SickKids Handbook of Pediatric Thrombosis and Hemostasis

Description

A Karger 'Publishing Highlights 1890–2015' title
This handbook takes the reader through the entire field of pediatric thrombosis and hemostasis. An introductory section concisely explains the complex pathophysiology of hemostasis and thrombosis. The chapters that follow include practical, evidence-based information on the diagnosis and management of inherited and acquired bleeding disorders and thrombotic events of the venous, arterial, cardiac and central nervous systems that affect children. Special features include practical clinical algorithms and appendices that cite normal laboratory reference ranges, as well as recommended dosages of blood products and major hemostatic agents. A stand-alone chapter is dedicated to developmental hemostasis and bleeding in the neonate. A chapter on antithrombotic therapy in children gives succinct information on the old and new anticoagulants, antiplatelet drugs and thrombolytic agents. Written and reviewed by international experts in the field, this handbook is intended for health care professionals involved in the assessment and care of children with inherited and acquired bleeding and clotting disorders, including general and specialist pediatricians (in particular intensivists, neonatologists, cardiologists/cardiac surgeons, rheumatologists and nephrologists), hematologists/oncologists (pediatric and adult), as well as medical trainees, nurses, nurse practitioners and pharmacists.

Informations

• Publié par: S. Karger AG
• Date de parution: 20 juin 2013
• Nombre de lectures: 0
• EAN13: 9783318021981
• Langue: English
• Poids de l'ouvrage: 3 Mo

Extrait

SickKids Handbook of Pediatric Thrombosis and Hemostasis
SickKids Handbook of Pediatric Thrombosis and Hemostasis
Editors
Victor S. Blanchette , Toronto, Ont., Canada
Vicky R. Breakey , Hamilton, Ont., Canada
Shoshana Revel-Vilk , Jerusalem, Israel
23 figures, 9 in color, 9 algorithms, and 59 tables, 2013
We dedicate this book in memory of Maureen Andrew, a skilled clinician, valued mentor, respected researcher and a pioneer in pediatric thrombosis. For many of the authors she was a colleague and friend. For those who didn't know her personally, she remains an inspiration.

