The Newborn Lung: Neonatology Questions and Controversies E-Book
501 pages
English

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Description

The Newborn Lung, a volume in Dr. Polin’s Neonatology: Questions and Controversies Series, offers expert authority on the toughest challenges in neonatal pulmonology and respiratory care. This medical reference book will help you provide better evidence-based care and improve patient outcomes with research on the latest advances.

  • Reconsider how you handle difficult practice issues with coverage that address these topics head on, offering opinions from the leading experts in the field, supported by the best available evidence.
  • Find information quickly and easily with a consistent chapter organization.
  • Get the most authoritative advice available from world-class neonatologists who have the inside track on new trends and developments in neonatal care.
  • Stay current in practice with in-depth coverage of presentation, pathogenesis, epidemiology, and prevention of bronchopulmonary dysplasia; short and long-term outcomes of oxygenation strategies in preterm infants; and many other hot topics in neonatal respiratory care.

Sujets

Ebooks
Savoirs
Medecine
Médecine
Desprendimiento prematuro de placenta
Célula madre
Chronic obstructive pulmonary disease
Laser photocoagulation
Photocopier
Thiosulfate sulfurtransferase
Emphysema
Pro-oxidant
Respiratory minute volume
Hypoxia
Chorioamnionitis
Respiratory tract infection
Bronchopulmonary dysplasia
Respiratory physiology
Transforming growth factor beta
Hypoxemia
Piperacillin
Hyperoxia
Prenatal development
Necrotizing enterocolitis
Pulmonary surfactant
Congenital diaphragmatic hernia
Sequela
Neonatology
Respiratory acidosis
Indometacin
Atelectasis
Muscle contraction
Retinal detachment
Choanal atresia
Probiotic
Ventricular tachycardia
Pulmonary hypertension
Pulmonary circulation
Pulmonology
Patent ductus arteriosus
Oxygen therapy
Acute respiratory distress syndrome
Physician assistant
Human respiratory syncytial virus
Endotoxin
Retinopathy of prematurity
Positive airway pressure
Temperance (virtue)
Preterm birth
Pulmonary edema
Cor pulmonale
Heart rate
Lung volumes
Tidal volume
Hemodynamics
Medical ventilator
Nitric oxide
Borderline personality disorder
Surfactant
Superoxide
Nutrient
Cardiopulmonary resuscitation
Hematology
Cardiac arrest
Circulatory system
Obstetrics and gynaecology
Pneumonia
Cystic fibrosis
Philadelphia
Respiratory therapy
Electrolyte
Asthma
Address
Infection
Lung
Data storage device
Pediatrics
Oxygen
Nephrology
Morphogenesis
Mechanics
Immunology
Infectious disease
Gastroenterology
Function
Cardiology
ECMO
Ureaplasma
Proven
Pneumothorax
Gene
Vascular endothelial growth factor
Consultant
Electronic
Automation
Service
Expiration
Furosémide
Menstruation
Death
Respiration
Nutrition
Copyright
Colon

Informations

Publié par
Date de parution 11 mars 2012
Nombre de lectures 1
EAN13 9781455738229
Langue English
Poids de l'ouvrage 7 Mo

Informations légales : prix de location à la page 0,0253€. Cette information est donnée uniquement à titre indicatif conformément à la législation en vigueur.

