Mistletoe: From Mythology to Evidence-Based Medicine

Description

0

Informations

• Publié par: S. Karger AG
• Date de parution: 30 avril 2015
• Nombre de lectures: 0
• EAN13: 9783318054453
• Langue: English
• Poids de l'ouvrage: 1 Mo

Extrait

Mistletoe: From Mythology to Evidence-Based Medicine
Translational Research in Biomedicine
Vol. 4
Series Editor
Samuel H.H. Chan Kaohsiung
Associate Editor
Julie Y.H. Chan Kaohsiung
The Chang Gung Medical Foundation is the patron of this book series.
Mistletoe: From Mythology to Evidence-Based Medicine
Volume Editors
Kurt S. Zänker Witten
Srini V. Kaveri Paris/Mumbai
5 figures, 5 in color, 5 tables, 2015
_______________________ Kurt S. Zänker Fakultät für Gesundheit (Department für Humanmedizin) Institut für Immunologie Universität Witten/Herdecke Stockumer Straße 10 D-58453 Witten (Germany)
_______________________ Srini V. Kaveri Centre de Recherche des Cordeliers 15 rue de I'Ecole de Médecine F-75006 Paris (France) and International Associated Laboratory IMPACT Indian council of Medical Research IN-400012 Mumbai (India)
Library of Congress Cataloging-in-Publication Data
Mistletoe (Zänker)
Mistletoe: from mythology to evidence-based medicine/volume editors, Kurt S. Zänker, Srini V. Kaveri.
p. ; cm. -- (Translational research in biomedicine, ISSN 1662-405X ; v. 4)
Includes bibliographical references and indexes.
ISBN 978-3-318-05444-6 (hard cover: alk. paper) -- ISBN 978-3-318-05445-3 (e-ISBN)
I. Zänker, Kurt S., editor. II. Kaveri, Srini V., editor. III. Title. IV. Series: Translational research in biomedicine ; v. 4. 1662-405X
[DNLM: 1. Antineoplastic Agents, Phytogenic--therapeutic use. 2. Viscum album. 3. Anti-Inflammatory Agents--therapeutic use. 4. Fatigue--drug therapy. QZ 267]
RS431.A64
615.7'98--dc23
2015008686
Disclaimer. The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publisher and the editor(s). The appearance of advertisements in the book is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
Drug Dosage. The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any change in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
© Copyright 2015 by S. Karger AG, P.O. Box, CH-4009 Basel (Switzerland)
www.karger.com
Printed in Germany on acid-free and non-aging paper (ISO 9706) by Kraft Druck GmbH, Ettlingen
ISSN 1662-405X
e-ISSN 1662-4068
ISBN 978-3-318-05444-6
e-ISBN 978-3-318-05445-3
Contents
Foreword
Chan, S.H.H. (Kaohsiung)
Preface
Zänker, K.S. (Witten); Kaveri, S.V. (Paris/Mumbai)
Mistletoe through Cultural and Medical History: The All-Healing Plant Proves to Be a Cancer-Specific Remedy
Ramm, H. (Arlesheim)
Chemical Constituents of Viscum album L.: Implications for the Pharmaceutical Preparation of Mistletoe
Urech, K.; Baumgartner, S. (Arlesheim)
The Anti-Cancer Activity of Mistletoe Preparations, as Related to Their Polyphenolic Profiles
Schramm, H.M. (Arlesheim)
From Berlin and Witten to Southampton and Hamburg: 25 Years of Mistletoe Research Cooperation
Schumacher, U.; Pfüller, U. (Hamburg)
Mistletoe Compounds as Anti-Cancer Drugs: Effects and Mechanisms in the Treatment of Glioblastoma
Schötterl, S.; Naumann, U. (Tübingen)
Cancer Surgery and Supportive Mistletoe Therapy: From Scepticism to Randomised Clinical Trials
Galun, D. (Belgrade); Tröger, W. (Freiburg); Milicevic, M. (Belgrade)
Dissecting the Anti-Inflammatory Effects of Viscum album: Inhibition of Cytokine-Induced Expression of Cyclo-Oxygenase-2 and Secretion of Prostaglandin E2
Elluru, S.R. (Linköping); Saha, C.; Hedge, P. (Paris/Compiègne); Friboulet, A. (Compiègne); Bayry, J.; Kaveri, S.V. (Paris)
Dancing with the Devil: Cancer-Related Fatigue, from Inflammation to Treatment Options
Zänker, K.S. (Witten)
Author Index
Subject Index
Foreword
Welcome to Volume Four of Translational Research in Biomedicine , a monograph series dedicated to the dissemination of seminal information in contemporary biomedicine with a translational orientation. This volume marks the second installment of this series under the generous patronage of Chang Gung Medical Foundation of Taiwan. This patronage substantially reduces the increasing financial constraints on scientific publication and allows us to concentrate on publishing text on timely and crucial themes in translational medicine.