‘The great physician is one who not only uses what is known but also recognizes what is not known and what is needed in her patients. Maureen was a great physician.’
A. Zipursky, 2001.
Victor S. Blanchette, MA, MB BChir(Cantab), FRCP(C), FRCP
Professor of Pediatrics, University of Toronto
Medical Director, Pediatric Thrombosis and Hemostasis Program
Division of Hematology/Oncology, The Hospital for Sick Children
Toronto, Ont., Canada
Vicky R. Breakey, MD, MEd, FRCPC
Pediatric Hematologist/Oncologist, Assistant Professor
Division of Pediatric Hematology/Oncology, McMaster Children's Hospital
McMaster University
Hamilton, Ont., Canada
Shoshana Revel-Vilk, MD, MSc
Director, Pediatric Hematology Center
Senior Lecturer of Pediatrics, Hadassah Hebrew-University Medical School
Department of Pediatric Hematology/Oncology, Hadassah Hebrew-University Hospital
Jerusalem, Israel
Library of Congress Cataloging-in-Publication Data
SickKids handbook of pediatric thrombosis and hemostasis / editors, Victor S. Blanchette, Vicky R. Breakey, Shoshana Revel-Vilk.
p.; cm.
Pediatric thrombosis and hemostasis
Includes bibliographical references and index.
ISBN 978-3-318-02197-4 (hard cover: alk. paper) –– ISBN 978-3-318-02198-1 (e-ISBN)
I. Blanchette, Victor S. II. Breakey, Vicky R. III. Revel-Vilk, Shoshana. IV. Title: Pediatric thrombosis and hemostasis.
[DNLM: 1. Hematologic Diseases. 2. Anticoagulants. 3. Child. 4. Hemostasis. 5. Infant. 6. Thrombosis. WS 300]
RJ270
618.92'157––dc23
2013009736
Bibliographic Indices. This publication is listed in bibliographic services.
Disclaimer. The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publisher and the editor(s). The appearance of advertisements in the book is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
Drug Dosage. The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any change in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
© Copyright 2013 by S. Karger AG, P.O. Box, CH-4009 Basel (Switzerland)
www.karger.com
Printed in Germany on acid-free and non-aging paper (ISO 9706) by Bosch Druck, Ergolding
ISBN 978-3-318-02197-4
e-ISBN 978-3-318-02198-1
Contents
Contributors
Preface
Chapter  1  Pediatric Thrombosis and Hemostasis: A Historical Perspective
V.R. Breakey, V.S. Blanchette
Thrombosis in Childhood
Hemostatic Disorders in Children: The Evolution of Hemophilia Care
The Future of Pediatric Thrombosis and Hemostasis
Acknowledgment
References
Abbreviations
Chapter  2  Primary and Secondary Hemostasis, Regulators of Coagulation, and Fibrinolysis: Understanding the Basics
S. Revel-Vilk, M.L. Rand, S.J. Israels
Introduction
Primary Hemostasis
Secondary Hemostasis
Regulators of Coagulation
Fibrinolysis
Conclusion
References
Abbreviations
Chapter  3  An Approach to the Bleeding Child
S. Revel-Vilk, M.L. Rand, S.J. Israels
Introduction
History
Physical Examination
Laboratory Investigations
References
Abbreviations
Chapter  4  Bleeding in the Neonate
L. Avila, D. Barnard
Developmental Hemostasis
Platelet Disorders: Neonatal Thrombocytopenia
Recommendations for Platelet Transfusions
Coagulation Factor Deficiencies
Combined Disorders
Diagnostic Algorithm: Approach to Bleeding in the Neonate
Acknowledgment
References
Abbreviations
Chapter  5  Platelet Disorders in Children
V. van Eimeren, W.H.A. Kahr
Introduction
Diagnosis of Platelet Disorders
Thrombocytopenia
Platelet Function Defects
Conclusion
Acknowledgment
References
Abbreviations
Chapter  6  Managing Hemophilia in Children and Adolescents
J.D. Robertson, J.A. Curtin, V.S. Blanchette
Introduction
General Management Principles
Inhibitors
Management of Bleeding Episodes
Specific Sites of Bleeding
Management of Surgery and Other Invasive Procedures
Chronic Complications of Hemophilia
Management of the Newborn with Suspected or Possible Hemophilia
Conclusion
Acknowledgment
References
Abbreviations
Chapter  7  von Willebrand Disease in Children
V.R. Breakey, M. Carcao
Introduction
Pathophysiology of von Willebrand Disease
Clinical Presentation
Diagnosis
Management
Conclusion
Acknowledgment
References
Abbreviations
Chapter  8  Rare Congenital Factor Deficiencies in Childhood
F. Xavier, V.S. Blanchette
Introduction
Factor XI Deficiency
Factor VII Deficiency
Fibrinogen Disorders
Factor XIII Deficiency
Other Rare Inherited Coagulation Disorders
Conclusion
Acknowledgment
References
Abbreviations
Chapter  9  Acquired Bleeding Disorders in Children
R. Kumar, M.Steele
Introduction
Disseminated Intravascular Coagulation
Thrombotic Microangiopathic Disorders
Hemolytic Uremic Syndrome
Thrombotic Thrombocytopenic Purpura
Coagulopathy of Chronic Liver Disease
Bleeding in Chronic Renal Failure
Acquired Hemophilia
Acquired von Willebrand Syndrome
Hypoprothrombinemia-Lupus Anticoagulant Syndrome
Acquired Inhibitors after Bovine Thrombin Exposure
Conclusion
Acknowledgment
References
Abbreviations
Chapter  10  A Diagnostic Approach to a Child with Thrombosis
M. Rizzi, C. Barnes
Introduction
History
Physical Examination
Diagnostic Imaging
Laboratory Investigations
Laboratory Thrombophilia
Anatomical Thrombophilia
Conclusion
Acknowledgment
References
Abbreviations
Chapter  11  Venous Thrombosis
V.E. Price, L.R. Brandão, S.Williams
Introduction
Deep Vein Thrombosis
Catheter-Related Thrombosis
Pulmonary Embolism
Venous Thrombosis in Neonates
Venous Thrombosis in Cancer Patients
Inferior Vena Cava Filter
Venous Stents
Post-Thrombotic Syndrome
Conclusion
Acknowledgment
References
Abbreviations
Chapter  12  Arterial Thrombosis
S. Revel-Vilk, M. Albisetti, M.P. Massicotte
Introduction
Arterial Catheter-Related Thrombosis
Umbilical Artery Catheter-Related Thrombosis
Aortic Thrombosis
Arterial Stents – Non-Cardiac, Non-CNS
Non-Catheter-Related Arterial Thrombosis
Complications of Arterial Thrombosis
Conclusion
Acknowledgment
References
Abbreviations
Chapter  13  Thromboembolic Events at Specific Organ Sites
V. Labarque, A.K.C. Chan, S. Williams
Introduction
Kidney-Related Thromboembolic Events
Liver-Related Thromboembolic Events
Mesenteric Vascular Thrombosis
Splenic Vein Thrombosis
Long-Term Complications
Conclusion
Acknowledgment
References
Abbreviations
Chapter  14  Pediatric Stroke
A. Andrade, R. Ichord, N. Dlamini, S. Williams, G. deVeber
Introduction
Arterial Ischemic Stroke
Cerebral Sinovenous Thrombosis
Transient Ischemic Attack
Conclusion
Acknowledgment
References
Abbreviations
Chapter  15  Bleeding and Clotting in Children with Cardiac Disease
Y. Diab, B.W. McCrindle, L.R. Brandão
Introduction
Mechanical Circulatory Support for Pediatric Cardiac Disease
Cardiac Conduits, Shunts and St