Physicists regularly invoke universal laws, such as those of motion and electromagnetism, to explain events. Biological and medical scientists have no such laws. How then do they acquire a reliable body of knowledge about biological organisms and human disease? One way is by repeatedly returning to, manipulating, observing, interpreting, and reinterpreting certain subjects-such as flies, mice, worms, or microbes-or, as they are known in biology, "model systems." Across the natural and social sciences, other disciplinary fields have developed canonical examples that have played a role comparable to that of biology's model systems, serving not only as points of reference and illustrations of general principles or values but also as sites of continued investigation and reinterpretation. The essays in this collection assess the scope and function of model objects in domains as diverse as biology, geology, and history, attending to differences between fields as well as to epistemological commonalities.Contributors examine the role of the fruit fly Drosophila and nematode worms in biology, troops of baboons in primatology, box and digital simulations of the movement of the earth's crust in geology, and meteorological models in climatology. They analyze the intensive study of the prisoner's dilemma in game theory, ritual in anthropology, the individual case in psychoanalytic research, and Athenian democracy in political theory. The contributors illuminate the processes through which particular organisms, cases, materials, or narratives become foundational to their fields, and they examine how these foundational exemplars-from the fruit fly to Freud's Dora-shape the knowledge produced within their disciplines.ContributorsRachel A. AnkenyAngela N. H. CreagerAmy Dahan DalmedicoJohn ForresterClifford GeertzCarlo GinzburgE. Jane Albert HubbardElizabeth LunbeckMary S. MorganJosiah OberNaomi OreskesSusan SperlingMarcel WeberM. Norton Wise
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Inroducion Ā n g e l Ā n . H . C r e Āg e r , e l i z Ā b e t H l u n b e C k , Ā n d M . n o rto n W i s e
pa rt 1 : B i o L o g y
Redesigning e Frui Fly: he Molecularizaion ofDrosopila
M Ā rC e l W e b e r
Wormy Logic: Model Organisms as Case-Based Reasoning r ĀC H e l Ā . Ā n k e n y
Model Organisms as Powerful Tools for Biomedical Researc e . J Ā n e Ā l b e rt H u b b Ā r d
he Troop Trope: Baboon Beavior as a Model Sysem in e Poswar Period s u s Ā n s p e r l i n g
pa rt 2 : S i M u L at i o n S
From Scaling o Simulaion: Canging Meanings and Ambiions of Models in Geology n Āo M i o r e s k e s
Models and Simulaions in Climae Cange: Hisorical, Episemological, Anropological, and Poliical Aspecs
Ā M y dĀ H Ā n dĀ l M e d i C o
he Curious Case of e Prisoner’s Dilemma: Model Siuaion? Exemplary Narraive? M Ā ry s . M o rg Ā n
c o n t e n t S
pa rt 3 : h u M a n S c i e n c e S
he Psycoanalyic Case: Voyeurism, Eics, and Episemology in Rober Soller’sSexual Exciemen J o H n F o r r e s t e r
“To Exis Is o Have Confidence in One’s Way of Being”: Riuals as Model Sysems
C l i F F o r d g e e rt z
Democraic Aens as an Experimenal Sysem: Hisory and e Projec of Poliical heory J o s i Ā H o b e r
Laiude, Slaves, and e Bible: An Experimen in Microisory C Ā r lo g i n z b u rg
Aterword: Reflecions on Exemplary Narraives, Cases, and Model Organisms M Ā ry s . M o rg Ā n
Conribuors Index
Inroducion
angeLa n. h. creager, eLizaBeth LunBeck, and M. norton wiSe
A e dawn of e weny-firs cenury, e face of biology may well be a of a laboraory mouse. Science wriers, governmen agencies, and researcers alie ou e crucial role played by biology’s experimenal sub-jecs, “model sysems” as ey are ermed, in advancing nowledge. hese crea-ures are no sowcased for eir appeal—e flies, mice, worms, and microbes a are e mainsay of laboraory science would be regarded as vermin or germs ouside eir scienific omes—bu because ey ave become e locus of producing nowledge abou life and disease. To mae e case a improv-ing uman eal ress on our inimae undersanding of a selec se of rodens, fis, ampibians, microbes, and even a plan, e Naional Insiues of Heal () feaures a Web sie iled “Model Organisms for Biomedical Researc” (www.ni.gov/science/models). hese are e organisms wose genomes were sequenced as par of e Human Genome Projec. And as e wans o mae clear, ey are e creaures a sand in for us umans as laboraory bi-ologiss invesigae ow living processes wor—and ow ey go awry. A spe-cial supplemen ohe Scienisiled “Model Organisms” offers feaure aricles on eig suc exemplary forms of life, from e inesinal baceriumEscericia colio e nemaode wormCaenoradbiis elegans(see figure ). As e ediors explain e imporance of is “moley collecion of creaures”:
Researcers seleced is weird and wonderful assormen from ens of millions of possibiliies because ey ave common aribues as well as unique caracerisics. hey’re pracical: A model mus be ceap and plen-iful; be inexpensive o ouse; be sraigforward o propagae; ave sor gesaion periods a produce large numbers of offspring; be easy o ma-nipulae in e lab; and boas a fairly small and (relaively) uncomplicaed genome. his ype of racabiliy is a feaure of all well-used models.1
A one level, e reliance of biomedical researcers on sandardized crea-ures for experimenaion is mere pracical necessiy. Biological maerials are, by eir naure, variable and complex; life scieniss ave soug o conrol e variabiliy ey face by selecing ou and sandardizing paricular experimen-al subjecs. Ye ese organisms, no maer ow sandardized ey become as