Intracranial Gliomas Part II - Adjuvant Therapy

Description

Treatment of patients with intracranial gliomas, especially high-grade neoplasms, usually requires postoperative adjuvant therapy. Significant progress in the understanding of tumor biology, technological advances in irradiation delivery, and development of novel antitumor drugs have led to an expansion of the therapeutic arsenal in neuro-oncology. This publication provides a unique review of the various options for adjuvant therapy. Special emphasis is on current evidence-based treatment standards and guidelines, and on perspectives of further improvement in long-term outcomes. Chapters review the histopathological and molecular features of gliomas and describe basic principles and clinical results of fractionated radiotherapy, stereotactic radiosurgery, brachytherapy, use of radiosensitizers, systemic chemotherapy and antiangiogenic therapy. Particular attention is paid to treatment of pediatric patients and to physical and psychological rehabilitation and supportive care at the end of life. This book and its accompanying volumes are mainly directed at neuro-oncologists, radiation oncologists, and other clinicians treating patients with brain tumors.

Informations

• Publié par: S. Karger AG
• Date de parution: 25 janvier 2018
• Nombre de lectures: 0
• EAN13: 9783318060591
• Langue: English
• Poids de l'ouvrage: 2 Mo

Extrait

Intracranial Gliomas
Part II – Adjuvant Therapy
Progress in Neurological Surgery
Vol. 30
Intracranial Gliomas
Part I – Surgery
Vol. 31
Intracranial Gliomas
Part II – Adjuvant Therapy
Vol. 32
Intracranial Gliomas
Part III – Innovative Treatment Modalities
Series Editor
L. Dade Lunsford Pittsburgh, PA
Intracranial Gliomas
Part II – Adjuvant Therapy
Volume Editors
Mikhail F. Chernov Tokyo
Yoshihiro Muragaki Tokyo
Santosh Kesari Santa Monica, CA
Ian E. McCutcheon Houston, TX
20 figures, 10 in color, and 25 tables, 2018
_______________________ Mikhail F. Chernov, MD, DMedSci Faculty of Advanced Techno-Surgery and Department of Neurosurgery Tokyo Women’s Medical University Tokyo, Japan
_______________________ Yoshihiro Muragaki, MD, PhD Faculty of Advanced Techno-Surgery and Department of Neurosurgery Tokyo Women’s Medical University Tokyo, Japan
_______________________ Santosh Kesari, MD, PhD, FANA, FAAN John Wayne Cancer Institute Pacific Neuroscience Institute at Providence Saint John’s Health Center Santa Monica, CA, USA
_______________________ Ian E. McCutcheon, MD, CM, FRCS(C), FACS Department of Neurosurgery The University of Texas MD Anderson Cancer Center Houston, TX, USA
Library of Congress Cataloging-in-Publication Data
Names: Chernov, Mikhail F., editor. | Muragaki, Yoshihiro, editor. | Kesari, Santosh, editor. | McCutcheon, Ian E., editor.
Title: Intracranial gliomas. Part I, Surgery / volume editors, Mikhail F. Chernov, Yoshihiro Muragaki, Santosh Kesari, Ian E. McCutcheon.
Other titles: Surgery | Progress in neurological surgery ; v. 30. 0079-6492
Description: Basel ; New York : Karger, 2018. | Series: Progress in neurological surgery, ISSN 0079-6492 ; vol. 30 | Includes bibliographical references and indexes.
Identifiers: LCCN 2017020659| ISBN 9783318060560 (hard cover : alk. paper) | ISBN 9783318060577 (electronic version)
Subjects: | MESH: Glioma--surgery
Classification: LCC RD662.5 | NLM QZ 380 | DDC 616.99/481059--dc23 LC record available at https://lccn.loc.gov/2017020659
 
