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1619 pages
English

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Description

Pediatric Allergy supplies the comprehensive guidance you need to diagnose, manage, and treat virtually any type of allergy seen in children. Drs. Leung, Sampson, Geha, and Szefler present the new full-color second edition, with coverage of the diagnosis and management of anaphylaxis, the immune mechanisms underlying allergic disease, the latest diagnostic tests, and more.

  • Treat the full range of pediatric allergic and immunologic diseases through clinically focused coverage relevant to both allergists and pediatricians.
  • Understand the care and treatment of pediatric patients thanks to clinical pearls discussing the best approaches.
  • Easily refer to appendices that list common food allergies and autoantibodies in autoimmune diseases.
  • Apply the newest diagnostic tests available—for asthma, upper respiratory allergy, and more—and know their benefits and contraindications.
  • Treat the allergy at its source rather than the resulting reactions through an understanding of the immune mechanisms underlying allergic diseases.
  • Get coverage of new research that affects methods of patient treatment and discusses potential reasons for increased allergies in some individuals.
  • Better manage potential anaphylaxis cases through analysis of contributing facts and progression of allergic disease.
  • Effectively control asthma and monitor its progression using the new step-by-step approach.
  • Eliminate difficulty in prescribing antibiotics thanks to coverage of drug allergies and cross-reactivity.

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Informations

Publié par
Date de parution 13 octobre 2010
Nombre de lectures 0
EAN13 9781437737783
Langue English
Poids de l'ouvrage 3 Mo

Informations légales : prix de location à la page 0,0523€. Cette information est donnée uniquement à titre indicatif conformément à la législation en vigueur.

Extrait

Pediatric Allergy
Principles and Practice
Second Edition

Donald Y.M. Leung, MD PhD FAAAAI
Edelstein Family Chair of Pediatric Allergy-Clinical Immunology, National Jewish Health, Professor of Pediatrics, University of Colorado Denver School of Medicine, Denver, CO, USA

Hugh A. Sampson, MD
Kurt Hirschhorn Professor of Pediatrics, Dean for Clinical and Translational Biomedical Sciences, Mount Sinai School of Medicine, New York, NY, USA

Raif Geha, MD
Chief, Division of Immunology, Children’s Hospital, James L. Gamble Professor of Pediatrics, Harvard Medical School, Boston, MA, USA

Stanley J. Szefler, MD
Helen Wohlberg and Herman Lambert Chair in Pharmacokinetics, Head, Pediatric Clinical Pharmacology, Department of Pediatrics, National Jewish Health, Professor of Pediatrics and Pharmacology, University of Colorado Denver School of Medicine, Denver, CO, USA
Saunders
Front Matter
SECOND EDITION

Pediatric Allergy
PRINCIPLES AND PRACTICE
DONALD Y. M. LEUNG, MD PhD FAAAAI
Edelstein Family Chair of Pediatric Allergy-Clinical Immunology
National Jewish Health
Professor of Pediatrics
University of Colorado Denver School of Medicine
Denver, CO, USA
HUGH A. SAMPSON, MD
Kurt Hirschhorn Professor of Pediatrics
Dean for Clinical and Translational Biomedical Sciences
Mount Sinai School of Medicine
New York, NY, USA
RAIF GEHA, MD
Chief, Division of Immunology
Children’s Hospital
James L. Gamble Professor of Pediatrics
Harvard Medical School
Boston, MA, USA
STANLEY J. SZEFLER, MD
Helen Wohlberg and Herman Lambert Chair in Pharmacokinetics
Head, Pediatric Clinical Pharmacology
Department of Pediatrics
National Jewish Health
Professor of Pediatrics and Pharmacology
University of Colorado Denver School of Medicine
Denver, CO, USA
For additional online content visit expertconsult.com

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Development Editor: Joanne Scott
Editorial Assistant: Kirsten Lowson
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Design: Stewart Larking
Illustration Manager: Bruce Hogarth
Illustrator: Robert Britton
Marketing Manager: Helena Mutak/Richard Jones
Copyright

SAUNDERS an imprint of Elsevier Inc.
© 2010, Elsevier Inc. All rights reserved.
First edition 2003
Second edition 2010
No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any information storage and retrieval system, without permission in writing from the publisher. Details on how to seek permission, further information about the Publisher’s permissions policies and our arrangements with organizations such as the Copyright Clearance Center and the Copyright Licensing Agency, can be found at our website: www.elsevier.com/permissions .
This book and the individual contributions contained in it are protected under copyright by the Publisher (other than as may be noted herein).


