PET in the Aging Brain, An Issue of PET Clinics

Andrew B. Newberg, Alavi Abass

Description

PET imaging has shown its value in diagnosing diseases affecting older people. Most significantly this has been with regard to the diagnosis of Alzheimer’s disease and other forms of dementia. Parkinson’s disease is another condition in which PET has proved valuable. This issue also included articles on the uses of PET for diagnosing cerebrovascular disease and for assessing neuroplasticity.

Sujets

• Nuclear Medicine
• Radiotherapy
• Medical
• Médecine
• Radiology

Informations

• Publié par: Saunders
• Date de parution: 22 juin 2010
• Nombre de lectures: 0
• EAN13: 9781455700554
• Langue: English
• Poids de l'ouvrage: 3 Mo

Extrait

PET Clinics
PET in the Aging Brain

Andrew B. Newberg, MD
Division of Nuclear Medicine, Hospital of the University of Pennsylvania, 110 Donner Building, 3400 Spruce Street, Philadelphia, PA 19104, USA

Abass Alavi, MD
Division of Nuclear Medicine, Hospital of the University of Pennsylvania, 110 Donner Building, 3400 Spruce Street, Philadelphia, PA 19104, USA
ISSN  1556-8598 Volume 5 • Number 1 • January 2010
Table of Contents
Cover image
Title page
Contributors
PET Clinics
CME Accreditation Page and Author Disclosure
Goal Statement
Accreditation
Faculty Disclosure/Conflict of Interest
To Enroll
Preface
Normal Patterns and Variants in PET Brain Imaging
Other biochemical changes in normal aging
Evaluation of Early Dementia (Mild Cognitive Impairment)
“At risk” populations
Limitations
Amyloid PET Ligands for Dementia
Alzheimer’s disease and other dementias
Amyloid ligands
Amyloid imaging in dementia
Amyloid imaging and other markers of disease
Specific biomarkers of disease
Summary
18F-Fluorodeoxyglucose PET in the Evaluation of Parkinson Disease
Metabolic networks in parkinsonism
SPECT and PET in Atypical Parkinsonism
The spectrum of movement disorders
Dopaminergic imaging in the diagnosis of parkinsonism and related disorders
Nondopaminergic imaging in the differential diagnosis of movement disorders
Identifying new targets and imaging biomarkers in Parkinson spectrum disorders
Summary
18F-AV-133: A Selective VMAT2-binding Radiopharmaceutical for PET Imaging of Dopaminergic Neurons
Approaches to DA neuron imaging
VMAT2 as PET imaging target
PET in Cerebrovascular Disease
Normal cerebral hemodynamics and energy metabolism
Cerebrovascular control
Hemodynamic effects of arterial occlusive disease
Evolution of acute infarction
Identification of preventable infarction
Carotid artery atherosclerosis
Remote metabolic effects of cerebral infarction
Vascular dementia
Intracerebral hemorrhage
Aneurysmal subarachnoid hemorrhage
Summary
Imaging Pathophysiology and Neuroplasticity After Stroke
Task-dependent cortical activation studies
Index
Contributors

CONSULTING EDITOR
ABASS ALAVI, MD, MD (Hon), PhD (Hon),
DSc (Hon)
Director of Research Education, Nuclear
Medicine Section, Department of Radiology,
Hospital of the University of Pennsylvania,
Philadelphia, Pennsylvania

GUEST EDITORS
ANDREW B. NEWBERG, MD
Associate Professor, Division of Nuclear
Medicine, Department of Radiology, University
of Pennsylvania School of Medicine,
Philadelphia, Pennsylvania
ABASS ALAVI, MD, MD (Hon), PhD (Hon),
DSc (Hon)
Director of Research Education, Nuclear
Medicine Section, Department of Radiology,
Hospital of the University of Pennsylvania,
Philadelphia, Pennsylvania

