Ophthalmic Radiation Therapy

Description

This publication, a conjoint effort by ocular oncologists and radiation oncologists, comprises ten chapters covering basic and advanced radiation therapy techniques followed by specific indications by location (uveal, retinal, orbital tumors, eyelid and conjunctival tumors) and complications of radiation therapy. A chapter on investigational use of radiation therapy for age-related macular degeneration is also included.

Informations

• Publié par: S. Karger AG
• Date de parution: 28 août 2013
• Nombre de lectures: 0
• EAN13: 9783318024418
• Langue: English
• Poids de l'ouvrage: 2 Mo

Extrait

Ophthalmic Radiation Therapy
Developments in Ophthalmology
Vol. 52
Series Editor
F. Bandello Milan
Ophthalmic Radiation Therapy
Techniques and Applications
Volume Editors
Arun D.Singh Cleveland, Ohio
David E. Pelayes Buenos Aires
Stefan Seregard Stockholm
Roger Macklis Cleveland, Ohio
49 figures, 42 in color, and 7 tables, 2013
_______________________ Arun D. Singh Department of Ophthalmic Oncology Cole Eye Institute Cleveland Clinic Foundation 9500 Euclid Avenue Cleveland, OH 44195 (USA)
_______________________ David E. Pelayes Maimonides University Buenos Aires University Ciudad Autonoma de Buenos Aires Buenos Aires (Argentina)
_______________________ Stefan Seregard St Eriks Eye Hospital Karolinska Institutet Polhemsgatan 50 SE-11 282 Stockholm (Sweden)
_______________________ Roger Macklis Department of Ophthalmic Oncology Cole Eye Institute Cleveland Clinic Foundation 9500 Euclid Avenue Cleveland, OH 44195 (USA)
Library of Congress Cataloging-in-Publication Data
Ophthalmic radiation therapy: techniques and applications / volume editors, Arun D. Singh, David E. Pelayes, Stefan Seregard, Roger Macklis.
p.; cm. –– (Developments in ophthalmology, ISSN 0250-3751 ; vol. 52)
Includes bibliographical references and indexes.
ISBN 978-3-318-02440-1 (hard cover: alk. paper) –– ISBN 978-3-318-02441-8 (electronic version)
I. Singh, Arun D., editor of compilation. II. Pelayes, David E., editor of compilation. III. Seregard, Stefan, editor of compilation. IV. Macklis, Roger M., editor of compilation. V. Series: Developments in ophthalmology; v. 52. 0250-3751
[DNLM: 1. Eye Neoplasms––radiotherapy. 2. Radiotherapy––methods. W1 DE998NG v.52 2013 / WW 149]
RC280.E9
616.99'484––dc23
2013024151
Bibliographic Indices.This publication is listed in bibliographic services, including Current Contents ® and Index Medicus.
Disclaimer. The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publisher and the editor(s). The appearance of advertisements in the book is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
Drug Dosage. The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any change in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
© Copyright 2013 by S. Karger AG, P.O. Box, CH-4009 Basel (Switzerland)
www.karger.com
Printed in Germany on acid-free paper by Kraft Druck GmbH, Ettlingen
ISSN 0250-3751
e-ISSN 1662-2790
ISBN 978-3-318-02440-1
e-ISBN 978-3-318-02441-8
To my parents who educated me beyond their means, my wife Annapurna, and my children, Nakul and Rahul, who make all my efforts worthwhile. (A.D.S.)
To Veronica, love you forever. We will meet again. (D.E.P.)
To Marie, Louise and Caroline for all your love and support. (S.S.)
For our patients and our students who continue to help us to see with clearer eyes. (R.M.)
Contents
List of Contributors
Foreword
Lommatzsch, P.K. (Leipzig)
Preface
Singh, A.D. (Cleveland, Ohio); Pelayes, D.E. (Buenos Aires); Seregard, S. (Stockholm); Macklis, R. (Cleveland, Ohio)
Introduction to Radiotherapy and Standard Teletherapy Techniques
Balagamwala, E.H.; Stockham, A.; Macklis, R.; Singh, A.D. (Cleveland, Ohio)
Teletherapy: Advanced Techniques
Stockham, A.; Balagamwala, E.H.; Singh, A.D.; Macklis, R. (Cleveland, Ohio)
Brachytherapy
Marwaha, G.; Macklis, R.; Singh, A.D.; Wilkinson, A. (Cleveland, Ohio)
Radiation Therapy: Uveal Tumors
Seregard, S. (Stockholm); Pelayes, D.E. (Buenos Aires); Singh, A.D. (Cleveland, Ohio)
Radiation Therapy: Retinal Tumors
