From Auto- to Allotransplantation

Description

This unique publication was written by experts who have made significant contributions to the development of reconstructive microsurgery and vascularized composite allotransplantation and are likely to shape its future. The book is divided into three major sections. The first presents the state-of-the-art of autologous microsurgical reconstruction. It summarizes current achievements, highlights the shortcomings of currently available techniques, and prepares the reader for the next evolutionary step: allotransplantation. Section two is a comprehensive review of allotransplantation, from immunology to surgical techniques. Finally, for those interested in establishing a comprehensive center for vascularized composite allotransplantation, section three provides important lessons from the successful Chang Gung Vascularized Composite Allotransplantation Center. From Auto- to Allotransplantation is indeed the only up-to-date and complete reference available on the topic. Scholars and research fellows interested in transplantation will benefit greatly from this work. It is also an invaluable resource for plastic, orthopedic, hand, ENT, oromaxillofacial, and general surgeons as well as for residents.

Informations

• Publié par: S. Karger AG
• Date de parution: 28 juin 2016
• Nombre de lectures: 0
• EAN13: 9783318058673
• Langue: English
• Poids de l'ouvrage: 2 Mo

Extrait

From Auto- to Allotransplantation
Translational Research in Biomedicine
Vol. 5
Series Editor
Samuel H.H. Chan Kaohsiung
Associate Editor
Julie Y.H. Chan Kaohsiung
The Chang Gung Medical Foundation is the patron of this book series.
From Auto- to Allotransplantation
Volume Editors
Fu-Chan Wei Taipei
Hui-Yun Cheng Taoyuan
Cheng-Hung Lin Taoyuan
46 figures, 43 in color, and 3 tables, 2016
_______________________ Fu-Chan Wei Department of Plastic and Reconstructive Surgery Chang Gung Memorial Hospital 199 Tun-Hwa North Road Taipei 105 Taiwan, ROC
_______________________ Hui-Yun Cheng Center for Vascularized Composite Allotransplantation Chang Gung Memorial Hospital 5 Fu-Hsing Street, Guishan District Taoyuan 333 Taiwan, ROC
_______________________ Cheng-Hung Lin Department of Plastic and Reconstructive Surgery Chang Gung Memorial Hospital 5 Fu-Hsing Street, Guishan District Taoyuan 333 Taiwan, ROC
Library of Congress Cataloging-in-Publication Data
Names: Wei, Fu-Chan, editor. | Cheng, Hui-Yun, editor. | Lin, Cheng-Hung (Of Changgeng ji nian yi yuan), editor.
Title: From auto- to allotransplantation / volume editors, Fu-Chan Wei, Hui-Yun Cheng, Cheng-Hung Lin.
Other titles: Translational research in biomedicine ; v. 5. 1662-405X
Description: Basel ; New York: Karger, [2016] | Series: Translational research in biomedicine, ISSN 1662-405X ; vol. 5 | Includes bibliographical references and indexes.
Identifiers: LCCN 2016017108| ISBN 9783318058666 (hard cover: alk. paper) | ISBN 9783318058673 (electronic version)
Subjects: | MESH: Vascularized Composite Allotransplantation | Transplantation, Autologous | Reconstructive Surgical Procedures--methods | Microsurgery
Classification: LCC RD120.7 | NLM WO 660 | DDC 617.9/5--dc23 LC record available at https://lccn.loc.gov/2016017108

