Pain in Psychiatric Disorders

Description

This book offers a series of authoritative reviews on pain in psychiatric disorders written by leading experts. They discuss the complex interplay between pain and psychiatric disorders such as anxiety, depression and borderline personality disorder, as well as neurosteroids, epigenetic mechanisms and TRPV1, with a strong focus on neurobiological mechanisms and current and future therapeutic targets. Special attention is given to the importance of inflammation and the immune system as a common substrate in both pain and psychiatric disorders. The state-of-the-art reviews present both preclinical and clinical research, providing the reader with sound knowledge that provides a basis for further research and clinical practice. Pain in Psychiatric Disorders is of special interest to psychiatrists, neurologists, neuroscientists, pharmacologists and other healthcare professionals treating pain in psychiatric patients, as well as research students with an interest in this field.

Informations

• Publié par: S. Karger AG
• Date de parution: 28 septembre 2015
• Nombre de lectures: 1
• EAN13: 9783318055740
• Langue: English
• Poids de l'ouvrage: 2 Mo

Extrait

Pain in Psychiatric Disorders
Modern Trends in Pharmacopsychiatry
Vol. 30
Series Editor
B.E. Leonard Galway
Pain in Psychiatric Disorders
Volume Editors
David P. Finn Galway
Brian E. Leonard Galway
11 figures and 12 tables, 2015
Modern Trends in Pharmacopsychiatry (Formerly published as ‘Modern Problems in Pharmacopsychiatry’)
_______________________ Prof. David P. Finn Prof. Brian E. Leonard Department of Pharmacology Centre for Pain Research and Galway Neuroscience Centre National University of Ireland Galway (Ireland)
Library of Congress Cataloging-in-Publication Data
Pain in psychiatric disorders / volume editors, David P. Finn, Brian E. Leonard.
p. ; cm. -- (Modern trends in pharmacopsychiatry, ISSN 1662-2685 ; vol. 30)
Includes bibliographical references and index.
ISBN 978-3-318-05573-3 (hard cover: alk. paper) -- ISBN 978-3-318-05574-0 (electronic version)
I. Finn, David P., editor. II. Leonard, B. E., editor. III. Series: Modern trends in pharmacopsychiatry ; v. 30. 1662-2685
[DNLM: 1. Mental Disorders--epidemiology. 2. Pain--epidemiology. 3. Comorbidity. W1 MO168P v.30 2015 / WL 704]
RC455.2.E64
362.2’0422--dc23
2015027765
Bibliographic Indices. This publication is listed in bibliographic services, including Current Contents ® and PubMed/MEDLINE.
Disclaimer. The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publisher and the editor(s). The appearance of advertisements in the book is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
Drug Dosage. The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any change in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
© Copyright 2015 by S. Karger AG, P.O. Box, CH-4009 Basel (Switzerland)
www.karger.com
Printed in Switzerland on acid-free and non-aging paper (ISO 9706) by Kraft Druck GmbH, Ettlingen
ISSN 1662-2685
e-ISSN 1662-4505
ISBN 978-3-318-05573-3
e-ISBN 978-3-318-05574-0
Contents
Preface
Finn, D.P.; Leonard, B.E. (Galway)
Animal Models for the Study of Comorbid Pain and Psychiatric Disorders
Leite-Almeida, H.; Pinto-Ribeiro, F.; Almeida, A. (Braga/Guimarães)
Pain, Depression and Inflammation: Are Interconnected Causative Factors Involved?
Leonard, B.E. (Galway)
Neuroinflammatory Mechanisms Linking Pain and Depression
Burke, N.N.; Finn, D.P.; Roche, M. (Galway)
Cytokines in Neuropathic Pain and Associated Depression
Lees, J.G.; Fivelman, B.; Duffy, S.S.; Makker, P.G.S.; Perera, C.J.; Moalem-Taylor, G. (Sydney, N.S.W.)
Biogenic Amines and the Amino Acids GABA and Glutamate: Relationships with Pain and Depression
Benson, C.; Mifflin, K.; Kerr, B.; Jesudasan, S.J.B.; Dursun, S.; Baker, G. (Edmonton, Alta.)
Supraspinal Transient Receptor Potential Subfamily V Member 1 (TRPV1) in Pain and Psychiatric Disorders
Madasu, M.K.; Roche, M.; Finn, D.P. (Galway)
Involvement of Neuroactive Steroids in Pain, Depression and Anxiety
Mifflin, K.; Benson, C.; Kerr, B. (Edmonton, Alta.); Aricioglu, F.; Cetin, M. (Istanbul); Dursun, S.; Baker, G. (Edmonton, Alta.)
Visceral Pain and Psychiatric Disorders
Felice, V.D.; Moloney, R.D.; Cryan, J.F.; Dinan, T.G.; O'Mahony, S. (Cork)
Genetic and Epigenetic Mechanisms Linking Pain and Psychiatric Disorders
Swiergiel, A.H. (Gdansk/Shreveport, La.); Juszczak, G.R.; Stankiewicz, A.M. (Jastrzebiec)
Emotional and Cognitive Influences on Pain Experience
Peters, M.L. (Maastricht)
Generalized Anxiety Disorder and Pain
Bandelow, B. (Göttingen)
Pain in Borderline Personality Disorder
Schmahl, C.; Baumgärtner, U. (Mannheim)
Author Index
Subject Index
Preface
