Milk, Mucosal Immunity and the Microbiome: Impact on the Neonate

Description

Considerable advances have been made in science in order to understand the varied mixture of bioactive components in human milk. The 94th Nestlé Nutrition Institute Workshop was designed to provide a comprehensive overview of the latest findings in human milk research and its potential to modulate mucosal immunity, the microbiome, and its impact on the neonate. The publication provides a balanced state-of-the-art update on the current knowledge about milk, mucosal immunity, and the microbiome as well as their impact on breastfeeding in mammalian neonates. The first part reviews data on the immunology of milk and lactation from a historical perspective to the latest scientific findings. The second part discusses the microbiology of human milk and lactation in detail, with a focus on premature infants and necrotizing enterocolitis. And finally, in the third part, light is shed on the protective factors in human milk and their role in influencing the neonate’s immune system. Important new insights will provide great scientific support for all people seeking a deeper understanding of human milk and its immunological properties and will enlarge the knowledge of those who have already specialized in human milk research.

Informations

• Publié par: S. Karger AG
• Date de parution: 24 avril 2020
• Nombre de lectures: 0
• EAN13: 9783318066852
• Langue: English
• Poids de l'ouvrage: 3 Mo

Extrait

Nestlé Nutrition Institute Workshop Series | Vol. 94
Milk, Mucosal Immunity
and the Microbiome:
Impact on the Neonate
Pearay L. Ogra–
W. Allan Walker–
Bo Lönnerdal–Milk, Mucosal Immunity and the Microbiome: Impact on the NeonateNestlé Nutrition Institute
Workshop Series
Vol. 94Milk, Mucosal Immunity
and the Microbiome:
Impact on the Neonate
Editors
Pearay L. Ogra Buffalo, NY
W. Allan Walker Boston, MA
Bo Lönnerdal Davis, CA© 2020 Nestlé Nutrition Institute, Switzerland
CH 1814 La Tour-de-Peilz
S. Karger AG, P.O. Box, CH–4009 Basel (Switzerland) www.karger.com
Library of Congress Cataloging-in-Publication Data
Names: Nestlé Nutrition Workshop (94th : 2019 : Lausanne, Switzerland),
author. | Ogra, Pearay L., editor. | Walker, W. Allan, editor. |
Lönnerdal, Bo, 1938- editor. | Nestlé Nutrition Institute, issuing
body.
Title: Milk, mucosal immunity and the microbiome : impact on the neonate /
editors, Pearay L. Ogra, W. Allan Walker, Bo Lönnerdal.
Other titles: Nestlé Nutrition Institute workshop series ; v. 94.
1664-2147
Description: Basel ; Hartford : Karger ; Switzerland : Nestlé Nutrition
Institute, [2020] | Series: Nestlé Nutrition Institute workshop series,
1664-2147 ; vol. 94 | Includes bibliographical references and index. |
Summary: “This publication covers the 94th Nestle Nutritional Institute
Workshop, which was designed to provide a comprehensive overview on the
latest human milk research and its role in modulating mucosal immunity,
the microbiome, and its impact on the neonate. This publication should
provide scientific support to anyone seeking a deeper understanding of
human milk and its immunological properties, and enlarge the knowledge
of those who specialize in human milk research”-- Provided by publisher.
Identifiers: LCCN 2020007208 (print) | LCCN 2020007209 (ebook) | ISBN
9783318066845 (hardcover ; alk. paper) | ISBN 9783318066852 (ebook)
Subjects: MESH: Infant Nutritional Physiological Phenomena | Milk, Human |
Breast Feeding | Immunity, Mucosal | Microbiota | Infant, Newborn |
Congress
Classification: LCC RJ216 (print) | LCC RJ216 (ebook) | NLM W1 NE228D
v.94 2020 | DDC 613.2/69--dc23
LC record available at https://lccn.loc.gov/2020007208
LC ebook record available at https://lccn.loc.gov/2020007209
The material contained in this volume was submitted as previously unpublished material, except in the instances in
which credit has been given to the source from which some of the illustrative material was derived.
Great care has been taken to maintain the accuracy of the information contained in the volume. However, neither
Nestlé Nutrition Institute nor S. Karger AG can be held responsible for errors or for any consequences arising from
the use of the information contained herein.
© 2020 Nestlé Nutrition Institute (Switzerland) and S. Karger AG, Basel (Switzerland). All rights reserved. This book is
protected by copyright. No part of it may be reproduced, stored in a retrieval system, or transmitted, in any form or
by any means, electronic, mechanical, photocopying, or recording, or otherwise, without the written permission of
the publisher.
Printed on acid-free and non-aging paper (ISO 9706)
ISBN 978–3–318–06684–5
e-ISBN 978–3–318–06685–2
ISSN 1664–2147
e-ISSN 1664–2155
Basel · Freiburg · Hartford · Oxford · Bangkok · Dubai · Kuala Lumpur ·
Melbourne · Mexico City · Moscow · New Delhi · Paris · Shanghai · TokyoContents
VII Preface
X Foreword
XII Contributors
XV Dedication
Immunology of Milk and Lactation
1 The Evolution of Lactation in Mammalian Species
Oftedal, O.T. (USA)
11 Immunology of Human Milk and Lactation: Historical Overview
Ogra, P.L. (USA)
