Free Radical Biology in Digestive Diseases

Description

There is a growing body of experimental and clinical data to suggest that the organs of the digestive system may be subjected to considerable oxidative stress associated with acute and chronic inflammation. Although inflammation and ischemia play a key role in producing oxygen-derived free radicals in the digestive tract, the contribution of other factors, such as transition metal imbalances, lipid and glucose metabolic disturbance, and the interaction with gaseous molecules including nitric oxide and carbon monoxide, has also been suggested. Recent studies have demonstrated that several biomarkers indicating oxidative stress-mediated damage may help in monitoring the degree of disease and planning the design of new therapeutic strategies. In addition, recent advances in ‘omics’ research (genomics, proteomics, metabolomics, etc.) may bring a breakthrough in the field of gastroenterology and hepatology: Several molecular targets for oxidative stress have been presented by the ‘omics’.This book includes up-to-date reviews on the relevant issues in free radical biology in a combination with expert basic research reviews and clinical aspects in gastroenterology and hepatology.Providing information about new molecular targets for the treatment or prevention of digestive diseases, this book should be read by clinical and basic researchers in gastroenterology and hepatology.

Informations

• Publié par: S. Karger AG
• Date de parution: 21 décembre 2010
• Nombre de lectures: 0
• EAN13: 9783805596107
• Langue: English
• Poids de l'ouvrage: 2 Mo

Extrait

Free Radical Biology in Digestive Diseases
Frontiers of Gastrointestinal Research
Vol. 29
Series Editor
Markus M. Lerch     Greifswald
 
Free Radical Biology in Digestive Diseases
Volume Editors
Yuji Naito     Kyoto, Japan
Makoto Suematsu     Tokyo, Japan
Toshikazu Yoshikawa     Kyoto, Japan
36 figures, 3 in color, and 9 tables, 2011
Frontiers of Gastrointestinal Research
Founded 1975 by L. van der Reis, San Francisco, Calif.
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Dr. Yuji Naito Molecular Gastroenterology and Hepatology Kyoto Prefectural University of Medicine 465 Kajii-cho, Kamigyo-ku Kyoto 602-8566 Japan
Makoto Suematsu Department of Biochemistry School of Medicine Keio University 35 Shinanomachi, Shinjuku-ku Tokyo 160-8582 Japan
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Toshikazu Yoshikawa Molecular Gastroenterology and Hepatology Kyoto Prefectural University of Medicine 465 Kajii-cho, Kamigyo-ku Kyoto 602-8566 Japan
 
Library of Congress Cataloging-in-Publication Data
Free radical biology in digestive diseases / volume editors, Yuji Naito, Makoto Suematsu, Toshikazu Yoshikawa.
p. ; cm. –– (Frontiers of gastrointestinal research, ISSN 0302-0665 ; v. 29)
Includes bibliographical references and indexes.
ISBN 978-3-8055-9609-1 (hard cover: alk. paper) –– ISBN 978-3-8055-9610-7 (e-ISBN)
1. Digestive organs––Pathophysiology. 2. Free radicals (Chemistry)––Pathophysiology. 3. Active oxygen––Pathophysiology. I. Naito, Yuji. II. Suematsu, M. (Makoto), 1957-III. Yoshikawa, Toshikazu, 1947-IV. Series: Frontiers of gastrointestinal research ; v. 29. 0302-0665
[DNLM: 1. Gastrointestinal Diseases––physiopathology. 2. Oxidative Stress––physiology. 3. Oxidoreductases––therapeutic use. 4. Reactive Oxygen Species––adverse effects. W1 FR946E v.29 2011 / WI 140]
RC802.9.F74 2011
616.3––dc22
2010038816
Bibliographic Indices. This publication is listed in bibliographic services, including Current Contents®
Disclaimer. The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publisher and the editor(s). The appearance of advertisements in the book is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
Drug Dosage. The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any change in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
© Copyright 2011 by S. Karger AG, P.O. Box, CH-4009 Basel (Switzerland)
www.karger.com
Printed in Switzerland on acid-free and non-aging paper (ISO 9706) by Reinhardt Druck, Basel
ISSN 0302–0665
ISBN 978–3–8055–9609–1
e-ISBN 978–3–8055–9610–7
 
