Uric Acid in Chronic Kidney Disease

Description

Hyperuricemia is often associated with life-style related disorders such as diabetes mellitus, hypertension, and dyslipidemia, which, in turn, are major causes of CKD. Improved management of hyperuricemia is thus expected to be beneficial for both the general population and CKD patients. This book presents new information on uric acid in tubular transport, early recognition of renal lesions, genetic predisposition, preeclampsia, metabolic syndrome, diabetes, high blood pressure in the young, and the relationship with vitamin D. Moreover, the relationship between AKI and uric acid, as well as the rejection of renal transplants due to hyperuricemia, are discussed. This publication will be of interest to both general practitioners and researchers working in the field of CKD. It provides new insights into renal damage caused by hyperuricemia and into prevention and treatment possibilities.

Informations

• Publié par: S. Karger AG
• Date de parution: 23 janvier 2018
• Nombre de lectures: 0
• EAN13: 9783318062519
• Langue: English
• Poids de l'ouvrage: 2 Mo

Extrait

Uric Acid in Chronic Kidney Disease
Contributions to Nephrology
Vol. 192
Series Editor
Claudio Ronco Vicenza
 
Uric Acid in Chronic Kidney Disease
Volume Editors
Alejandro Treviño-Becerra Mexico City
Kunitoshi Iseki Okinawa
18 figures, 3 in color, and 11 tables, 2018
Contributions to Nephrology
(Founded 1975 by Geoff rey M. Berlyne)
_______________________ Alejandro Treviño-Becerra Uremic and Dialysis Clinic Tuxpan 16–104 Col. Roma 06760 México City (México)
_______________________ Kunitoshi Iseki Clinical Research Support Center Tomishiro Central Hospital 25 Ueta, Tomigusuku Okinawa 901–0243 (Japan)
Library of Congress Cataloging-in-Publication Data
Title: Uric acid in chronic kidney disease / volume editors, Alejandro Treviño-Becerra, Kunitoshi Iseki.
Other titles: Contributions to nephrology ; v. 192. 0302-5144
Description: Basel ; New York : Karger, [2018] | Series: Contributions to nephrology, ISSN 0302-5144 ; vol. 192 | Includes bibliographical references and indexes.
Identifiers: LCCN 2017057195| ISBN 9783318062502 (hard cover : alk. paper) | ISBN 9783318062519 (e-ISBN)
Subjects: | MESH: Renal Insufficiency, Chronic | Hyperuricemia | Uric Acid--blood | Diabetic Nephropathies | Gout
Classification: LCC RC632.H89 | NLM WJ 342 | DDC 616.3/99--dc23 LC record available at
https://lccn.loc.gov/2017057195
 
Bibliographic Indices. This publication is listed in bibliographic services, including Current Contents® and IndexMedicus.
Disclaimer. The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publisher and the editor(s). The appearance of advertisements in the book is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
Drug Dosage. The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any change in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
© Copyright 2018 by S. Karger AG, P.O. Box, CH–4009 Basel (Switzerland)
www.karger.com
Printed on acid-free and non-aging paper (ISO 9706)
ISSN 0302–5144
e-ISSN 1662–2782
ISBN 978–3–318–06250–2
e-ISBN 978–3–318–06251–9
 
