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907
pages
English
Ebook
2012
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Obtenez un accès à la bibliothèque pour le consulter en ligne En savoir plus
Publié par
Date de parution
29 août 2012
Nombre de lectures
12
EAN13
9780702050299
Langue
English
Poids de l'ouvrage
10 Mo
Mims’ Microbiology makes it easy for you to learn the microbiology and basic immunology concepts you need to know for your courses and USMLE. Using a clinically relevant, systems-based approach, this popular medical textbook accessibly explains the microbiology of the agents that cause diseases and the diseases that affect individual organ systems. With lavish illustrations and straightforward, accessible explanations, Mims’ Microbiology makes this complex subject simple to understand and remember.
- Learn about infections in the context of major body systems and understand why these are environments in which microbes can establish themselves, flourish, and give rise to pathologic changes. This systems-based approach to microbiology employs integrated and case-based teaching that places the "bug parade" into a clinical context.
- Grasp and retain vital concepts easily thanks to a user-friendly color-coded format, succinct text, key concept boxes, and dynamic illustrations.
- Effectively review for problem-based courses with the help of chapter introductions and "Lessons in Microbiology" text boxes that highlight the clinical relevance of the material, offer easy access to key concepts, and provide valuable review tools.
- Approach microbiology by body system or by pathogen through an extensively cross-referenced "Pathogen Review" section.
- Access the complete contents online at studentconsult.com, along with downloadable illustrations…150 multiple choice review questions... "Pathogen Parade"...and many other features to enhance learning and retention.
- Enhance your learning and absorb complex information in an interactive, dynamic way with Pathogen Parade – a quickly searchable online glossary of viruses, bacteria, and fungi.
- Deepen your understanding of epidemiology and the important role it plays in providing evidence-based identification of key risk factors for disease and targets for preventive medicine. A completely re-written chapter on this topic keeps abreast of the very latest findings.
Publié par
Date de parution
29 août 2012
Nombre de lectures
12
EAN13
9780702050299
Langue
English
Poids de l'ouvrage
10 Mo
Mims’ Medical Microbiology
Fifth Edition
Richard V. Goering, BA MSc PhD
Professor and Chair, Department of Medical Microbiology and Immunology, Creighton University Medical Center, School of Medicine, Omaha, Nebraska USA
Hazel M. Dockrell, BA (Mod) PhD
Professor of Immunology, Department of Infectious, and Tropical Diseases, London School of Hygiene & Tropical, Medicine, London, UK
Mark Zuckerman, BSc (Hons) MBBS MRCP MSc FRCPath
Consultant Virologist and Honorary Senior, Lecturer, South London Specialist Virology Centre, King’s College Hospital NHS, Foundation Trust, King’s College London School of Medicine, London, UK
Peter L. Chiodini, BSc MBBS PhD FRCP FRCPath FFTMRCPS (Glas)
Consultant Parasitologist, Hospital for Tropical Diseases, London
Honorary Professor, London School of Hygiene & Tropical, Medicine, London, UK
Ivan M. Roitt, DSc HonFRCP FRCPath FRS,
Hon Director, Middlesex Centre for Investigative, & Diagnostic Oncology, School of Health & Social Sciences, Middlesex University, London, UK
Saunders
Table of Contents
Instructions for online access
Cover image
Title page
Copyright
Preface
Acknowledgements
Contributors
Student Consultants
A contemporary approach to microbiology
Section 1: The adversaries – microbes
Chapter 1: Microbes as parasites
The varieties of microbes
Living inside or outside cells
Systems of classification
Chapter 2: The bacteria
Structure
Nutrition
Growth and division
Gene expression
Survival under adverse conditions
Mobile genetic elements
Mutation and gene transfer
The genomics of medically important bacteria
Chapter 3: The viruses
Infection of host cells
Replication
Outcome of viral infection
Major groups of viruses
Chapter 4: The fungi
Major groups of disease-causing fungi
Chapter 5: The protozoa
Chapter 6: The helminths and arthropods
The helminths
The arthropods
Chapter 7: Prions
‘Rogue protein’ pathogenesis
Development, transmission and diagnosis of prion diseases
Prevention and treatment of prion diseases
Chapter 8: The host–parasite relationship
The normal flora
Symbiotic associations
The characteristics of parasitism
The evolution of parasitism
Section 2: The adversaries–host defences
Chapter 9: The innate defences of the body
Defences against entry into the body
Defences once the microorganism penetrates the body
Elie Metchnikoff (1845–1916)
Oxygen-independent antimicrobial mechanisms
Oxygen-dependent antimicrobial mechanisms
Chapter 10: Adaptive responses provide a ‘quantum leap’ in effective defence
The role of antibodies
The role of T lymphocytes
Extracellular attack on large infectious agents
Local defences at mucosal surfaces
Chapter 11: The cellular basis of adaptive immune responses
B- and T-cell receptors
Clonal expansion of lymphocytes
The role of memory cells
Stimulation of lymphocytes
Cytokines
Regulatory mechanisms
Tolerance mechanisms
Section 3: The conflicts
Chapter 12: Background to the infectious diseases
Host–parasite relationships
Myxomatosis
Causes of infectious diseases
Robert Koch (1843–1910)
The biologic response gradient
Chapter 13: Entry, exit and transmission
Sites of entry
Exit and transmission
Types of transmission between humans
Transmission from animals
Chapter 14: Immune defences in action
Complement
Acute phase proteins and pattern recognition receptors
Fever
Natural killer cells
Phagocytosis
Cytokines
Antibody-mediated immunity
Cell-mediated immunity
Recovery from infection
Chapter 15: Spread and replication
Features of surface and systemic infections
Mechanisms of spread through the body
Genetic determinants of spread and replication
Genetically determined susceptibility to infection
Other factors affecting spread and replication
Chapter 16: Parasite survival strategies and persistent infections
Parasite survival strategies
Trail of illness from a slippery cook
Antigenic variation
Immunosuppression
Persistent infections
Persistence is of survival value for the microbe
Chapter 17: Pathologic consequences of infection
Pathology caused directly by microorganism
Diarrhea
Pathologic activation of natural immune mechanisms
Is it a cold – or is it flu?