Contents
Preface
Naito, Y. (Kyoto); Suematsu, M. (Tokyo); Yoshikawa, T. (Kyoto)
Free Radical Biology
Free Radicals and Lipid Peroxidation
Niki, E. (Kyoto/Ikeda)
Mitochondria as Source of Free Radicals
Majima, H.J.; Indo, H.P.; Suenaga, S. (Kagoshima); Kaneko, T.; Matsui, H. (Tsukuba); Yen, H.C. (Tao-Yuan); Ozawa, T. (Kanagawa)
The Nox Family of NADPH Oxidases that Deliberately Produce Reactive Oxygen Species
Sumimoto, H.; Minakami, R.; Miyano, K. (Fukuoka)
Neutrophil-Dependent Oxidative Stress in Inflammatory Gastrointestinal Diseases
Naito, Y.; Yoshikawa, T. (Kyoto)
Oxidative DNA Damage and Carcinogenesis
Jiang, L.; Toyokuni, S. (Nagoya)
Plasma Marker of Oxidative Stress in Circulation and in Tissue
Yamamoto, Y. (Tokyo)
Immunochemical Detection of 4-Hydroxy-2-Nonenal-Specific Epitopes
Uchida, K. (Nagoya)
Carbon Monoxide-Dependent Regulation of Microvascular Function: One Gas Regulates Another
Suematsu, M.; Kajimura, M.; Kabe, Y. (Tokyo)
Nrf2-Keap1 Signaling as a Common Chemopreventive Target of Antioxidative and Anti-Inflammatory Phytochemicals
Surh, Y.-J. (Seoul)
Free Radicals in Digestive Diseases
Free Radicals and Gastric Mucosal Injury
Ock, C.Y.; Hong, K.S.; Kim, J.H.; Hahm, K.-B. (Incheon)
Free Radicals in Helicobacter pylori Infection
Suzuki, H.; Nishizawa, T.; Tsugawa, H.; Hibi, T. (Tokyo)
Free Radical and Nonsteroidal Anti-Inflammatory Drug-Induced Small Intestinal Injury
Handa, O.; Naito, Y. (Kyoto)
Free Radicals in Inflammatory Bowel Disease
Takagi, T.; Naito, Y.; Yoshikawa, T. (Kyoto)
Free Radicals and Chronic Hepatitis C
Sakaida, I. (Ube)
Free Radicals and Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis
Sumida, Y. (Nara); Naito, Y.; Yoshikawa, T. (Kyoto)
Role of Free Radicals in Pancreatitis
Hamada, S.; Shimosegawa, T. (Sendai)
Free Radicals and Cancer Treatment
Kokura, S. (Kyoto)
Author Index
Subject Index
 
Preface
In 1981, Granger et al. [ 1 ] demonstrated for the first time that superoxide radicals, oxygen-derived free radicals, are mainly responsible for the increased capillary permeability in the ischemic bowel. In 1985, Itoh and Guth [ 2 ] found that SOD, a superoxide dismutase, could significantly protect against gastric mucosal injury induced by a withdrawal for 20 min and reperfusion in rats. In 1989, Yoshikawa et al. [ 3 ] have produced a new animal model of reperfusion-induced gastric mucosal injury in rats by applying a vascular clamp to the celiac artery, then removing it. Using this model, they have demonstrated that oxygen-derived free radicals and their scavenging system play a crucial role in the pathogenesis of gastric mucosal injury induced by ischemia-reperfusion. Subsequently, various studies have described the role of free radicals in the development of animal models of digestive diseases. There is a growing body of experimental and clinical data to suggest that the organs of the digestive system may be subjected to considerable oxidative stress associated with acute and chronic inflammation. Although inflammation and ischemia play a key role in producing oxygen-derived free radicals in the digestive organ, the contribution of other factors, such as transition metal imbalance, lipid and glucose metabolic disturbance, and the interaction with gaseous molecules including nitric oxide and carbon monoxide, has also been suggested. Recent studies have demonstrated that several biomarkers indicating oxidative stress-mediated damage, such as 4-hydroxy-2-nonenal, nitrotyrosine, 8-hydroxydeoxyguanosine, and more specific lipid peroxides for free radical reaction, may help in monitoring the degree of disease and planning the design of new therapeutic strategies. In addition, recent advances in ‘omics’ research (genomics, proteomics, metabolomics, etc.) may bring a breakthrough in the field of gastroenterology and hepatology. Several molecular targets for oxidative stress have been presented by the ‘omics’. In this book, we invited several outstanding researchers in the field of free radical biology as well as gastroenterology and hepatology to summarize their work, to review their peers’ activity, and to encourage us by their opinions. We thank all the anonymous reviewers for their insightful comments. Finally, we thank Karger Publishers for their cooperation in bringing out this book.
Yuji Naito , Kyoto Makoto Suematsu , Tokyo Toshikazu Yoshikawa , Kyoto
References
1 Granger DN, Rutili G, McCord JM: Superoxide radicals in feline intestinal ischemia. Gastroenterology 1981;81:22–29.
2 Itoh M, Guth PH: Role of oxygen-derived free radicals in hemorrhagic shock-induced gastric lesion in rats. Gastroenterology 1985;88:1162-1167.
3 Yoshikawa T, Ueda S, Naito Y, Takahashi S, Oyamada H, Morita Y, Yoneta T, Kondo M: Role of oxygen-derived free radicals in gastric mucosal injury induced by ischemia or ischemia-reperfusion in rats. Free Radic Res Commun 1989;7:285–291.
Free Radical Biology
Naito Y, Suematsu M, Yoshikawa T (eds): Free Radical Biology in Digestive Diseases. Front Gastrointest Res. Basel, Karger, 2011, vol 29, pp 1-11
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Free Radicals and Lipid Peroxidation
Etsuo Niki
Kyoto Prefectural University of Medicine, Kyoto, National Institute of Advanced Industrial Science and Technology, Ikeda, Japan
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Abstract
Lipid peroxidation has been implicated in the pathogenesis of various disorders and diseases. Free and ester for