Pediatric Endocrinology and Diabetes, An Issue of Pediatric Clinics of North America

Denis Daneman

Description

The Guest Editors have compiled a comprehensive issue that includes both disorders of endocrinology as well as diabetes. Authors have addressed the following clinical topics: disorders of menstruation, thyroid function; gender dysphoria; hypoglycemia in the nondiabetic child; preventing DKA; short- and long-term outcomes in diabetes, and whole genome sequencing in endocrinology. These topics represent the current knowedge in the field, and pediatricians will have the most updated clinical information as they evaluate and treat children with diabetes or endocrinology disorders.

Sujets

• Medical
• Médecine
• Pediatrics

Informations

• Publié par: Elsevier
• Date de parution: 12 novembre 2015
• Nombre de lectures: 0
• EAN13: 9780323393515
• Langue: English
• Poids de l'ouvrage: 2 Mo

Extrait

Clinics Review Articles Pediatric Clinics of North America
Pediatric Endocrinology and Diabetes

Denis Daneman, MBBCh, FRCPC
Department of Paediatrics, University of Toronto, The Hospital for Sick Children, R.S. McLaughlin Foundation Chair, in Paediatrics, Toronto, Canada

Mark R. Palmert, MD, PhD
Division of Endocrinology, The Hospital for Sick Children, Departments of Paediatrics and Physiology, University of Toronto, Toronto, Ontario, Canada
ISSN  0031-3955 Volume 62 • Number 4 • August 2015
Elsevier
Table of Contents
Cover image
Title page
Copyright
CME Accreditation Page
Target Audience
Learning Objectives
Accreditation
Disclosure of Conflicts of Interest
Unapproved/Off-Label Use Disclosure
To Enroll
Method of Participation
CME Inquiries/Special Needs
Contributors
Consulting Editor
Editors
Authors
Forthcoming Issues
Forthcoming Issues
Recent Issues
Foreword: Pediatric Endocrinology and Diabetes
Preface: Pediatric Diabetes and Endocrinology
Childhood Obesity
Key points
Background
Etiology/Risk factors
Comorbidities/Consequences of childhood obesity
Assessment/Screening
Treatment
Prevention
Future directions
The Child with Multiple Fractures, What Next?
Key points
The pattern of fractures in childhood
Determinants of fracture risk
Conditions associated with bone fragility
Approach to the child with multiple fractures
Summary
Preventing Diabetic Ketoacidosis
Key points
Introduction
Epidemiology and causes of diabetic ketoacidosis
Diabetic ketoacidosis at diagnosis
Diabetic ketoacidosis in established type 1 diabetes mellitus
Summary
The Impact of Technology on Current Diabetes Management
Key points
Introduction
New insulins
Rapid-acting analogues
Long-acting insulins
Continuous subcutaneous insulin infusion
Continuous monitoring systems and closed-loop therapy
Summary
Long-term Outcomes in Youths with Diabetes Mellitus
Key points
Overview of diabetes-related complications
Short-term complications of type 1 diabetes
Long-term complications of type 1 diabetes
Screening for diabetes complications in youths
Comparison of outcomes in the pre– and post–diabetes control and complications trial eras
Complications in youths with type 2 diabetes mellitus
The brain and cognitive effects of diabetes
The Impact of Diabetes on Brain Function in Childhood and Adolescence
Key points
Introduction
The evidence for type 1 diabetes–related brain injury
Mechanisms of injury
Implications for management of type 1 diabetes
Summary
Interpreting Minor Variations in Thyroid Function or Echostructure
Key points
Minor variations in thyroid function
Minor variations in thyroid echostructure
Summary
Disorders of Menstruation in Adolescent Girls
Key points
Introduction
The common presenting complaints
What is normal, and the maturation of the hypothalamic-pituitary-ovarian axis
Abnormal uterine bleeding: the generic assessment
Abnormal uterine bleeding: causes worthy of particular mention
Pregnancy
Summary
Short Stature
Key points
Introduction
Is short stature an impediment to psychosocial adjustment?
Does changing height matter?
Why do beliefs and stereotypes persist despite contradictory evidence?
Summary and recommendations
Approach to the Infant with a Suspected Disorder of Sex Development
Key points
Introduction
Sexual differentiation
Nomenclature
Care of the infant
History
Physical examination
Investigations
Interpretation of results
46XX disorders of sex development
Sex chromosome disorders of sex development
Sex of rearing decisions
Normal variants that can seem to be a disorder of sex development
Current controversies
Psychosocial care and communication with the parents and family
Summary
Gender Variance and Dysphoria in Children and Adolescents
Key points
Terminology
Epidemiology
Gender identity development
Issues faced by gender variant and transgender youth and their families
Evolving approach to prepubertal gender variant children
Approach to pubertal youth
Puberty suppression
Puberty-suppressing medications
Timing of puberty suppression
Monitoring and side effects
Physiologic and medical outcomes
Psychological and mental health outcomes
Cross-sex hormones
Evaluating readiness
Medical evaluation
Timing of cross-sex hormones
Side effects of cross-sex hormones
Progesterone
Cross-sex hormones and gender-affirming surgery
Summary
Hyperinsulinemic Hypoglycemia
Key points
Introduction
Definition of hypoglycemia
Metabolic and endocrine changes in glucose physiology at the time of birth
Mechanisms of insulin secretion
Types of hyperinsulinemic hypoglycemia
Clinical characteristics
Biochemical features
Importance of genetic testing for congenital hyperinsulinemic hypoglycemia
Role of the 18F-l-3,4-dihydroxyphenylalanine-PET/computed tomography in the management of congenital hyperinsulinemic hypoglycemia
Treatment
Summary
Genome, Exome, and Targeted Next-Generation Sequencing in Neonatal Diabetes
Key points
Introduction to neonatal diabetes
Introduction to next-generation sequencing
Targeted next-generation sequencing
Exome sequencing
Genome sequencing
Concluding remarks
Index
Copyright
ELSEVIER
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THE PEDIATRIC CLINICS OF NORTH AMERICA Volume 62, Number 4
August 2015 ISSN 0031-3955, ISBN-13: 978-0-323-39350-8
Editor: Kerry Holland
Developmental Editor: Casey Jackson
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