Disclaimer. The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publisher and the editor(s). The appearance of advertisements in the book is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
Drug Dosage. The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any change in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
© Copyright 2016 by S. Karger AG, P.O. Box, CH-4009 Basel (Switzerland)
www.karger.com
Printed in Germany on acid-free and non-aging paper (ISO 9706) by Kraft Druck GmbH, Ettlingen
ISSN 1662-405X
e-ISSN 1662-4068
ISBN 978-3-318-05866-6
e-ISBN 978-3-318-05867-3
Contents
Foreword
Chan, S.H.H. (Kaohsiung)
Preface
Wei, F.-C. (Taipei); Cheng, H.-Y.; Lin, C.-H. (Taoyuan)
Section I: State of the Art in Microsurgical Autotransplantation
Microsurgical Reconstruction in Brachial Plexus Injury and Facial Paralysis
Chuang, D.C.-C. (Taoyuan)
Microsurgical Reconstruction of Oncological Defects
Cheng, M.-H.; Browne, T. (Taoyuan)
Various Free Intestinal Flaps and Omentum for Reconstruction of Defects
Maruccia, M.; Chen, H.-C. (Taichung)
Achieving Norms: Limitations of Autotransplantation and the Need for Allotransplantation Illustrated with Head and Neck Reconstruction
Al Deek, N.F.; Tsao, C.-K.; Wei, F.-C. (Taoyuan)
Evolution from Toe-to-Hand Transfer to Hand Transplantation
Zelken, J.; Lin, C.-H. (Taoyuan)
Section II: Clinical Vascularized Composite Allotransplantation
Vascularized Composite Allografts and Solid Organ Transplants: Similarities and Differences
Weissenbacher, A.; Grahammer, J.; Hautz, T.; Schneeberger, S. (Innsbruck)
Development of a Clinical Vascularized Composite Allotransplantation Program: Requirements and Recommendations
Lawson, S.; Wang, L. (San Antonio, Tex.); Fries, C.A. (Birmingham); Davis, M. (San Antonio, Tex.); Gorantla, V.S. (Pittsburgh, Pa.)
Hand Transplantation
Brandacher, G.; Shores, J.T.; Lee, W.P.A. (Baltimore, Md.)
Facial Transplantation
Aycart, M.; Alhefzi, M.; Kueckelhaus, M.; Fischer, S.; Dermietzel, A.; Wo, L.; Bueno, E.; Pribaz, J.J.; Pomahac, B. (Boston, Mass.)
Section III: Basic and Translational VCA Research at Chang Gung
Establishing a Center for Vascularized Composite Allotransplantation: The Experience of Chang Gung Memorial Hospital
Cheng, H.-Y.; Al Deek, N.F.; Wei, F.-C. (Taoyuan)
Development of Animal Models for the Study of Vascularized Composite Allotransplantation
Zelken, J.; Lin, C.-H. (Taoyuan)
Induction of Donor-Specific Tolerance with Vascularized Bone Marrow Transplantation
Lin, C.-H.; Anggelia, M.R. (Taoyuan)
Cellular Therapeutics-Based Strategies for Inducing Donor-Specific Tolerance to Vascularized Composite Allotransplants
Cheng, H.-Y. (Taoyuan)
In vivo Bioimaging Platform with Tissomic Validation for Vascularized Composite Allotransplantation
Wen, C.-J.; Hsieh, Y.-H. (Taoyuan)
Potential of MicroRNAs in Vascularized Composite Allotransplantation
Hsieh, C.-H. (Kaohsiung)
Potential of Induced Pluripotent Stem Cells in Vascularized Composite Allotransplantation
Wang, A.Y.L. (Taoyuan)
Author Index
Subject Index
Foreword
Welcome to volume 5 of Translational Research in Biomedicine, a monograph series dedicated to the dissemination of seminal information in contemporary biomedicine with a translational orientation. This volume marks the third installment of this series under the generous patronage of Chang Gung Medical Foundation, Taiwan. This patronage reduces substantially the increasing financial constraints on scientific publication, and allows us to concentrate on publishing timely and crucial themes in translational medicine.
This volume is designed to be a key reference on the evolution of reconstructive microsurgery, from free autologous tissue transfer to vascularized composite allotransplantation. Despite the high success rate of microsurgical autotransplantation in the hands of these surgeons, there are still body defects that are too complex to be remedied by reconstruction with autologous tissue. Although still in its infancy, clinical vascularized composite allotransplantation offers a revolutionary approach that not only pushes the forefronts of reconstructive surgery to another level, but offers a viable alternative to improve the quality of life of afflicted patients. Authored by pioneers in reconstructive surgery, the narratives are essentially recapitulations of personal experiences of practitioners who set new trends in this field. In the spirit of translational medicine, this clinical know-how is accompanied by parallel research development in immunology and cell biology aiming at achieving donor-specific tolerance.
I wish to express my deepest appreciation to Drs. Fu-Chan Wei, Hui-Yun Cheng, and Cheng-Hung Lin, who despite their heavy clinical commitments have made this timely volume on the devolpments 'from auto- to allotransplantation' a reality. I also wish to acknowledge the capable hands of Thomas Nold, Freddy Brian, and Magdalena Mühlemann at S. Karger AG during the development and production of this volume. Last but not least, the publication of Translational Research in Biomedicine would not have been possible without the foresight, enthusiasm, and whole-hearted support of my dear friend, Dr. Thomas Karger.
Samuel H.H. Chan, Kaohsiung Series Editor
Preface
Autologous free tissue transfer has been the epitome of reconstruction for cancer, trauma, and congenital deformities over the past four decades. However, in spite of accumulation of experience and achieving high success rates in microsurgical reconstruction, there are still a few complex and/or extensive defects that need to be addressed. As a result, allotransplantation has grown, inevitably aiming for more and pushing a new paradigm in reconstructive surgery for enhancing the quality of life for those deemed unreconstructable and who need a revolutionary solution. So far, new life has been given to nearly 200 patients who have received a wide array of hand, abdominal wall, and face allotransplantations.
This book follows the evolution of reconstructive microsurgery from free autologous tissue transfer to vascularized composite allotransplantation in three sections. Section I concentrates on the state of the art in microsurgery, capitalizing on more than 20,000 cases of microsurgical free flap reconstruction experience from head to toe and their limitations at Chang Gung Memorial Hospital, preparing the readers for the next leap addressed in Section II. Section II focuses on allotransplantation, with the opening chapte