27 The Mammary Gland as an Integral Component of the Common
Mucosal Immune System
Mestecky, J. (USA/Czech Republic)
38 Immunomodulatory Components of Human Colostrum and Milk
Tlaskalová-Hogenová, H.; Kverka, M.; Hrdý, J. (Czech Republic)
48 Breastfeeding, a Personalized Medicine with Influence on Short- and
Long-Term Immune Health
Verhasselt, V. (Australia)
59 Summary on Immunology of Milk and Lactation
Ogra, P.L. (USA)
Microbiology of Milk and Lactation: Influence on Gut Colonization
65 Milk Microbiome and Neonatal Colonization: Overview
Rautava, S. (Finland)
75 Human Milk Microbiota: Origin and Potential Uses
Fernández, L.; Rodríguez, J.M. (Spain)
86 Beyond the Bacterial Microbiome: Virome of Human Milk and
Effects on the Developing Infant
Mohandas, S.; Pannaraj, P.S. (USA)
V 94 Gut Microbiota, Host Gene Expression, and Cell Traffic via Milk
Neu, J. (USA)
103 Breast Milk and Microbiota in the Premature Gut: A Method of
Preventing Necrotizing Enterocolitis
Walker, W.A.; Meng, D. (USA)
113 Summary on Microbiota of Milk and Lactation: Influence on Gut
Colonization
Walker, W.A. (USA)
Protective Factors in Human Milk
115 Human Milk Oligosaccharides: Structure and Functions
Bode, L. (USA)
124 Oligosaccharides and Viral Infection: Human Milk Oligosaccharides
versus Algal Fucan-Type Polysaccharides
Hanisch, F.-G. (Germany); Aydogan, C. (Switzerland)
133 Milk Fat Globule Membranes: Effects on Microbiome, Metabolome,
and Infections in Infants and Children
Hernell, O. (Sweden); Lönnerdal, B. (USA); Timby, N. (Sweden)
141 Clinical Trials of Lactoferrin in the Newborn: Effects on Infection and
the Gut Microbiome
Embleton, N.D.; Berrington, J.E. (UK)
152 Effects of Milk Osteopontin on Intestine, Neurodevelopment,
and Immunity
Jiang, R.; Lönnerdal, B. (USA)
158 Effects of Milk Secretory Immunoglobulin A on the Commensal
Microbiota
Dunne-Castagna, V.P.; Mills, D.A.; Lönnerdal, B. (USA)
169 Summary on Protective Factors in Human Milk
Lönnerdal, B. (USA)
172 Subject Index
For more information on related publications, please consult the NNI website:
www.nestlenutrition-institute.org
ContentsVIPublished online: April 8, 2020
Ogra PL, Walker WA, Lönnerdal B (eds): Milk, Mucosal Immunity and the Microbiome: Impact on the
Neonate. Nestlé Nutr Inst Workshop Ser. Basel, Karger, 2020, vol 94, pp VI–VIII
(DOI:10.1159/000505372)
Preface
Lactation and the process of breastfeeding has been integral to the survival
and long-term well-being of neonates and infants of most mammalian species.
Mothers’ milk has been considered as a complete source of nutrition for the
suckling infant from times immemorial, often with many magical healing powers. It
is only in the past 2 centuries that significant scientific information has become
available about the evolution of the mammary glands and the development of
lactation and its impact on the suckling mammalian neonate. Since the
observations of Paul Ehrlich over 120 years ago, it is now clear that mammalian
breastfeeding is associated with significant reduction in infant mortality, protection
against enteric, respiratory, and other mucosal and systemic infections, and
protection against the development of allergic disorders. Recent observations have
demonstrated that breastfeeding has a profound impact on the development and
function of the neonatal immune system, mucosal microbiological homeostasis,
and long-term protection against autoimmune and other inflammatory disease
states and malignancy. The nutritional and immunobiological benefits attributed
to breastfeeding are related to the diverse spectrum of specific cellular and soluble
products present in the early colostrum and milk. It is now clear that the
immunologic activity in the products of lactation represents the effector functional
elements of the common mucosal immune system. The discovery of the secretory
IgA (SIgA) immunoglobulin isotype in the milk, followed by the identification of
antibacterial, antiviral, and antiparasitic activity in the milk associated with SIgA
and demonstration of important elements of cellular immunity in the milk
represent crucial milestones in the understanding of lactation as the single most
important element of neonatal health in most mammalian species.
The 94th Nestlé Nutrition Institute workshop is dedicated to Prof.
Lars A. Hanson, who was the first investigator to identify SIgA in the colostrum
and milk. He has been one of the most devoted scholars to the study of
mammalian lactation and breastfeeding, and has also been instrumental in a global effort to foster breastfeeding in the developing world and for undernourished
infants.
He is rightfully considered as the “father of modern breastfeeding.”
This workshop was designed to develop a comprehensive perspective about
available information on the evolution of lactation in most mammalian species,
and to examine in some detail the origin, composition, and functional
characteristics of different nutritional and immunologic components in mammalian
milk and other lactation products. Specifically, the workshop focused on the
following areas: (1) the evolution of mammalian