This volume is designed to be a key reference on mistletoe. It is intended to reveal all of the conflicts of interest, bias, omissions, and scientific censorship related to the use of mistletoe in oncology. In the spirit of translational medicine, this volume will provide readers with an understanding of the mythology, the culture, the contextuality and the personalized treatment associated with mistletoe, along with fundamental knowledge based on molecular biology, chemistry and biochemistry. Whereas the majority of the literature on plant and natural products has a preferential Eastern flavor, this volume is unique in its own right because it represents our contemporary understanding of mistletoe from a European perspective.
I wish to express my deepest appreciation to Professors Kurt S. Zänker and Srini V. Kaveri, whose patience and sustaining efforts have made this timely volume, or ‘Mistletoe: From Mythology to Evidence-Based Medicine’, a reality. I also wish to acknowledge the capable hands of Thomas Nold and Ricarda Cueni at S. Karger AG during the development and production of this volume. Last but not least, the publication of Translational Research in Biomedicine would not have been possible without the foresight, enthusiasm and whole-hearted support of my dear friend Dr. Thomas Karger.
Samuel H.H. Chan Series Editor
Preface
It is a great honor for us (Kurt S. Zänker (Witten) and Srini V. Kaveri (Paris/Mumbai)) to edit this book on mistletoe, From Mythology to Evidence-Based Medicine , within the book series Translational Research in Biomedicine , published by Karger, as guest editors. With his outstanding reputation in biomedicine and the peer-reviewed approval of the chapters’ content, the Series Editor - Samuel H.H. Chan (Kaohsiung) - is a guarantor of a high international scientific standard for revealing and disseminating experimental and clinical results, embedded into a cultural context, regarding the use of mistletoe preparations in biomedicine.
We have been fortunate to recruit competent scientists who have been working in the field of translational mistletoe research for decades, and we thank them for their distinguished contributions.
Thomas Kuhn [ 1 ] fathered, defined and popularized the concept of ‘paradigm shift’. Currently, a long-standing, historically based view of medicine centered on the intuition, passion and creativity of the individual scientist is being replaced. The replacement is taking place stepwise via a series of peaceful interludes punctuated by biotechnologically and digitally violent revolutions that place value on data collection itself in biomedicine. The 21st century is predestined for a paradigm shift in biomedicine because exciting molecular biology results in biomedical research, the dramatic explosion of (nano-)biotechnology and the digital revolution provide the basis for P4 Medicine in cancer research [ 2 ]. A mandatory prerequisite in personalized medicine - and one of the P4 items - is to collect the greatest quantity of disease-related data sets possible in the hope of better diagnosis and treatment. However, where are the sophisticated algorithms for mining; integrating; modeling; and, at the patient's end, dissecting the large, heterogeneous biological data sets to generate an individualized, actionable and meaningful model to determine what is the best individual therapy at the right time?
At this time, biomedicine is addressing two ideas: i) the idea of applying an object (disease)-orientated collection of computing-powered data sets - from bench to bytes to bedside - and ii) the conservative idea of converting what is perceived into a personal scientific concept to develop hypothesis-driven biomedical starting points for perceiving and reconstructing a patient's individual world for better diagnosis and therapy.
It might sound complex, but behind these two ideas lie some simple concepts. In the future, for successful biomedicine, we need both, and both should provide mutual assistance in order to facilitate biomedical applications of their directives to the well-being of patients.
Biomedicine is not only basic science but also humanities and cultural sciences. The history of medicin