Bibliographic Indices. This publication is listed in bibliographic services, including Current Contents ® and PubMed/MEDLINE.
Disclaimer. The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publisher and the editor(s). The appearance of advertisements in the book is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
Drug Dosage. The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any change in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
© Copyright 2018 by S. Karger AG, P.O. Box, CH–4009 Basel (Switzerland)
www.karger.com
Printed on acid-free and non-aging paper (ISO 9706)
ISSN 0079–6492
e-ISSN 1662–3924
ISBN 978–3–318–06058–4
e-ISBN 978–3–318–06059–1
To my friends; with special thanks to Ms. Maria Tikhonova for her constant support and encouragement during my work with this book. M.F. Chernov
To my colleagues, my mentors, and my family. Y. Muragaki
To my family for supporting me in my academic endeavors and to my patients for providing hope. S. Kesari
To my wife Melly, with love; and in memory of Samuel Hassenbusch, MD, neurosurgeon, scientist, and friend, who died too soon of the disease this book covers. I.E. McCutcheon
Contents
Series Editor’s Note
Lunsford, L.D. (Pittsburgh, PA)
Preface
Chernov, M.F., Muragaki, Y. (Tokyo); Kesari, S. (Santa Monica, CA); McCutcheon, I.E. (Houston, TX)
Pathology and Genetics of Gliomas
Komori, T.; Muragaki, Y.; Chernov, M.F. (Tokyo)
Fractionated Radiotherapy of Intracranial Gliomas
Ghia, A.J. (Houston, TX)
Stereotactic Radiosurgery in the Multimodality Management of Residual or Recurrent Glioblastoma Multiforme
Niranjan, A.; Monaco, E.A. III; Kano, H.; Flickinger, J.C.; Lunsford, L.D. (Pittsburgh, PA)
Stereotactic Radiosurgery of Intracranial Low-Grade Gliomas
Ganz, J.C. (Ulverston)
Brachytherapy of Intracranial Gliomas
Nachbichler, S.B.; Kreth, F.-W. (Munich)
Irradiation of Intracranial Gliomas in Children
Kortmann, R.-D.; Seidel, C.; Müller, K.; Hirsch, F.W. (Leipzig)
Role of Radiosensitizers in Radiation Treatment of Gliomas
Cohen, R.J.; Mehta, M.P. (Baltimore, MD)
Chemotherapy of High-Grade Astrocytomas in Adults
Puduvalli, V.K.; Hoang, N. (Columbus, OH)
Chemotherapy of Diffuse Astrocytoma (WHO grade II) in Adults
Narita, Y. (Tokyo)
Chemotherapy of Oligodendrogliomas
Drappatz, J.; Lieberman, F. (Pittsburgh, PA)
Chemotherapy of Intracranial Gliomas in Children
Terashima, K. (Tokyo)
Perspectives of Personalized Chemotherapy of Gliomas Based on Molecular Tumor Profiling
Soffietti, R.; Franchino, F.; Magistrello, M.; Pellerino, A.; Rudà, R. (Turin)
Antiangiogenic Therapy of High-Grade Gliomas
Jo, J.; Wen, P.Y. (Boston, MA)
Search for More Effective Chemotherapeutic Regimens for Gliomas: Challenges and Hopes
Hu, J. (Los Angeles, CA); Kesari, S. (Santa Monica, CA)
Physical and Psychological Rehabilitation of Patients with Intracranial Glioma
Andrejeva, J. (Klaipeda); Volkova, O.V. (Krasnoyarsk)
Palliative and Supportive Care of Patients with Intracranial Glioma
Pace, A.; Villani, V. (Rome)
Author Index
Subject Index
For Vols. 30 and 32 go to http://www.karger.com/BookSeries/Home/223949
Series Editor’s Note
During more than 20 years I have had the opportunity to collaborate with Karger Publishers on a series of volumes related to advances in neurosurgery. Each book has had one or more editors who collaborate to produce high quality and topical reports on disorders of the nervous system and methods to diagnose and treat them. I am especially indebted to Mr. Thomas Nold and Mr. Freddy Brian who have been partners in these publications.
Dr. Mikhail Chernov first posed a volume on intracranial gliomas three years ago, and assembled a distinguished panel of colleagues—Drs. Yoshihiro Muragaki, Santosh Kesari, and Ian McCutcheon—to oversee the creation of this three-part analysis of intracranial gliomas. Part I describes current surgical concepts. Part II defines the need for and the current types of adjuvant options that are often required after surgical treatment. Part III reports both current and potential future advances that will improve the outcomes of patients with these difficult tumors. They are difficult because of their often invasive and recurrent nature, their varied molecular characteristics, their anatomic site of origin, and their need for multimodality management in many patients.
This project grew to a much bigger venture than either the editors, the authors, the series editor, or the publisher imagined. Dr. Chernov and colleagues pursued the brightest and best minds from many outstanding medical centers across the world. The culmination of this effort led to the need to produce three volumes, together totaling 690 pages. These books are beautifully edited and illustrated. The editors and authors are to be congratulated.
Part II – Adjuvant Therapy provides an up to date comprehensive review of the pathology and continually emerging knowledge base about the genetics of gliomas, followed by specific therapies that are necessary in many glioma patients. This includes current concepts of radiation therapy, radiosurgery, and chemotherapeutic options.
It concludes with reports on the challenges that brain gliomas present, and the role of rehabilitation, palliation, and supportive care of patients.
L. Dade Lunsford , MD, FACS, FAANS, Pittsburgh, PA
Preface
With this, the second of three consecutive volumes of Progress in Neurological Surgery devoted to current management of intracranial gliomas, we present to the medical community Part II, dedicated to postoperative adjuvant therapy. Such treatment is frequently required after primary resection or at the time of progression of brain tumor, especially one of high grade. Significant progress in our understanding of tumor biology, technological advances in delivery of radiotherapy, and development of novel antitumor agents have led to prominent expansion of the therapeutic arsenal in neuro-oncology. Cell lineage-oriented classification of gliomas no longer appears to satisfy the pathological and clinical needs, and profilin