Human Papillomavirus

Description

Human papillomavirus (HPV) infection transcends multiple fields of science and medicine. The management of HPV-related disease is demanding and often requires a persistent multimodal approach involving various medical disciplines. In this volume, experts present a comprehensive view of HPV research with an emphasis on clinical presentations, diagnosis, management and vaccine development. The state of the art in molecular biology is provided in addition to discussions on clinical morphology and the utility of dermatoscopy in identifying HPV disease. In a multidisciplinary approach to dermatological, plastic and reconstructive, gynecological, otolaryngological and colorectal management, different treatment strategies are highlighted. Finally, Dr. Neil Christensen discusses viral immunology, and the difficulties and successes in the development of an HPV vaccine.
Bringing together basic science and clinical information on HPV, this book is an excellent resource and reference for all researchers and clinicians who encounter human papillomavirus-related disease.

Informations

• Publié par: S. Karger AG
• Date de parution: 13 mars 2014
• Nombre de lectures: 0
• EAN13: 9783318025279
• Langue: English
• Poids de l'ouvrage: 2 Mo

Extrait

Human Papillomavirus: Bench to Bedside
Current Problems in Dermatology
Vol. 45
Series Editors
Peter Itin Basel
Gregor B.E. Jemec Roskilde
Human Papillomavirus
Bench to Bedside
Volume Editors
Marigdalia K. Ramírez-Fort Houston, Tex.
Farhan Khan Houston, Tex.
Peter L. Rady Houston, Tex.
Stephen K. Tyring Houston, Tex.
61 figures, 55 in color, and 15 tables, 2014
Current Problems in Dermatology
_______________________ Marigdalia K. Ramírez-Fort Farhan Khan Stephen K. Tyring Center for Clinical Studies Houston, TX (USA)
_______________________ Peter L. Rady Department of Dermatology The University of Texas Health Science Center at Houston Houston, TX (USA)