Notice
Knowledge and best practice in this field are constantly changing. As new research and experience broaden our understanding, changes in research methods, professional practices, or medical treatment may become necessary. Practitioners and researchers must always rely on their own experience and knowledge in evaluating and using any information, methods, compounds, or experiments described herein. In using such information or methods they should be mindful of their own safety and the safety of others, including parties for whom they have a professional responsibility.
With respect to any drug or pharmaceutical products identified, readers are advised to check the most current information provided (i) on procedures featured or (ii) by the manufacturer of each product to be administered, to verify the recommended dose or formula, the method and duration of administration, and contraindications. It is the responsibility of practitioners, relying on their own experience and knowledge of their patients, to make diagnoses, to determine dosages and the best treatment for each individual patient, and to take all appropriate safety precautions.
To the fullest extent of the law, neither the Publisher nor the authors, contributors, or editors, assumes any liability for any injury and/or damage to persons or property as a matter of products liability, negligence or otherwise, or from any use or operation of any methods, products, instructions, or ideas contained in the material herein.
British Library Cataloguing in Publication Data
A catalogue record for this book is available from the British Library
Saunders
Pediatric allergy: principles and practice. – 2nd ed.
1. Allergy in children. 2. Immunologic diseases in children.
I. Leung, Donald Y M, 1949-
618.9’297–dc22
ISBN-13: 9781437702712
Library of Congress Cataloging in Publication Data
A catalog record for this book is available from the Library of Congress
Printed in China
Last digit is the print number: 9 8 7 6 5 4 3 2 1
Preface
These are exciting times for physicians who treat children and investigators interested in mechanisms underlying diseases in the area of pediatric allergy, asthma and clinical immunology. There has been a well-documented rise in prevalence of this group of diseases during the past three decades. Protection against microbial infection and treatment of hypersensitivity reactions to environmental triggers have become primary goals for the practicing pediatrician. As a result, investigators at academic centers and in the pharmaceutical industry have partnered to understand mechanisms underlying these diseases and have developed evidence- and mechanism-based approaches for management and treatment of these illnesses. In addition, the National Institutes of Health through the National Institutes of Allergy and Infectious diseases and the National Heart, Lung and Blood Institute have formed networks and collaborative studies to study allergic/immunologic diseases, such as food allergy and asthma. The need to document and summarize this recent remarkable increase in information justifies this new textbook in the field of pediatric allergy and clinical immunology for practicing physicians and investigators interested in this area.
It is often said, ‘Children are not simply small adults.’ In no other subspecialty is this more true than in pediatric allergy and immunology, where the immune system and allergic responses are developing in different host organs. This early age of onset of disease offers special opportunities for prevention and intervention, which cannot be carried out once disease processes have been established in the older child and adult. Indeed, many diseases that pediatricians see in clinical practice are complex diseases thought to result from a multigene predisposition in combination with exposure to an unknown environmental agent. However, the age at which the host is exposed to a particular environmental agent and the resultant immune response are increasingly being recognized as important factors. Furthermore, determining the appropriate time for intervention will be important in defining a window of opportunity to induce disease remission. For example, endotoxin is a known trigger of established asthma in adults but the ‘hygiene hypothesis’ in children suggests that early exposure to endotoxin prior to the onset of allergies may actually prevent allergic responses and thus account for the low prevalence of allergic disease in children living on farms. New information is available on controlling asthma in early childhood but our current treatment does not alter the natural history of the disease.
Pediatric Allergy: Principles and Practice is aimed at updating the reader on the pathophysiology of allergic responses and the atopic triad (asthma, allergic rhinitis, and atopic dermatitis), the mechanisms underlying specific allergic and immunologic diseases, and their socioeconomic impact and new treatment approaches that take advantage of emerging concepts of the pathobiology of these diseases. An outstanding group of authors who are acknowledged leaders in their fields has been assembled because of their personal knowledge, expertise, and involvement with their subject matter in children. Every effort has been made to achieve prompt publication of this book, thus ensuring that the content of each chapter is ‘state of the art.’
Section A presents general concepts critical to an understanding of the impact and causes of allergic diseases. These include reviews of the epidemiology and natural history of allergic disease, genetics of allergic disease and asthma, biology of inflammatory-effector cells, regulation of IgE synthesis, and the developing immune system and allergy. Section B reviews an approach to the child with recurrent infection and specific immunodeficiency and autoimmune diseases that pediatricians frequently encounter. Section C updates the reader on a number of important and emerging immune-directed therapies including immunoglobulin therapy, bone marrow transplantation, immunizations, gene therapy, and stem cell therapy. Section D examines the diagnosis and treatment of allergic disease. The remainder of the book is devoted to the management and treatment of asthma and a number of specific allergic diseases such as upper airway disease, food allergy, allergic skin and eye diseases, drug allergy, latex allergy, insect hypersensitivity, and anaphylaxis. In each

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