The Na+, K+ Pumps Keep Us Going

Torben Clausen

Description

Every second throughout life, billions of sodium-potassium pumps enable the human muscle cells to function. The pump is an enzyme found in the plasma membrane of all animal cells and is an important example of active transport. The Na+, K+-pumps keep us going by pumping sodium out of cells while pumping potassium into cells and without them, we would not survive. Addressed to specialists in the field of biomedicine, the author presents a thorough overview of his scientific results over more than 40 years. The book is richly illustrated and seeks to explain how a single molecule creates the required conditions for our muscles to work.

Sujets

• Médecine
• Médecine Générale
• Medical

Informations

• Publié par: Aarhus University Press
• Date de parution: 31 décembre 2016
• Nombre de lectures: 0
• EAN13: 9788771842470
• Langue: English
• Poids de l'ouvrage: 6 Mo

Extrait

THE TORBEN CLAUSEN + + Na,K PUMPS KEEP US GOING

+ Skeeta musce K poo

2600 mmoes

+ K

+ Na

+ K channes

+ Extraceuar K poo

56 mmoes

+ + Na , K -pumps + Na

AARHUS UNIVERSITY PRESS

+ + K K

+ Pasma K poo

11 mmoes

+ K

+ + The Na , K pumps keep us going

+ + The Na , K pumps keepusgoing + + How passîve and actîve transport of sodîum (Na ) and potassîum (K ) contro performance and fatîgue în skeeta musce.

ByTorben Causen, professor emerîtus, MD, Department of Bîomedîcîne, Aarhus Unîversîty

Aarhus University Pressa

+ + The Na , K pumps keep us going © Torben Clausen and Aarhus University Press 2016 Cover: Nethe Ellinge Nielsen, Trefold Layout and typesetting: Narayana Press Publishing Editor: Simon Olling Rebsdorf This book is typeset in Candida & Grotesque E-book production by Narayana Press, Denmark

ISBN 978 87 7184 247 0

Aarhus University Press Langelandsgade 177 DK-8200 Aarhus N Denmark www.unipress.dk

Published with the financial support of Aarhus University Research Foundation

International distributors: Gazelle Book Services Ltd. White Cross Mills Hightown, Lancaster, LA1 4XS United Kingdom www.gazellebookservices.co.uk

ISD 70 Enterprise Drive, Suite 2 Bristol, CT 06010 USA www.isdistribution.com

/ In accordance with requirements of the Danish Ministry of Higher Education and Science, the certification means that a PhD level peer has made a written assessment justifying this book’s scientific quality.

Contents

Section

01 02

03

04 05 06

07 08 09

10 11 12

Preface

+ + The Na , K pump and îts dîscovery

+ + The Transport and dîstrîbutîon of Na and K în skeeta musce and how they are quantîied

+ + Rapîd passîve luxes of Na and K start musce contractîon and set a îmît to excîtabîîty

+ + The deinîtîon, structure and functîon of the Na , K -pump

+ + The synthesîs and ocaîzatîon of the Na , K pumps în skeeta musce

3 Measurements of the content of [ H]ouabaîn bîndîng sîtes îndîcate that + + în skeeta musce, the major part of these bîndîng sîtes of the Na , K pumps are ocaîzed on the outer surface of sarcoemma and în the t-tubues

+ + The content of Na , K pumps în skeeta musces and how ît can be quantîied

+ + Musce contractîons, Na , K transport and sodîum potassîum fatîgue

3 The rate of [ H]ouabaîn bîndîng to sarcoemma can be quantîied and what înformatîon may thîs provîde?

3 Measurements of [ H]ouabaîn bîndîng to other ce types and preparatîons

+ + Acute and ong-term reguatîon of Na , K pumps în skeeta musce

Catechoamînes and caffeîne

Page

7

9

14

17

27

29

30

34

41

43

44

50

57

Section

13 14 15 16 17 18

19 20 21 22

23 24 25 26 27 28

+ + Peptîde hormones stîmuatîng the Na , K pumps

Insuîn-îke growth Factor-I (IGF-I)

CGRP and other cacîtonîns

+ + Amyîn, reated peptîdes, and other stîmuî for the Na , K -pumps

+ The împortance of Na -înlux în causîng depoarîzatîon and musce fatîgue

+ + + Effect of varyîng Na , K -pump stîmuatîng agents on întraceuar Na în rat soeus musces and how thîs may compensate functîona defects caused by pasma membrane eakage

+ + Long-Term Reguatîon of Na , K Pump Content

Traînîng, înactîvîty and denervatîon

Muscuar dystrophy and McArde dîsease

Hyperkaemîc perîodîc paraysîs în horses, human subjects and mutant mîce wîth a sîmîar genetîc anomay

+ + K deicîency and K restoratîon

Thyroîd hormones and starvatîon

Thermogenîc actîons of thyroîd hormones and maîgnant hyperthermîa (MH)

Dîabetes

Steroîd hormones, Gucocortîcoîds, Adosterone

Major Concusîons and Genera Perspectîves

References

Page

60

64

67

69

72

75

77

79

81

88

93

96

99

100

102

104

107

Preface

This book approaches readers with an inter- est in biology and sports and who have per- haps been planning to do research or to study physiology and biochemistry. With figures, diagrams, curves and tables, the book seeks + to explain how a single molecule, the Na , + K pump, creates the conditions required for muscles to work. This happens by the coordination and control of the work of the 12 + + billions (10 ) of Na , K pumps transporting + + Na and K across the membranes of muscle cells. This vital process continues every sec- ond, day and night. It requires energy, but in return allows the muscles to develop their often considerable work in a goal-directed and dirigible manner. This control is exerted by the nervous system acting on the skeletal muscle cells, the contraction of which we are responsible for. In addition, the activity + + and number of Na , K pumps in the muscles are regulated by hormones, by training or inactivity, and are failing in connection to

+ + a number of diseases. Thus, the Na , K - pumps are favouring the working capacity of the muscles, performance, and fitness. Knowledge about their function promotes the understanding of muscle physiology and function, causes of fatigue, endurance, and capacity for maximum performance. In short, + + the Na , K pumps keep us going.  The author was trained as an MD and has 50 years of experience with teaching and re- search in muscle and general physiology as assistant professor and full professor of hu- man physiology at the health faculty of Aar- hus University in Denmark. Professor Jens Christian Skou was supervising his doctoral thesis. He has published 215 articles about physiology, which have been quoted around 10.000 times in the international literature. The information presented in this book is based upon a selection of these publications, their illustrations and those of other authors working in the same area.

Tabe of Contents Thîs page îs protected by copyrîght and may not be redîstrîbuted.

7

Tabe of Contents Thîs page îs protected by copyrîght and may not be redîstrîbuted.