Library of Congress Cataloging-in-Publication Data
Human papillomavirus (Ramírez-Fort)
Human papillomavirus: bench to bedside / volume editors, Marigdalia K. Ramírez-Fort, Farhan Khan, Peter L. Rady, Stephen K. Tyring.
p. ; cm. –– (Current problems in dermatology, ISSN 1421-5721 ; v. 45)
Includes bibliographical references and index.
ISBN 978-3-318-02526-2 (hard cover: alk. paper) –– ISBN 978-3-318-02527-9 (electronic version)
I. Ramírez-Fort, Marigdalia K., editor of compilation. II. Khan, Farhan, editor of compilation. III. Rady, Peter L., editor of compilation. IV. Tyring, Stephen K. (Stephen Keith), editor of compilation. V. Title. VI. Series: Current problems in dermatology ; v. 45. 1421-5721
[DNLM: 1. Papillomavirus Infections. 2. Papillomaviridae. W1 CU804L v.45 2014 / QZ 200]
RC168.P15
616.9’11––dc23
2014003258
Bibliographic Indices. This publication is listed in bibliographic services, including MEDLINE/Pubmed.
Disclaimer. The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publisher and the editor(s). The appearance of advertisements in the book is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
Drug Dosage. The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any change in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
© Copyright 2014 by S. Karger AG, P.O. Box, CH-4009 Basel (Switzerland)
www.karger.com
Printed in Germany on acid-free and non-aging paper (ISO 9706) by Kraft Druck GmbH, Ettlingen
ISSN 1421-5721
e-ISSN 1662-2944
ISBN 978-3-318-02526-2
e-ISBN 978-3-318-02527-9
Contents
Foreword
Brodell, R.T. (Mississippi/New York)
Introduction
Human Papillomavirus Genomics: Past, Present and Future
Harari, A.; Chen, Z.; Burk, R.D. (Bronx, N.Y.)
Molecular Biology and Pathogenesis
The Biology of Human Papillomaviruses
Nguyen, H.P.; Ramírez-Fort, M.K.; Rady, P.L. (Houston, Tex.)
Viral Oncogenesis
Doan, H.Q. (Galveston, Tex.); Ramírez-Fort, M.K.; Rady, P.L. (Houston, Tex.)
Pathogenesis of Infection by Human Papillomavirus
Brendle, S.A.; Bywaters, S.M.; Christensen, N.D. (Hershey, Pa.)
Host Responses to Infection with Human Papillomavirus
Stanley, M.A.; Sterling, J.C. (Cambridge)
Epidemiology and Clinical Manifestations
The Epidemiology of Human Papillomaviruses
Nyitray, A.G. (Houston, Tex.); Iannacone, M.R. (Brisbane, Qld.)
Cutaneous Human Papillomavirus Infection: Manifestations and Diagnosis
Tschandl, P. (Vienna); Rosendahl, C. (Brisbane, Qld.); Kittler, H. (Vienna)
Genitoanal Human Papillomavirus Infection and Associated Neoplasias
Gross, G. (Rostock)
Epidermodysplasia Verruciformis
Burger, B.; Itin, P.H. (Basel)
Human Papillomavirus Infections of the Oral Mucosa and Upper Respiratory Tract
Nguyen, H.P.; McNiece, K.L. (Houston, Tex.); Duong, A.A. (Austin, Tex.); Khan, F. (Houston, Tex.)
Human Papillomavirus and Immunosuppression
Wieland, U. (Cologne); Kreuter, A. (Oberhausen); Pfister, H. (Cologne)
Laboratory Diagnosis
Laboratory Diagnosis of Human Papillomavirus Infection
Ikenberg, H. (Frankfurt)
Treatment and Prevention
Management of Cutaneous Human Papillomavirus Infection: Pharmacotherapies
Ramírez-Fort, M.K.; Au, S.-C. (Boston, Mass.); Javed, S.A. (Houston, Tex.); Loo, D.S. (Boston, Mass.)
Management of Cutaneous Human Papillomavirus Infection: Surgery
Ramírez-Fort, M.K. (Boston, Mass.); Sam, H.; Manders, E.K. (Pittsburgh, Pa.)
Management of Cutaneous Human Papillomavirus Infection in Immunocompromised Patients
Varada, S.; Posnick, M.; Alessa, D. (Boston, Mass.); Ramírez-Fort, M.K. (Boston, Mass./Houston, Tex.)
Management of Human Papillomavirus-Related Gynecological Malignancies
Heinzelmann-Schwarz, V.A.; Kind, A.B.; Jacob, F. (Basel)
Management of Human Papillomavirus-Related Anal and Colon Cancer
Yen Moore, A. (Arlington, Tex./Dallas, Tex./Galveston, Tex.); Tong, L.X. (Los Angeles, Calif.); Moore, T. (Arlington, Tex.)
Management of Human Papillomavirus-Related Head and Neck Cancer
Coughlin, A.M.; Qiu, S.; Underbrink, M.P. (Galveston, Tex.)
Vaccines and Immunization against Human Papillomavirus
Christensen, N.D.; Budgeon, L.R. (Hershey, Pa.)
Author Index
Subject Index
Foreword
It’s about time! Finally, information that is scattered throughout the worldwide web and in thousands of books and journal articles from a range of clinical and basic science disciplines is pulled together into one tome. This innovative book is truly the definitive treatise on human papillomaviruses (HPV). The clinical chapters include the latest information on the manifestations of HPV disease, diagnosis, and management. Included are current therapeutic guidelines, and prevention of warts in a manner that emphasizes the efficacy and side effects of different treatment modalities. It is organized in a manner so that specific information can be easily and quickly accessed. The research chapters are understandable by both the clinician and the researcher and provide a comprehensive view of the state of HPV science with an emphasis on vaccine development.
Most importantly for the first time, basic science and clinical information on HPV are presented together in the same book. Research in the 21st century is increasingly focused on translational efforts that require an interchange of ideas between researchers and clinicians. Successful grant applications take the latest information from the bench and focus it on bedside applications. At the same time, deficiencies in both diagnostic and therapeutic approaches must be identified to plug gaps in knowledge by targeting research to solve clinical problems. I am certain a broad swath of bench researchers, clinicians from the fields of dermatology, gynecology, surgery, and primary care fields will find this book to be a helpful reference whether read cover to cover or used when questions arise in their work. With just a little luck, the cross-pollination of research and clinical ideas will stimulate creative thinking that will stimulate creative advances in this field. It’s about time!

Robert T. Brodell, MD
Professor and Chair, Department of Dermatology
Professor of Pathology
University of Mississippi Medical Center
Jackson, Mississippi
Instructor in Dermatology
University of Rochester School of Medicine and Dentistry
Rochester, New York
Introduction
Ramírez-Fort MK, Khan F, Rady PL, Tyring SK (eds): Human Papillomavirus: Bench to Bedside. Curr Probl Dermatol. Basel, Karger, 2014, vol 45, pp 1-18 (DOI: 10.1159/000355952)
______________________
Human Papillomavirus Genomics: Past, Present and Future
Ariana Harari a Zigui Chen b Robert D. Burk a - d
Departments of a Microbiology and Immunology, b Pediatrics, c Obstetrics, Gynecology and Women’s Health, and d Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, N.Y., USA
______________________
Abstract
Human papillomaviruses (HPV) are a group of divergent DNA viruses, of which a select few evolutionarily related HPVs have emerged to be highly oncogenic and of significant medical importance. Essentially all cases of cervical cancer, as well as a subset of other anogenital and oral cancers are caused by this limited set of HPV types. At present, over 150 HPV types have been identified and may be classified into genera, species and types based upon comparison of the viral genome. Established nucleotide phylogenies sort the highly pathogenic HPV types to the genus Alphapapillomavirus (α-PV). A species group