Despite the widespread interest and concern over the nature and impact of pain on the well-being of patients, research into the causes and treatment of pain has mainly been confined to the provinces of neurology and medicine. And yet, it has been estimated that pain is co-morbid in approximately 50% of patients with major depression, a frequency not dissimilar to that reported for patients with anxiety disorders.
Against this background it is not surprising to find that there is a growing interest in pain and its connection to the pathophysiology of major psychiatric disorders. This is particularly relevant to the management and treatment of psychiatric disorders, as pain complicates the patient's response and recovery.
The purpose of this book is to present an overview of the complex, bidirectional interactions between pain and some major psychiatric disorders. To achieve this, the twelve chapters comprising this volume are divided into four major sections, commencing with the first chapter on animal models for the study of co-morbid pain and psychiatric disorders [ 1 ].
Because of the clinical importance of inflammation in the causes and psychological consequences of pain, the next section [ 2 - 4 ] summarises the role of inflammation that links pain to depression and other psychiatric disorders. The third section [ 5 - 7 ] deals with specific neuromodulatory systems including monoamine and amino acid neurotransmitters, endovanilloids/TRPV1 and neuroactive steroids, focusing on their importance both as key substrates driving pathophysiology and also as potential therapeutic targets in co-morbid pain and psychiatric disorders. The final five chapters [ 8 - 12 ] are primarily concerned with the clinical manifestation of pain in different psychiatric and psychological disorders.
The format of the chapters is similar to the four previous publications in the pharmacopsychiatry series. All the chapters are written by internationally acclaimed experts in pain research and ancillary areas. Every chapter contains key references to the latest research.
The editors are aware that there are many areas of psychiatry in which pain has been implicated but which have not been covered in this book. However, it is anticipated that this volume will provide a stimulus to others to extend the information on the impact of pain in these areas and thereby further open up the possibilities of research and treatment for the benefit of patients and their families.
David P. Finn, Galway Brian E. Leonard, Galway
References
1 Leite-Almeida H, Pinto Ribeiro F, Almeida A: Animal models for the study of comorbid pain and psychiatric disorders; in Finn DP, Leonard BE (eds): Pain in Psychiatric Disorders. Mod Trends Pharmacopsychiatry. Basel, Karger, 2015, vol 30, pp 1-21.
2 Leonard BE: Pain, depression and inflammation: are interconnected causative factors involved?; in Finn DP, Leonard BE (eds): Pain in Psychiatric Disorders. Mod Trends Pharmacopsychiatry. Basel, Karger, 2015, vol 30, pp 22-35.
3 Burke NN, Finn DP, Roche M: Neuroinflammatory mechanisms linking pain and depression; in Finn DP, Leonard BE (eds): Pain in Psychiatric Disorders. Mod Trends Pharmacopsychiatry. Basel, Karger, 2015, vol 30, pp 36-50.
4 Lees JG, Fivelman B, Duffy SS, Makker P, Perera CJ, Moalem-Taylor G: Cytokines in neuropathic pain and associated depression; in Finn DP, Leonard BE (eds): Pain in Psychiatric Disorders. Mod Trends Pharmacopsychiatry. Basel, Karger, 2015, vol 30, pp 51-66.
5 Benson C, Mifflin K, Kerr B, Jesudasan SJB, Dursun S, Baker G: Biogenic amines and the amino acids GABA and glutamate: relationships with pain and depression; in Finn DP, Leonard BE (eds): Pain in Psychiatric Disorders. Mod Trends Pharmacopsychiatry. Basel, Karger, 2015, vol 30, pp 67-79.
6 Madasu MK, Roche M, Finn DP: Supraspinal transient receptor potential subfamily V member 1 in pain and psychiatric disorders; in Finn DP, Leonard BE (eds): Pain in Psychiatric Disorders. Mod Trends Pharmacopsychiatry. Basel, Karger, 2015, vol 30, pp 80-93.
7 Mifflin K, Benson C, Kerr B, Aricioglu F, Cetin M, Dursun S, Baker G: Involvement of neuroactive steroids in pain, depression and anxiety; in Finn DP, Leonard BE (eds): Pain in Psychiatric Disorders. Mod Trends Pharmacopsychiatry. Basel, Karger, 2015, vol 30, pp 94-102.
8 Felice VD, Moloney RD, Cryan JF, Dinan TG, O'Mahony SM: Visceral pain and psychiatric disorders; in Finn DP, Leonard BE (eds): Pain in Psychiatric Disorders. Mod Trends Pharmacopsychiatry. Basel, Karger, 2015, vol 30, pp 103-119.
9 Swiergiel AH, Juszczak GR, Stankiewicz A: Genetic and epigenetic mechanisms linking pain and psychiatric disorders; in Finn DP, Leonard BE (eds): Pain in Psychiatric Disorders. Mod Trends Pharmacopsychiatry. Basel, Karger, 2015,