Cardiovascular Therapeutics E-Book
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1550 pages
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Description

Manage cardiovascular problems more effectively with the most comprehensive resource available! A trusted companion to Braunwald's Heart Disease, Cardiovascular Therapeutics, 4th Edition addresses pharmacological, interventional, and surgical management approaches for each type of cardiovascular disease. This practical and clinically focused cardiology reference offers a balanced, complete approach to all of the usual and unusual areas of cardiovascular disease and specific therapies in one concise volume, equipping you to make the best choices for every patient.

  • Consult this title on your favorite e-reader with intuitive search tools and adjustable font sizes. Elsevier eBooks provide instant portable access to your entire library, no matter what device you're using or where you're located.
  • Understand current approaches to treating and managing cardiovascular patients for long-term health, for complex problems, and for unusual cardiac events.
  • Benefit from the substantial experience of Elliott M. Antman, MD, Marc S. Sabatine, MD, and a host of other respected authorities, who provide practical, evidence-based rationales for all of today's clinical therapies.
  • Expand your knowledge beyond pharmacologic interventions with complete coverage of the most effective interventional and device therapies being used today.
  • Easily reference Braunwald's Heart Disease, 9th Edition for further information on topics of interest.
  • Make the best use of the latest genetic and molecular therapies as well as advanced therapies for heart failure.
  • Cut right to the answers you need with an enhanced focus on clinically relevant information and a decreased emphasis on pathophysiology.
  • Stay current with ACC/AHA/ESC guidelines and the best ways to implement them in clinical practice.
  • Get an enhanced visual perspective with an all-new, full-color design throughout.

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Informations

Publié par
Date de parution 17 septembre 2012
Nombre de lectures 0
EAN13 9781455737376
Langue English
Poids de l'ouvrage 5 Mo

Informations légales : prix de location à la page 0,0509€. Cette information est donnée uniquement à titre indicatif conformément à la législation en vigueur.

Extrait

Cardiovascular Therapeutics
A Companion to Braunwald’s Heart Disease
Fourth Edition

Elliott M. Antman, MD
Professor of Medicine, Associate Dean for Clinical/Translational Research, Harvard Medical School, Senior Investigator, TIMI Study Group, Brigham and Women’s Hospital, Boston, Massachusetts