AUTHORS
ABASS ALAVI, MD, MD (Hon), PhD (Hon),
DSc (Hon)
Director of Research Education, Nuclear
Medicine Section, Department of Radiology,
Hospital of the University of Pennsylvania,
Philadelphia, Pennsylvania
V. BERTI, MD
Department of Psychiatry, Center for Brain
Health, Silberstein Alzheimer s Institute, Center
of Excellence on Brain Aging, NYU Langone
Medical Center, New York, New York;
Department of Clinical Pathophysiology,
Nuclear Medicine Unit, University of Florence,
Florence, Italy
ALAN P. CARPENTER, PhD, JD
Avid Radiopharmaceuticals Inc, Philadelphia,
Pennsylvania
CHRISTOPHER M. CLARK, MD
Avid Radiopharmaceuticals Inc; Departments
of Neurology and Radiology, University of
Pennsylvania, Philadelphia, Pennsylvania
M.J. DE LEON, EdD
Department of Psychiatry, Center for Brain
Health, Silberstein Alzheimer s Institute,
Center of Excellence on Brain Aging,
NYU Langone Medical Center, New York,
New York; Nathan Kline Institute,
Orangeburg, New York
S. DE SANTI, PhD
Department of Psychiatry, Center for Brain
Health, Silberstein Alzheimer s Institute, Center
of Excellence on Brain Aging, NYU Langone
Medical Center, New York, New York
DAVID EIDELBERG, MD
Departments of Neurology and Medicine,
North Shore University Hospital, Manhasset,
New York
L. GLODZIK, MD, PhD
Department of Psychiatry, Center for Brain
Health, Silberstein Alzheimer s Institute, Center
of Excellence on Brain Aging, NYU Langone
Medical Center, New York, New York
FRANZ F. HEFTI, PhD
Avid Radiopharmaceuticals Inc, Philadelphia,
Pennsylvania
MICHAEL R. KILBOURN, PhD
Professor, Department of Radiology,
University of Michigan, Ann Arbor, Michigan
HANK F. KUNG, PhD
Professor, Department of Radiology, University
of Pennsylvania, Philadelphia, Pennsylvania
Y. LI, MD
Department of Psychiatry, Center for Brain
Health, Silberstein Alzheimer s Institute, Center
of Excellence on Brain Aging, NYU Langone
Medical Center, New York, New York
L. MOSCONI, PhD
Department of Psychiatry, Center for Brain
Health, Silberstein Alzheimer s Institute, Center
of Excellence on Brain Aging, NYU Langone
Medical Center, New York, New York
JAMES M. MOUNTZ, MD, PhD
Professor of Radiology; Chief of Nuclear
Medicine and Director NeuroNuclear Medicine,
University of Pittsburgh Medical Center, PET
Facility, Pittsburgh, Pennsylvania
ANDREW B. NEWBERG, MD
Associate Professor, Division of Nuclear
Medicine, Department of Radiology, University
of Pennsylvania School of Medicine,
Philadelphia, Pennsylvania
R.S. OSORIO, MD
Department of Psychiatry, Center for Brain
Health; Departments of Pathology and
Psychiatry, Alzheimer s Disease Center,
Silberstein Alzheimer s Institute, Center of
Excellence on Brain Aging, NYU Langone
Medical Center, New York, New York;
Alzheimer s Disease Research Unit, CIEN
Foundation-Reina Sofia Foundation,
Carlos III Institute of Health, Madrid, Spain
KATHLEEN L. POSTON, MD, MS
Department of Neurology and Neurological
Sciences, Stanford University Medical Center,
Stanford, California
WILLIAM J. POWERS, MD
H. Houston Merritt Distinguished Professor
and Chair, Department of Neurology,
University of North Carolina School of
Medicine, Chapel Hill, North California
CHRISTOPHER C. ROWE, MD
Director, Department of Nuclear Medicine and
Centre for PET, Austin Health; Professor,
Department of Medicine, Austin Health,
Victoria, Australia
JOHN P. SEIBYL, MD
Senior Scientist, Institute for
Neurodegenerative Disorders, Molecular
Neuroimaging, LLC, Yale University
School of Medicine, New Haven,
Connecticut
DANIEL M. SKOVRONSKY, MD, PhD
Avid Radiopharmaceuticals Inc; Department
of Radiology, University of Pennsylvania,
Philadelphia, Pennsylvania
VICTOR L. VILLEMAGNE, MD
Senior Research Fellow, Department
of Nuclear Medicine and Centre for PET,
Austin Health; Honorary Senior Research
Officer, The Mental Health Research Institute
of Victoria; Senior Research Fellow,
Department of Medicine, Austin Health,
Victoria, Australia
ALLYSON R. ZAZULIA, MD
Associate Professor, Departments
of Neurology and Radiology, Washington
University School of Medicine, St Louis,
Missouri
PET Clinics
Forthcoming Issues
April 2010
PET in CNS Disease
Andrew Newberg, MD,
Guest Editor

July 2010
Musculoskeletal PET
Roland Hustinx, MD,
Guest Editor

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CME Accreditation Page and Author Disclosure


Goal Statement
The goal of the PET Clinics is to keep practicing radiologists and radiology residents up to date with current clinical practice in positron emission tomography by providing timely articles reviewing the state of the art in patient care.

Accreditation
PET Clinics is planned and implemented in accordance with the Essential Areas and Policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the University of Virginia School of Medicine and Elsevier. The University of Virginia School of Medicine is accredited by the ACCME to provide continuing medical education for physicians.
The University of Virginia School of Medicine designates this educational activity for a maximum of 15 AMA PRA Category 1 Credits™ for each issue, 60 credits per year. Physicians should only claim credit commensurate with the extent of their participation in the activity.
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