Extrait

The Newborn Lung
Neonatology Questions and Controversies
SECOND EDITION
Eduardo Bancalari, MD
Professor of Pediatrics, Obstetrics and Gynecology, Director, Division of Neonatology,
Department of Pediatrics, University of Miami, Miller School of Medicine, Chief Newborn
Service, Jackson Memorial Hospital, Miami, FloridaTable of Contents
Cover image
Title page
Series Page
Copyright
Contributors
Series Foreword
Preface
Section A: Normal and Abnormal Lung Development
Chapter 1: Molecular Bases for Lung Development, Injury, and Repair
Stages of Lung Development
Molecular Regulation of Lung Bud Initiation and Tracheal-Esophageal Separation
Epithelial-Mesenchymal Interactions Control Branching Morphogenesis
Regulatory Mechanisms of Alveologenesis
Regulation of Pulmonary Vascular Development
Lung Injury and Repair: Disruption of Normal Lung Development
Conclusions
Chapter 2: Genetic Influences in Lung Development and Injury
Genetic Influences in Lung Development: Animal Models
Genetic Influences in Lung Development: Clinical Context of RDS
Genetic Influences in Injury to the Developing LungGenetic Influences in Injury to the Developing Lung: Clinical Context of BPD
Conclusions
Acknowledgments
Chapter 3: Perinatal Events and Their Influence on Lung Development and Function
Overview of Lung Development and Perinatal Events
Lung Development: The Substrate for Adverse Events
Lung Maturation
Antenatal Corticosteroids
Antenatal Infection/Inflammation
Summary: The Complexities
Chapter 4: Hypoxia and Hyperoxia: Effects on the Newborn Pulmonary Circulation
Overview of Reactive Oxygen Species
Hypoxia and the Pulmonary Circulation
Hyperoxia and the Pulmonary Circulation
Therapeutic Implications
Acknowledgments
Chapter 5: The Role of Nitric Oxide in Lung Growth and Function
Fetal Lung Development
Angiogenic Factors and Their Receptors
Nitric Oxide and Lung Development
Role of Nitric Oxide in Lung Repair
Regulation of NOS Activity through L-Arginine Availability
Interaction of Antioxidant Enzyme Systems with Endogenous Nitric Oxide
Relationship of Oxygen Tension with NOS Function and Lung Growth during Fetal
Life
Physiologic Role of Nitric Oxide in the Gas Exchange Function of the Lung
Altered Lung Architecture in BPD and Its Relation to NOS Signaling
Application of Inhaled Nitric Oxide to Restore Lung Growth in Premature NeonatesSummary
Acknowledgments
Section B: Lung Injury—Bronchopulmonary Dysplasia
Chapter 6: Prenatal and Postnatal Microbial Colonization and Respiratory Outcome in
Preterm Infants
Introduction
Antenatal Infection and Pulmonary Outcomes
Postnatal Microbial Colonization and Adverse Pulmonary Outcomes
Acknowledgments
Chapter 7: Influence of Nutrition on Neonatal Respiratory Outcomes
Preterm Infant Nutrition
Undernutrition, Growth Failure, and Pulmonary Consequences
Adequate Nutrition to Support Lung Growth and Function
Conclusion
Chapter 8: Patent Ductus Arteriosus and the Lung: Acute Effects and Long-Term
Consequences
Why Does the Ductus Arteriosus Remain Open in Preterm Infants?
Surfactant Treatment and PDA
Systemic Consequences of PDA
Pulmonary Consequences of PDA
PDA and Bronchopulmonary Dysplasia
Management of PDA and Respiratory Outcome
Respiratory Management of Infants with PDA
Summary
Chapter 9: Role of Stem Cells in Neonatal Lung Injury
Stem Cells
Exogenous Stem Cells for Lung Repair
Bone Marrow–Derived Stem Cells and Lung DiseaseMechanisms of Stem Cell Repair
Lung Bioengineering
Endogenous Lung Stem Cells
Endogenous Circulating Stem Cells
Conclusion
Acknowledgments
Chapter 10: New Developments in the Pathogenesis and Prevention of
Bronchopulmonary Dysplasia
New Developments in Clinical Presentation
New Developments in Understanding of BPD Pathogenesis
New Developments in Prevention and Management of BPD
Future Directions in Prevention of BPD
Conclusion
Chapter 11: Long-Term Pulmonary Outcome of Preterm Infants
Controversies
What Are the Long-Term Pulmonary Outcomes for Late Preterm Infants?
What are the Long-Term Pulmonary Outcomes for Very Preterm Infants, and
What Is the Effect of Having BPD on These Outcomes?
What Further Research is Required?
Summary
Section C: Management of Respiratory Failure
Chapter 12: Respiratory and Cardiovascular Support in the Delivery Room
Anticipate the Need for Resuscitation
Prepare
Initial Assessment: “The Golden Minute”
Initial Steps of Resuscitation