Marc S. Sabatine, MD, MPH
Chairman, TIMI Study Group, Brigham and Women’s Hospital, Associate Professor of Medicine, Harvard Medical School, Boston, Massachusetts
Table of Contents
Cover image
Title page
Look for these other titles in the Braunwald Heart Disease family
Copyright
Dedication
Contributors
Foreword
Preface
Acknowledgments
Part I: Decision Making and Therapeutic Strategies in Cardiovascular Medicine
Chapter 1: Tools for Assessment of Cardiovascular Tests and Therapies
Interpretation of Diagnostic Tests
Clinical Trials
How to Read and Interpret a Clinical Trial
Meta-Analysis
Comparative Effectiveness Research
Cost-Effectiveness Analysis
Chapter 2: New Drug Development
Overview of the Drug Development Process
International Drug Development Overview
Anatomy of a Clinical Trial: Operations
Economics of New Drug Development
Summary
Chapter 3: Device Development for Cardiovascular Therapeutics: Concepts and Regulatory Implications
Overview
Medical Device Development and Differences from Drugs
Regulatory Fundamentals
Contemporary Regulatory Issues
Risk, Benefit, and the Product Life Cycle
Ensuring the Safety of Marketed Devices
Other Key Regulatory Topics
Chapter 4: Pharmacogenetics
Clopidogrel
Warfarin
Statins
Chapter 5: Systems of Health Care
Systems Theory
Why Systems of Care Are Needed
Experience to Date with Cardiovascular Systems of Care
Quality Improvement Theory
Experience to Date with Cardiovascular Quality Improvement
Lessons Learned
Chapter 6: Global Cardiovascular Therapy
Introduction to Global Challenges in Cardiovascular Disease Therapy
Burden of Cardiovascular Disease
Current Trends and Challenges
Population Strategies
Summary
Part II: Ischemic Heart Disease
Chapter 7: Pharmacologic Options for Treatment of Ischemic Disease
Organic Nitrates
Calcium Channel Blockers
β-Adrenergic Blockers
Newer Options for Treatment of Chronic Angina
Thrombosis and Ischemic Cardiovascular Heart Disease
Chapter 8: Stable Ischemic Heart Disease/Chronic Stable Angina
Epidemiology
Natural History
Assessment and Investigation
Therapeutic Interventions
Potential Future Therapies
Chapter 9: Non–ST-Segment Elevation Acute Coronary Syndromes
Antiischemic Medications
Antiplatelet Agents
Platelet Function Testing and Genetics
Anticoagulants
Invasive Versus Conservative Strategy for Cardiac Catheterization
Hospital Discharge and Postdischarge Care
Chapter 10: ST-Segment Elevation Myocardial Infarction
Overview
Pre–ST-Segment Elevation Myocardial Infarction Management
Prehospital Management
Emergency Department Management
Early Risk Assessment
Hospital Management
Long-Term Management
Chapter 11: Advances in Coronary Revascularization
Overview
Advances in Coronary Stenting
Advances in Revascularization in Specific Conditions
Advances in Catheterization Techniques
Advances in Surgical Coronary Revascularization
Part III: Heart Failure
Chapter 12: Pharmacologic Management of Heart Failure in the Ambulatory Setting
Pathophysiology and Staging System: Targets of Therapy
Future Directions in Pharmacologic Therapy
Chapter 13: Implantable Devices for the Management of Heart Failure
Implantable Cardioverter-Defibrillators in the Management of Heart Failure
Implantable Cardioverter-Defibrillators Early After Myocardial Infarction
Indications for Prophylactic Cardioverter-Defibrillator Implantation in Heart Failure Patients
Practical Considerations in Implantable Cardioverter-Defibrillator Therapy
Conduction Abnormalities in Heart Failure
Landmark Cardiac Resynchronization Therapy Clinical Trials
Cardiac Resynchronization Therapy in Mild Heart Failure
Cardiac Resynchronization Therapy
Monitoring Heart Failure Through Implantable Devices
Future Directions in Implantable Devices for the Management of Heart Failure
Summary
Chapter 14: Strategies for Management of Acute Decompensated Heart Failure
Terminology
Epidemiology
Pathophysiology
General Management
Fluid Management
Vasoactive Therapy
Adjustment of Oral Medications
Other Management Issues
Special Considerations
Unfulfilled Promises and Future Directions
Chapter 15: Cardiac Transplantation and Circulatory Support Devices
Overview
Patient Selection for Advanced Heart Failure Therapies
Cardiac Transplantation
Mechanical Circulatory Support
Chapter 16: Regenerative Therapy for Heart Failure
Circulating Progenitor Cells and Myocardial Regeneration
Hematopoietic Stem Cell Transdifferentiation
Bone Marrow Cells and Clinical Studies
Endogenous Cardiac Progenitors
Age, Cardiac Disease, and Human Cardiac Stem Cell Function
Chapter 17: Hypertrophic, Restrictive, and Infiltrative Cardiomyopathies
Hypertrophic Cardiomyopathy
Restrictive and Infiltrative Cardiomyopathies
Part IV: Arrhythmias and Conduction Disturbances
Chapter 18: Clinical Pharmacology of Antiarrhythmic Drugs
Classification of Antiarrhythmic Drugs
Drugs
Appendix
Chapter 19: Pharmacologic Management of Supraventricular Tachycardias
Pharmacology of Supraventricular Tachycardias
Evaluation of Therapy
Paroxysmal Supraventricular Tachycardia
Mechanisms of Paroxysmal Supraventricular Tachycardia
Atrial Flutter
Junctional Ectopic Tachycardia
Chapter 20: Atrial Fibrillation
Classification
Decision for Rhythm or Rate Control
Maintenance of Sinus Rhythm
Atrial Fibrillation Following Cardiac Surgery
Conclusions
Chapter 21: Nonpharmacologic Treatment of Tachyarrhythmias
Catheter Ablation for the Treatment of Tachyarrhythmias
Practical Considerations
Catheter Ablation by Specific Arrhythmia Syndrome
Atrial Fibrillation
Atrioventricular Junction Ablation for Ventricular Rate Control
Summary
Chapter 22: Role of Implantable Cardioverter-Defibrillators in Primary and Secondary Prevention of Sudden Cardiac Death
Sudden Cardiac Death
Implantable Cardioverter-Defibrillator Systems and Technology
Chapter 23: Treatment of Ventricular Tachycardia and Cardiac Arrest
Ventricular Tachycardia: Acute Management
Management of Cardiac Arrest
Part V: Dyslipoproteinemias and Atherosclerosis
Chapter 24: Drugs for Elevated Low-Density Lipoprotein Cholesterol
Effects on Lipids and Lipoproteins
Pharmacokinetic Properties
Mechanism of Benefit of Statins
Chapter 25: Therapy to Manage Low High-Density Lipoprotein Cholesterol and Elevated Triglycerides
Rationale for Combination Therapy
Combined Dyslipidemia
Cholesteryl Ester Transfer Protein Inhibition
Conclusion
Chapter 26: Cardiovascular Disease and Lifestyle Modification
Dietary Fats and Blood Lipids
Obesity
Chapter 27: Steps Beyond Diet and Drug Therapy for Severe Hypercholesterolemia
Definition of the Target Population
Description of the Patient Population
Extracorporeal Therapies for the Treatment of Severe Hypercholesterolemia
Low-Density Lipoprotein Apheresis: Failure to Treat Individuals Who May Benefit
Surgical Procedures
Conclusions and Recommendations for Therapy
Part VI: Hypertension
Chapter 28: Initial Evaluation and Approach to the Patient with Hypertension
Overview and Definitions
Evaluation of the Patient
Adherence to Antihypertensive Medications
Lifestyle Modifications: Overview
Conclusion
Chapter 29: Pharmacologic Management of Hypertension
Overview
Principles of Treatment
Selecting Drug Therapy
Overview of Drug Classes
Implementing Drug Therapy
Special Populations
Chapter 30: Endocrine Causes of Hypertension
Pheochromocytoma
Primary Aldosteronism
Other Forms of Mineralocorticoid Excess
Thyroid and Parathyroid Disease
Chapter 31: Resistant Hypertension
Pseudoresistance
Diagnosis
Cardiovascular Risk
Secondary Causes of Hypertension
Interfering Substances
Pharmacologic Treatment
Role of the Hypertension Specialist
Chapter 32: Hypertensive Crisis
Overview
Definitions
Epidemiology and Etiology
Pathophysiology
Management of Hypertensive Emergency
Follow-up and Prognosis
Caveats to Therapy in Hypertensive Emergency Care
Chapter 33: Hypertension in Pregnancy
Overview
Epidemiology and Risk Factors
Pathophysiology
Diagnosis
Treatment
Implications for Later Cardiovascular Disease
Conclusions
Chapter 34: Management of Hypertension in Children and Adolescents
Overview
Definitions of High Blood Pressure in Children
Co

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