Pathologic consequences of the immune response
Skin rashes
Viruses and cancer
The many faces of hepatitis B
Section 4: Clinical manifestation and diagnosis of infections by body system
Introduction
The clinical manifestations of infection
Chapter 18: Upper respiratory tract infections
Rhinitis
Pharyngitis and tonsillitis
Parotitis
Otitis and sinusitis
Acute epiglottitis
Oral cavity infections
Chapter 19: Lower respiratory tract infections
Laryngitis and tracheitis
Diphtheria
Diphtheria toxin
Whooping cough
Acute bronchitis
Acute exacerbations of chronic bronchitis
Bronchiolitis
Respiratory syncytial virus infection
Hantavirus pulmonary syndrome (HPS)
Pneumonia
Bacterial pneumonia
Viral pneumonia
Parainfluenza virus infection
Adenovirus infection
Human metapneumovirus
Human bocavirus
Influenza virus infection
Severe acute respiratory syndrome-associated coronavirus infection
Measles
Cytomegalovirus infection
Tuberculosis
Cystic fibrosis
Lung abscess
Fungal infections
Parasitic infections
Chapter 20: Urinary tract infections
Acquisition and etiology
Pathogenesis
Clinical features and complications
Laboratory diagnosis
Treatment
Prevention
Chapter 21: Sexually transmitted infections
STIs and sexual behaviour
Syphilis
Gonorrhoea
Chlamydial infection
Other causes of inguinal lymphadenopathy
Mycoplasmas and non-gonococcal urethritis
Other causes of vaginitis and urethritis
Genital herpes
Human papillomavirus infection
Human immunodeficiency virus
Opportunist STIs
Arthropod infestations
Chapter 22: Gastrointestinal tract infections
Diarrheal diseases caused by bacterial or viral infection
Food poisoning
Helicobacter pylori and gastric ulcer disease
Parasites and the gastrointestinal tract
Systemic infection initiated in the gastrointestinal tract
Hepatitis A
Hepatitis B
Hepadnaviruses
Chapter 23: Obstetric and perinatal infections
Infections occurring in pregnancy
Congenital infections
Rubella and the fetus
Infections occurring around the time of birth
Chapter 24: Central nervous system infections
Invasion of the central nervous system
The body’s response to invasion
Meningitis
Encephalitis
Neurologic diseases of possible viral Aetiology
Spongiform encephalopathies caused by scrapie-type agents
CNS Disease caused by parasites
Brain abscesses
Tetanus and botulism
Chapter 25: Infections of the eye
Conjunctivitis
Infection of the deeper layers of the eye
Chapter 26: Infections of the skin, soft tissue, muscle and associated systems
Bacterial infections of skin, soft tissue and muscle
Mycobacterial diseases of the skin
Fungal infections of the skin
Parasitic infections of the skin
Mucocutaneous lesions caused by viruses
Smallpox
Measles
Rubella
Other infections producing skin lesions
Kawasaki syndrome
Viral infections of muscle
Parasitic infections of muscle
Joint and bone infections
Infections of the haemopoietic system
Chapter 27: Vector-borne infections
Arbovirus infections
Infections caused by rickettsiae
Borrelia infections
Protozoal infections
Helminth infections
Chapter 28: Multisystem zoonoses
Arenavirus infections
Bolivian haemorrhagic fever: a lesson in ecology
Haemorrhagic fever with renal syndrome (HFRS)
Marburg and ebola haemorrhagic fevers
Crimean–congo haemorrhagic fever, a tick-borne virus
Q Fever
Anthrax
Plague
The Black Death in fourteenth-century England
Yersinia enterocolitica infection
Tularaemia
Pasteurella multocida infection
Leptospirosis
Rat-bite fever
Brucellosis
Helminth infections
Chapter 29: Fever of unknown origin
Definitions of fever of unknown origin
Causes of FUO
Investigation of classic FUO
Treatment of FUO
FUO in specific patient groups
Infective endocarditis
Chapter 30: Infections in the compromised host
The compromised host
Infections of the host with deficient innate immunity due to physical factors
Infections associated with secondary adaptive immunodeficiency
Other important opportunist pathogens
Section 5: Diagnosis and control
Chapter 31: Diagnosis of infection and assessment of host defence
