. For each particular type of cancer, the books cover the full range of diagnostic and treatment procedures, including pathologic, radiologic, chemotherapeutic, and surgical methods, focusing on questions like these:
What do practitioners need to know about the epidemiology of the disease and its risk factors?
How do patients and their families wade through and interpret the myriad of testing?
What is the safest, quickest, least invasive way to reach an accurate diagnosis?
How can the stage of the disease be determined?
What are the best initial treatments for early-stage disease, and how should the practitioner and the patient choose among them?
What lifestyle factors might affect the outcome of treatment?
Each volume in the series is edited by an authority within the subfield, and the contributors have been chosen for their practical skills as well as their research credentials. Key Points at the beginning of each chapter help the reader grasp the main ideas at once. Frequent illustrations make the techniques vivid and easy to visualize. Boxes and tables summarize recommended strategies, protocols, indications and contraindications, important statistics, and other essential information. Overall, the attempt is to make expert advice as accessible as possible to a wide variety of health care professionals.
For the first time since the inception of the National Cancer Institute’s annual status reports, the 2008 “Annual Report to the Nation on the Status of Cancer,” published in the December 3 issue of the Journal of the National Cancer Institute , noted a statistically significant decline in “both incidence and death rates from all cancers combined.” This mark of progress encourages all of us to press forward with our efforts. I hope that the volumes in Early Diagnosis and Treatment of Cancer will make health care professionals and patients more familiar with the latest developments in the field, as well as more confident in applying them, so that early detection and swift, effective treatment become a reality for all of our patients.

Stephen C. Yang, MD, The Arthur B. and Patricia B. Modell Professor of Thoracic Surgery, Chief of Thoracic Surgery, The Johns Hopkins Medical Institutions, Baltimore, Maryland
Breast cancer is the most common malignancy to occur in women. It is estimated that in 2009 approximately 192,500 women were diagnosed with invasive breast cancer and 62,300 were diagnosed with in situ disease. Breast cancer is the second most common cause of cancer death in women, with an estimated 40,000 women dying of the disease in 2009. The combination of the high incidence of the disease, strong grassroots advocacy, and consistent, focused research has resulted in numerous advances in the treatment of breast cancer over the past several decades. In this book we provide a comprehensive review of current recommendations for the clinical management of early breast cancer, including prevention, diagnosis, and treatment. We also include some of the new and innovative interventions on the horizon that have not yet become standard.
The battle against breast cancer mortality begins with prevention. The decision to pursue breast cancer prevention must be based on an accurate assessment of risk, and this risk assessment is aided by risk assessment models. For patients at very high risk, genetic assessment with germ-line gene mutation testing such as BRCA becomes important. Even for those patients without a genetic mutation or at low risk for a mutation, interventions for breast cancer prevention may still be desirable. Previously, surgery was the only option for risk reduction, but now hormonal therapies are available. In addition, evidence is building for lifestyle changes that each individual woman can adopt to reduce her personal risk of developing breast cancer. These options provide the patient and the physician with a range of effective risk reduction strategies that can then be selected to meet the patient’s desired level of risk reduction while taking into consideration the risks and process involved i

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