Effective Ventilation: The Key!
CPAPIntubation or Laryngeal Mask Airway
Oxygenation
Cardiac Compressions during Delivery Room Resuscitation
Medications during Delivery Room Resuscitation
Special Situations
Chapter 13: Noninvasive Respiratory Support: An Alternative to Mechanical Ventilation
in Preterm Infants
Physiological Principles
A Brief History of Invasive and Noninvasive Neonatal Ventilation
NCPAP for Postextubation Care
Augmenting NCPAP: Nasal Intermittent Positive-Pressure Ventilation
NCPAP for Babies with RDS or at Risk of Developing RDS
NCPAP Devices
How Much Supporting Pressure Should Be Used?
Complications of NCPAP
When Has NCPAP Failed (i.e., When Should Infants be Intubated)?
Weaning CPAP
High-Flow Nasal Cannulae for Respiratory Support
Conclusions
Acknowledgments
Chapter 14: Surfactant Replacement: Present and Future
Introduction
Recommendations for Surfactant Use in 2010
Which Surfactant Is Best?
What Dose Should Be Used?
When Should Surfactant Be Given?
Should We Use More than One Dose of Surfactant in RDS?
Surfactant Administration and Ventilation
Surfactant without IntubationSurfactant for Other Neonatal Respiratory Disorders
The Future
Chapter 15: Oxygenation Targeting and Outcomes in Preterm Infants: The New
Evidence
Historical Perspectives
Physiologic Considerations
The Critical Threshold of Fetal Oxygenation
Oxygenation during Fetal-to-Neonatal Transition
Oxygen Toxicity in Preterm Infants
“Normal” Levels of Oxygenation in Newborns
Optimal Levels of Oxygenation in Preterm Infants: Neonatal Period
Optimal Levels of Oxygenation in Preterm Infants: Post-neonatal Period
Approaches to Oxygen Therapy and Clinical Outcomes
Controversies in Oxygen Therapy
Resolving the Uncertainty: The Oxygen Saturation Trials
New Evidence on Oxygenation Targets in Preterm Infants
Chapter 16: Hypoxemic Episodes in the Premature Infant: Causes, Consequences,
and Management
Mechanisms
Management of Hypoxemia Spells in Ventilated Infants
Episodes of Hypoxemia after Extubation
Consequences of Hypoxemia Episodes in the Premature Infant
Summary
Chapter 17: Patient-Ventilator Interaction
Conventional Mechanical Ventilation
Synchronized Mechanical Ventilation
Infant-Ventilator Interaction during Noninvasive Ventilation
SummaryChapter 18: Strategies for Limiting the Duration of Mechanical Ventilation
Weaning Ventilator Settings
Modes of Ventilation and Weaning
Prediction of Successful Extubation
Automatic Weaning
Conclusion
Chapter 19: Automation of Respiratory Support
Automation of Mechanical Ventilatory Support
Volume Targeted Ventilation
Targeted Minute Ventilation
Proportional Assist Ventilation
Neurally Adjusted Ventilatory Assist
Automated Adjustment of Supplemental Oxygen
Summary
Chapter 20: Management of the Infant with Congenital Diaphragmatic Hernia
The Pathophysiology of Congenital Diaphragmatic Hernia
Acute Respiratory Management in the Patient with CDH
Assessment and Management of Pulmonary Hypertension
Approach to Patients with Congenital Heart Disease
Longer-Term Issues in Survivors of CDH
Antenatal Therapies
Chapter 21: Management of the Infant with Severe Bronchopulmonary Dysplasia
Pathophysiology of Severe BPD
Evaluation and Treatment
Long-Term Outcomes
IndexSeries Page
THE NEWBORN LUNG
Neonatology Questions and Controversies
Series Editor
Richard A. Polin, MD, Professor of Pediatrics
College of Physicians and Surgeons
Columbia University
Vice Chairman for Clinical and Academic Affairs
Department of Pediatrics
Director, Division of Neonatology
Morgan Stanley Children's Hospital of NewYork-Presbyterian
Columbia University Medical Center
New York, New York
Other Volumes in the Neonatology Questions and Controversies Series
GASTROENTEROLOGY AND NUTRITION
HEMATOLOGY, IMMUNOLOGY AND INFECTIOUS DISEASE
HEMODYNAMICS AND CARDIOLOGY
NEPHROLOGY AND FLUID/ELECTROLYTE PHYSIOLOGY
NEUROLOGYC o p y r i g h t
1600 John F. Kennedy Blvd.
Ste 1800
Philadelphia, PA 19103-2899
The Newborn Lung Neonatology Questions and Controversies, Second Edition ISBN:
978-1-4377-2682-4
Copyright © 2012, 2008 by Saunders, an imprint of Elsevier, Inc.
All rights reserved. No part of this publication may be reproduced or transmitted in
any form or by any means, electronic or mechanical, including photocopying,
recording, or any information storage and retrieval system, without permission in
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