Sethi, R.V.; MacDonald, S.M.; Kim, D.Y.; Mukai, S. (Boston, Mass.)
Radiation Therapy: Age-Related Macular Degeneration
Medina Mendez, C.A.; Ehlers, J.P. (Cleveland, Ohio)
Radiation Therapy: Conjunctival and Eyelid Tumors
Aronow, M.E.; Singh, A.D. (Cleveland, Ohio)
Radiation Therapy: Orbital Tumors
Marwaha, G.; Macklis, R.; Singh, A.D. (Cleveland, Ohio)
Radiation Therapy: Anterior Segment Complications
Medina Mendez, C.A.; Singh, A.D. (Cleveland, Ohio)
Radiation Therapy: Posterior Segment Complications
Seregard, S. (Stockholm); Pelayes, D.E. (Buenos Aires); Singh, A.D. (Cleveland, Ohio)
Subject Index
List of Contributors
Mary E. Aronow
Department of Ophthalmic Oncology
Cole Eye Institute
Cleveland Clinic Foundation
9500 Euclid Avenue
Cleveland, OH 44195 (USA)
E-Mail [e-mail]
Ehsan H. Balagamwala
Department of Radiation Oncology
Taussig Cancer Institute
Cleveland, OH 44195 (USA)
E-Mail [e-mail]
Justis P. Ehlers
Vitreoretinal Service
Cleveland Clinic Cole Eye Institute
9500 Euclid Avenue
Cleveland, OH 44195 (USA)
E-Mail [e-mail]
David Y.Kim
Retina Service
Department of Ophthalmology
Massachusetts Eye and Ear Infirmary
Harvard Medical School
Boston, MA 02114 (USA)
E-Mail [e-mail]
Shannon M. MacDonald
Department of Radiation Oncology
Massachusetts General Hospital
Harvard Medical School
Boston, MA 02114 (USA)
E-Mail [e-mail]
Roger Macklis
Department of Ophthalmic Oncology
Cole Eye Institute
Cleveland Clinic Foundation
9500 Euclid Avenue
Cleveland, OH 44195 (USA)
E-Mail [e-mail]
Gaurav Marwaha
Department of Radiation Oncology
Taussig Cancer Institute
Cleveland, OH 44195 (USA)
E-Mail [e-mail]
Carlos A. Medina Mendez
Vitreoretinal Service
Cleveland Clinic Cole Eye Institute
9500 Euclid Avenue
Cleveland, OH 44195 (USA)
E-Mail [e-mail]
Shizuo Mukai
Retina Service
Department of Ophthalmology
Massachusetts Eye and Ear Infirmary
Harvard Medical School
Boston, MA 02114 (USA)
E-Mail [e-mail]
David E. Pelayes
Maimonides University
Buenos Aires University
Ciudad Autonoma de Buenos Aires
Emilio Mitre 477 5 A Caballito
Buenos Aires (Argentina)
E-Mail [e-mail]
Stefan Seregard
St Eriks Eye Hospital
Karolinska Institutet
Polhemsgatan 50
SE-11 282 Stockholm (Sweden)
E-Mail [e-mail]
Roshan V.Sethi
Department of Radiation Oncology
Massachusetts General Hospital
Harvard Medical School
Boston, MA 02114 (USA)
E-Mail [e-mail]
Arun D. Singh
Department of Ophthalmic Oncology
Cole Eye Institute
Cleveland Clinic Foundation
9500 Euclid Avenue
Cleveland, OH 44195 (USA)
E-Mail [e-mail]
Abigail Stockham
Department of Radiation Oncology
Taussig Cancer Institute
Cleveland, OH 44195 (USA)
E-Mail [e-mail]
Allan Wilkinson
Department of Radiation Oncology
Taussig Cancer Institute
Cleveland, OH 44195 (USA)
E-Mail [e-mail]
Foreword
The physicist W.C. Roentgen discovered X-rays in 1895, which were first named after him mainly in the German-speaking literature. The idea of using X-rays in the treatment of malignant diseases was born in the same year when, upon the initiative of a medical student in Chicago named Emil Grubber, X-rays were used to treat a local relapse of breast cancer. Already in 1897, H. Chalupecki published his experimental results about the effect of the new radiation treatment on rabbit eyes. H.L. Hilgartner wrote the first clinical report on the treatment of a bilateral retinoblastoma with X-rays in 1903. At first, there was a general uncertainty about the exact dosage needed so that medical application only slowly gained general acceptance. The introduction of a unit to calculate the absorbed energy within the irradiated tissue – today measured in ‘Grays’ (1 Gy = 1 Ws/kg) – has been a great step forward.
Furthermore, we had to learn that the biological radiation effect is not only dependent on the absorbed energy, but also on the quality of the rays (ionization density, LET), the dose distribution in time (protraction, fractionation), extension of the radiation field as well as some other factors. For this reason, the term relative biological effectiveness was created. The introduction of brachytherapy with radium contact treatment by Mme S. Laborde in Ville