Contents
Foreword
Treviño-Becerra, A. (Mexico City)
Introduction
Treviño-Becerra, A. (Mexico City); Iseki, K. (Okinawa)
Renal Handling of Uric Acid
Andrade Sierra, J.; Flores Fonseca, M.M. (Guadalajara)
Renal Effects of Hyperuricemia
Méndez Landa, C.E. (Mexico City)
The Pathophysiology of Uric Acid on Renal Diseases
Sánchez-Lozada, L.G. (Mexico City)
Uric Acid: The Unknown Uremic Toxin
Treviño-Becerra, A. (Mexico City)
The Association between Serum Uric Acid and Renal Damage: The Takahata Study – New Insights
Konta, T.; Kamei, K.; Ichikawa, K.; Kayama, T.; Kubota, I. (Yamagata)
Significance of Hyperuricemia among Community-Based Screening Participants
Iseki, K. (Okinawa)
Hyperuricemia and Progression of Chronic Kidney Disease: Role of Phenotype Transition of Renal Tubular and Endothelial Cells
Kang, D.-H. (Seoul)
Time to Target Uric Acid to Retard Chronic Kidney Disease Progression
Uchida, S.; Kumagai, T. (Tokyo); Chang, W.X. (Tianjin); Tamura, Y.;
Shibata, S. (Tokyo)
Uric Acid: The Lower the Better?
Bellomo, G.; Selvi, A. (Perugia)
Gout: A Disease of Kings
Tang, S.C.W. (Hong Kong)
Systemic Implications of Hyperuricemia
Tamayo y Orozco, J.A. (Mexico City)
Uric Acid as a Cause of the Metabolic Syndrome
King, C.; Lanaspa, M.A.; Jensen, T. (Aurora, CO); Tolan, D.R. (Boston, MA);
Sánchez-Lozada, L.G. (Mexico City); Johnson, R.J. (Aurora, CO)
Uric Acid and Diabetic Nephropathy Risk
Mauer, M. (Minneapolis, MN); Doria, A. (Boston, MA)
Uric Acid in Pregnancy: New Concepts
Moreno Santillan, A.A.; Briones Garduño, J.C.;
Diaz de Leon Ponce, M.A. (Mexico City)
Uric Acid Renal Lithiasis: New Concepts
Pazos Pérez, F. (Mexico City)
Clinical Significance of Serum Uric Acid Levels in Mexican Young Adults
Alegría-Díaz, A.; Valdez-Ortiz, R. (Mexico City); Murguía-Romero, M.;
Jiménez-Flores, R.; Villalobos-Molina, R. (Tlalnepantla); Mummidi, S.;
Duggirala, R. (Edinburg, TX); López-Alvarenga, J.C. (Edinburg, TX/ Reynosa Tamaulipas); Pérez-Navarro, M. (Mexico City)
Treatment of Hyperuricemia in Chronic Kidney Disease
Ramirez-Sandoval, J.C.; Madero, M. (Mexico City)
Author Index
Subject Index
 
Foreword
 
I am very grateful to the Editorial Division of Karger Publishers for choosing to publish this book in the prestigious Contributions to Nephrology series. This publication aims to achieve the widespread dissemination of recent knowledge acquired in the field of nephrology, especially in light of the cancellation of the International Satellite Symposium on Uric Acid in Chronic Renal Disease that was to be held in April 2017.
In 1979, I had the opportunity to publish the 17th volume of this series, entitled Today’s Art of Peritoneal Dialysis, following the First International Symposium on Peritoneal Dialysis held in Chapala, Jalisco, Mexico in 1978. Dr. Fred S.T. Boen, who sadly passed away in 2017, was the coeditor. That publication contributed much to the global objective of improving processes related to the development of peritoneal dialysis. I sincerely hope that this latest edition will also aid the enhancement of current knowledge on this subject.
In 1979 I was just beginning my career in the field of nephrology. Now, almost 40 years later, I consider my involvement in publishing volume 192 of the series as a significant milestone in my career. I would like to express my gratitude to all the authors, especially Prof. Kunitoshi Iseki, who worked diligently to procure several chapters of this volume from other outstanding colleagues in Asia and a friendly recognition of Prof. Claudio Ronco for his interest in this field of the medicine and his enthusiastic support of this publication.
Dr. Alejandro Treviño-Becerra
 
Introduction
 

The idea of conducting a scientific meeting devoted to uric acid and chronic renal diseases was developed during the 8th and 9th Congresses of Uremia Toxicity and Research held in Okinawa, Japan, and Guadalajara, Mexico. In April 2016, during the 17th international Congress of Nutrition and Metabolism of Renal Diseases in Okinawa, a committee was formed with Prof. Kunitoshi Iseki and myself as the chairmen. Faculty members were invited to plan an interesting program, the products of which are published in this book.
Unfortunately, for various reasons, the symposium had to be cancelled just a few weeks before its scheduled event. However, the authors decided to remain true to their commitment to make possible the publication of their work, for which I am grateful to them all.
More than 30 years ago, in order to become a member of the National Academy of Medicine in Mexico, I presented my work relating to studies performed on 23 patients with uric acid reduction. This was achieved through an isocaloric, low-protein, and purine diet, as well as high doses of allopurinol, resulting in a blood urea reduction of 15–20% and a slightly increased creatinine clearance of up to 15–20%. Since then, we have routinely used the findings of those studies to acquire the benefits of low blood uric acid in our patients, which from the initiation of treatment provides relief through the reduction of some of their symptoms, mainly related to the gastrointestinal system. This in turn allows them to feel better and more able to cope with their diets.
This book includes chapters relating to new uric acid concepts in tubular transport and the early recognition of renal lesions due to an environmental and genetic predisposition to high blood uric acid. Also covered are the effects of high blood uric acid in preeclampsia, metabolic syndrome, diabetes, high blood pressure in the young, and the relationship between uric acid and vitamin D.
Interesting discussion is included of uric acid as a factor in the acceleration of renal diseases, and the effects of hyperuricemia on the progression of chronic renal failure. The benefits of low uric acid in the prognosis of chronic uremia are also considered. Finally, interesting observations from a study group that achieved low blood uric acid values