Pancreatic Neoplasms, An Issue of Surgical Oncology Clinics of North America

Nipun Merchant

Description

This issue of Surgical Oncology Clinics of North America, guest edited by Nipun Merchant, MD, is devoted to Pancreatic Neoplasms. Dr. Merchant has assembled expert authors to review the following topics: Molecular and Genetic Basis of Pancreatic Carcinogenesis: Which Concepts May Be Clinically Relevant?; Role Of EUS and ERCP In The Clinical Assessment Of Pancreatic Neoplasms; Optimal Imaging Modalities For The Diagnosis and Staging Of Periampullary Lesions; Advances in the Surgical Management of Resectable and Borderline Resectable Pancreatic Cancer; Minimally Invasive Approaches to Pancreatic Surgery; Adjuvant and Neoadjuvant Therapy for Pancreatic Cancer; Palliative Management of Unresectable Pancreatic Cancer; Spectrum and Classification of Cystic Lesions of the Pancreas; Therapeutic Approach to Cystic Neoplasms of the Pancreas; Clinical Presentation and Management of Pancreatic Neuroendocrine Tumors; State-of-the-Art Imaging of Pancreatic Neuroendocrine Tumors; Surgical Approaches to Pancreatic Neuroendocrine Tumors; and Medical Management of Pancreatic Neuroendocrine Tumors: Current and Future Therapy.

Sujets

• Médecine
• Médecine Générale
• Surgery
• Medical

Informations

• Publié par: Elsevier
• Date de parution: 20 avril 2016
• Nombre de lectures: 0
• EAN13: 9780323417761
• Langue: English
• Poids de l'ouvrage: 3 Mo

Extrait

Pancreatic Neoplasms
Editor
Nipun B. Merchant, MD
Sylvester Comprehensive Cancer Center, University of Miami Medical Center, Miami, FL, USA

Consulting Editor
Nicholas J. Petrelli

Clinics Review Articles

www.surgonc.theclinics.com

April 2016 Volume 25 Number 2
Table of Contents
Cover image
Title page
Copyright
Contributors
Consulting Editor
Editor
Authors
Forthcoming Issues
Forthcoming Issues
Recent Issues
Foreword. Pancreatic Neoplasms
Preface. Eat When You Can, Sleep When You Can, and Don t Mess with the Pancreas
Molecular and Genetic Basis of Pancreatic Carcinogenesis: Which Concepts May be Clinically Relevant?
Key points
Multistep progression of pancreatic ductal adenocarcinoma
KRAS
Telomere shortening
CDKN2A
TP53
SMAD4
Clinical relevance of core pancreatic ductal adenocarcinoma mutations
Germline variants
Core signaling pathways in pancreatic cancer
Using genomic sequencing to guide therapy
Summary
Acknowledgments
References
Optimal Imaging Modalities for the Diagnosis and Staging of Periampullary Masses
Key points
Introduction
Periampullary masses
Cross-sectional imaging techniques
Imaging findings
Structured reporting
Summary
References
Role of Endoscopic Ultrasonography and Endoscopic Retrograde Cholangiopancreatography in the Clinical Assessment of Pancreatic Neoplasms
Key points
Endoscopic ultrasonography in pancreatic neoplasms
Endoscopic retrograde cholangiopancreatography in pancreatic neoplasms
Summary
References
Minimally Invasive Approaches to Pancreatic Surgery
Key points
Introduction
Laparoscopic distal pancreatectomy
Robot-assisted distal pancreatectomy
Laparoscopic pancreaticoduodenectomy
Robot-assisted pancreaticoduodenectomy
References
Advances in the Surgical Management of Resectable and Borderline Resectable Pancreas Cancer
Key points
Introduction
Determining resectability
Diagnostic workup
Vascular resection during pancreaticoduodenectomy
Aberrant vascular anatomy and celiac stenosis
Lymphadenectomy in pancreatic cancer
Pylorus-sparing versus standard pancreaticoduodenectomy
The role for minimally invasive surgery
Complications following pancreaticoduodenectomy
Palliative options
Summary
References
Adjuvant and Neoadjuvant Therapy for Pancreatic Cancer
Key points
Introduction
Historic adjuvant systemic trials
Current and future areas of investigation in adjuvant therapy
Neoadjuvant therapy: an emerging paradigm in pancreas adenocarcinoma
Neoadjuvant radiation therapy trials
Gemcitabine-based neoadjuvant systemic therapy trials
Neoadjuvant therapy with FOLFIRINOX
Current and emerging areas of neoadjuvant investigation
Immunotherapy trials
Summary
References
Palliative Management of Unresectable Pancreas Cancer
Key points
Background
Current treatment of unresectable pancreatic cancer
Palliative resection
Biliary decompression
Gastric decompression
Pain control
Summary
References
Spectrum and Classification of Cystic Neoplasms of the Pancreas
Key points
Introduction
Mucinous cystic neoplasms
Serous cystic neoplasm
Cystic pancreatic endocrine neoplasms
Solid pseudopapillary neoplasm
Intraductal papillary mucinous neoplasm
Summary
References
Therapeutic Approach to Cystic Neoplasms of the Pancreas
Key points
Introduction
Serous cystadenoma
Mucinous cystic neoplasms (cystadenoma and cystadenocarcinoma)
Intraductal papillary mucinous neoplasms of the pancreas
Less common cystic neoplasms of the pancreas
Summary
References
Clinical Presentation and Diagnosis of Pancreatic Neuroendocrine Tumors
Key points
Epidemiology
Clinical behaviors and diagnosis of specific pancreatic neuroendocrine tumors
Tumor behavior and prognosis
Summary
References
State-of-the-art Imaging of Pancreatic Neuroendocrine Tumors
Key points
Introduction
Imaging techniques
Imaging findings
Nonfunctioning pancreatic neuroendocrine tumors
Poorly differentiated pancreatic endocrine tumors
Staging
Summary
References
Surgical Management of Pancreatic Neuroendocrine Tumors
Key points
Introduction
General features of pancreatic neuroendocrine tumors
Surgical management of localized pancreatic neuroendocrine tumors
Management of neuroendocrine liver metastases
Role of liver transplantation in treatment of neuroendocrine liver metastases
Summary
References
Medical Management of Pancreatic Neuroendocrine Tumors: Current and Future Therapy
Key points
Introduction
Classification of pancreatic neuroendocrine tumors
Genetic basis of neuroendocrine tumors
Systemic treatment of advanced pancreatic neuroendocrine tumors
Targeted therapy
Future directions
Summary
References
Copyright
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SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA Volume 25, Number 2
April 2016 ISSN 1055-3207, ISBN-13: 978-0-323-41775-4
Editor: John Vassallo ( [e-mail] )
Developmental Editor: Meredith Clinton
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